Tyrosine Kinase
Tyrosine Kinase(酪氨酸激酶)
- Bcr-Abl(73)
- Ack1(3)
- Axl(6)
- ALK(64)
- BMX Kinase(3)
- Broad Spectrum Protein Kinase Inhibitor(10)
- c-FMS(42)
- c-Kit(58)
- c-MET(99)
- c-RET(7)
- CSF-1R(3)
- DDR1/DDR2 Receptor(1)
- EGFR(278)
- EphB4(1)
- FAK(39)
- FGFR(104)
- FLT3(97)
- HER2(15)
- IGF1R(34)
- Insulin Receptor(46)
- IRAK(32)
- ITK(10)
- Lck(1)
- LRRK2(25)
- PDGFR(113)
- PTKs/RTKs(10)
- Pyk2(8)
- ROR(41)
- Spleen Tyrosine Kinase (Syk)(33)
- Src(108)
- Tie-2 (4)
- Trk(43)
- VEGFR(200)
- Kinase
- Discoidin Domain Receptor(16)
- DYRK(35)
- Ephrin Receptor(13)
- RET(30)
- ROS(14)
- TAM Receptor(33)
- IGFBR(1)
- Others(55)
Tyrosine Kinase 相关产品(1402)
- GC34528cFMS Receptor Inhibitor IICAS: 959860-85-6纯度: >99.50%
cFMSReceptorInhibitorII是一种CSF1R激酶抑制剂。CSF-1是一种细胞因子。
- GC34708Pexidartinib hydrochlorideCAS: 2040295-03-0纯度: >99.50%
A multi-targeted receptor tyrosine kinase inhibitor
- GC34710PF-06747711CAS: 1892576-58-7纯度: >99.00%
PF-06747711是一种有效、选择性、可口服的视黄酸受体相关孤儿受体C2(RORC2或RORγt)的反向激动剂，IC50值为4.1nM。具有抗皮肤炎的功效。
- GC34809SPP-86CAS: 1357349-91-7纯度: >99.50%
SPP-86, a potent and selective cell permeable inhibitor of rearranged during transfection (RET) tyrosine kinase with an IC50 of 8 nM, inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
- GC34811SRI 31215 TFACAS: 1832686-44-8纯度: >98.50%
SRI31215(TFA)是一种matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂，IC50值分别为0.69μM、0.65μM、0.3μM，SRI31215通过阻断pro-HGF的活化，从而模拟了HAI-1/2的活性。
- GC350952-Phospho-L-ascorbic acid trisodium saltCAS: 66170-10-3纯度: >97.00% / >99.00%
Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.
- GC35280Alectinib HydrochlorideCAS: 1256589-74-8纯度: >99.50%
Alectinib Hydrochloride是一种强效、选择性、可口服的ALK抑制剂，IC 50 值为1.9nM，K d 值为2.4nM。
- GC35287ALK inhibitor 1CAS: 761436-81-1纯度: >99.50%
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
- GC35413Astragaloside VICAS: 84687-45-6纯度: >99.50%
Astragaloside VI 可通过激活表皮生长因子受体/细胞外信号调节激酶 (EGFR/ERK) 信号通路来加速伤口愈合。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC34528 | cFMS Receptor Inhibitor II | 959860-85-6 | >99.50% | |
cFMSReceptorInhibitorII是一种CSF1R激酶抑制剂。CSF-1是一种细胞因子。 | ||||
| GC34529 | c-Fms-IN-1 | 885703-64-0 | >99.50% | |
c-Fms-IN-1是一种FMS激酶抑制剂，IC50值为0.0008μM。 | ||||
| GC34708 | Pexidartinib hydrochloride | 2040295-03-0 | >99.50% | |
A multi-targeted receptor tyrosine kinase inhibitor | ||||
| GC34710 | PF-06747711 | 1892576-58-7 | >99.00% | |
PF-06747711是一种有效、选择性、可口服的视黄酸受体相关孤儿受体C2(RORC2或RORγt)的反向激动剂，IC50值为4.1nM。具有抗皮肤炎的功效。 | ||||
