GlpBio

BIBF 1202

目录号: GC35516纯度: >99.00%
An active metabolite of BIBF 1120
BIBF 1202
Cas No.: 894783-71-2
规格价格库存数量操作
1mg¥296.00现货
1
5mg¥1,170.00现货
1
10mg询价现货
1
50mg询价现货
1
10mM (in 1mL DMSO)¥1,353.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

BIBF 1202 is an active metabolite of the VEGFR, FGFR, and PDGFR inhibitor BIBF 1120 .1,2 It is formed from BIBF 1120 by intracellular esterases.1 BIBF 1202 inhibits VEGFR2 with an IC50 value of 62 nM.

1.Hilberg, F., Roth, G.J., Krssak, M., et al.BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyCancer Res.68(12)4774-4782(2008) 2.Lin, D., Qiao, L.M., Zhang, Y.N., et al.Simultaneous determination of nintedanib and its metabolite by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.117173-177(2016)

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
894783-71-2
SMILES
O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)O
分子式
C30H31N5O4
分子量
525.6 g/mol
溶解性
DMSO: ≥ 45 mg/mL (85.62 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol