EGFR
EGFR(表皮生长因子受体)
EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.
EGFR 相关产品(264)
- GC13761AZD8931 (Sapitinib)CAS: 848942-61-0纯度: >99.50%
A reversible inhibitor of ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3
- GC10225Dacomitinib (PF299804, PF299)CAS: 1110813-31-4纯度: >98.00%
A pan-ErbB receptor tyrosine kinase inhibitor
- GC10250Mubritinib (TAK 165)CAS: 366017-09-6纯度: >99.50%
Mubritinib (TAK 165)是一种有效的选择性 HER2/ErbB2 抑制剂，其IC 50 为6nM。
- GC10606BMS-599626 HydrochlorideCAS: 873837-23-1纯度: >99.50%
BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种选择性的口服生物可利用的 HER1 和 HER2 抑制剂，IC50 分别为 20 和 30 nM。 BMS-599626 Hydrochloride 对 HER4 (IC50=190 nM) 的效力降低约 8 倍，对 VEGFR2、c-Kit、Lck、MEK 的效力超过 100 倍。 BMS-599626 Hydrochloride 抑制肿瘤细胞增殖，并有可能增加肿瘤对放疗的反应。
- GC11892AEE788 (NVP-AEE788)CAS: 497839-62-0纯度: >98.00%
An inhibitor of EGFR and VEGFR tyrosine kinases
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10087 | BIBX 1382 | 196612-93-8 | >98.00% | |
An EGFR inhibitor | ||||
| GC11015 | PD168393 | 194423-15-9 | >98.50% | |
An irreversible EGFR kinase inhibitor | ||||
| GC12249 | Varlitinib (ARRY334543) | 845272-21-1 | - | |
An inhibitor of EGFR and HER2 | ||||
| GC12837 | Compound 56 | 171745-13-4 | - | |
A potent EGFR inhibitor | ||||
| GC13608 | Lapatinib | 231277-92-2 | >99.50% | |
Lapatinib是一种口服的双重EGFR和HER2酪氨酸激酶抑制剂，对HER2阳性乳腺癌具有显著疗效。Lapatinib对纯化的EGFR和HER2的半数抑制浓度（IC₅₀）值分别为10.2nM和9.8nM。 | ||||
| GC13761 | AZD8931 (Sapitinib) | 848942-61-0 | >99.50% | |
A reversible inhibitor of ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3 | ||||
| GC16308 | AZD-9291 | 1421373-65-0 | >99.50% | |
An inhibitor of mutant EGFR | ||||
| GC16869 | Ixabepilone | 219989-84-1 | >99.50% | |
A broad-spectrum anticancer agent | ||||
| GC17226 | AG-1478 | 153436-53-4 | >99.00% | |
AG-1478是一种选择性的表皮生长因子受体（EGFR）酪氨酸激酶抑制剂，其IC 50 值为3nM。 | ||||
| GC10217 | RG-14620 | 136831-49-7 | >99.50% | |
An inhibitor of EGF receptor kinase | ||||
| GC10225 | Dacomitinib (PF299804, PF299) | 1110813-31-4 | >98.00% | |
A pan-ErbB receptor tyrosine kinase inhibitor | ||||
| GC10250 | Mubritinib (TAK 165) | 366017-09-6 | >99.50% | |
Mubritinib (TAK 165)是一种有效的选择性 HER2/ErbB2 抑制剂，其IC 50 为6nM。 | ||||
| GC10362 | Neratinib (HKI-272) | 698387-09-6 | >99.50% | |
A dual inhibitor of EGFR and HER2 | ||||
| GC10606 | BMS-599626 Hydrochloride | 873837-23-1 | >99.50% | |
BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种选择性的口服生物可利用的 HER1 和 HER2 抑制剂，IC50 分别为 20 和 30 nM。 BMS-599626 Hydrochloride 对 HER4 (IC50=190 nM) 的效力降低约 8 倍，对 VEGFR2、c-Kit、Lck、MEK 的效力超过 100 倍。 BMS-599626 Hydrochloride 抑制肿瘤细胞增殖，并有可能增加肿瘤对放疗的反应。 | ||||
| GC10707 | Afatinib dimaleate | 850140-73-7 | >99.50% | |
An inhibitor of EGFR and ErbB2 | ||||
| GC10815 | BIBU 1361 dihydrochloride | 793726-84-8 | - | |
EGFR inhibitor | ||||
| GC11024 | AG-213 | 122520-86-9 | >98.00% | |
An inhibitor of EGF receptor kinase | ||||
| GC11172 | TAK-285 | 871026-44-7 | >98.00% | |
A dual inhibitor of EGFR and HER2 | ||||
| GC11250 | WZ8040 | 1214265-57-2 | >98.00% | |
An inhibitor of mutant EGFR | ||||
| GC11264 | CNX-2006 | 1375465-09-0 | >99.50% | |
An irreversible inhibitor of mutant EGFRs | ||||
| GC11312 | EGFR Inhibitor | 879127-07-8 | >99.00% | |
A selective antagonist of the EGFR | ||||
| GC11744 | AG 555 | 133550-34-2 | >98.00% | |
A tyrphostin EGFR inhibitor | ||||
| GC11845 | AG-82 | 118409-58-8 | - | |
An inhibitor of EGF receptor kinase | ||||
| GC11892 | AEE788 (NVP-AEE788) | 497839-62-0 | >98.00% | |
An inhibitor of EGFR and VEGFR tyrosine kinases | ||||