| GC34809 | SPP-86 | 1357349-91-7 | >99.50% | |
SPP-86, a potent and selective cell permeable inhibitor of rearranged during transfection (RET) tyrosine kinase with an IC50 of 8 nM, inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. | ||||
| GC34811 | SRI 31215 TFA | 1832686-44-8 | >98.50% | |
SRI31215(TFA)是一种matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂，IC50值分别为0.69μM、0.65μM、0.3μM，SRI31215通过阻断pro-HGF的活化，从而模拟了HAI-1/2的活性。 | ||||
| GC34847 | TX1-85-1 | 1603845-32-4 | >98.00% | |
An ErbB3 inhibitor | ||||
| GC35053 | 123C4 | 2034159-30-1 | - | |
123C4 是一种有效、选择性的，竞争性受体酪氨酸激酶 EPHA4 激动剂，Ki 值为 0.65 μM. | ||||
| GC35095 | 2-Phospho-L-ascorbic acid trisodium salt | 66170-10-3 | >97.00% / >99.00% | |
Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. | ||||
| GC35209 | A 419259 | 364042-47-7 | - | |
An inhibitor of Src family kinases | ||||
| GC35213 | A-770041 | 869748-10-7 | >99.00% | |
A LCK kinase inhibitor | ||||
| GC35214 | A-9758 | 2055271-22-0 | - | |
A-9758 是一种 RORγ 配体和一种有效选择性的 RORγt 反向激动剂 (IC50 值为 5 nM)，并且强效抑制 IL-17A 释放。A-9758 有效抑制 Th17 分化和 Th17 效应子功能。A-9758 显着减弱 IL-23 驱动型银屑病性皮炎，并有效阻断皮肤和关节炎症。 | ||||
| GC35225 | AC710 Mesylate | 1351522-05-8 | - | |
A PDGFR family kinase inhibitor | ||||
| GC35263 | AG-13958 | 319460-94-1 | >99.50% | |
AG-13958 (AG-013958), a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD). | ||||
| GC35280 | Alectinib Hydrochloride | 1256589-74-8 | >99.50% | |
Alectinib Hydrochloride是一种强效、选择性、可口服的ALK抑制剂，IC 50 值为1.9nM，K d 值为2.4nM。 | ||||
| GC35287 | ALK inhibitor 1 | 761436-81-1 | >99.50% | |
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). | ||||
| GC35289 | ALK-IN-5 | 2351929-66-1 | - | |
ALK-IN-5 是一种高效选择性的，可渗透大脑屏障的 (ALK) 激酶抑制剂，IC50 值为 2.9 nM。 | ||||
| GC35290 | ALK-IN-6 | 2055821-33-3 | - | |
ALK-IN-6 (compound 11) 是口服有效的，间变性淋巴瘤激酶 (ALK) 的抑制剂，其对野生型 ALK、ALK F1196M 和ALK F1174L 的 IC50 值分别为 71 nM、18.72 nM 和36.81 nM。 | ||||
| GC35315 | AMG 925 HCl | 1401034-19-2 | >98.00% | |
A dual inhibitor of FLT3 and Cdk4 | ||||
| GC35413 | Astragaloside VI | 84687-45-6 | >99.50% | |
Astragaloside VI 可通过激活表皮生长因子受体/细胞外信号调节激酶 (EGFR/ERK) 信号通路来加速伤口愈合。 | ||||
| GC35435 | AV-412 | 451493-31-5 | >98.00% | |
A dual inhibitor of EGFR and HER2 | ||||
| GC35436 | AV-412 free base | 451492-95-8 | >98.00% | |
A dual inhibitor of EGFR and HER2 | ||||
| GC35462 | Bafetinib | 859212-16-1 | >99.50% | |
A Bcr-Abl inhibitor | ||||
| GC35516 | BIBF 1202 | 894783-71-2 | >99.00% | |
An active metabolite of BIBF 1120 | ||||