Tyrosine Kinase
Tyrosine Kinase(酪氨酸激酶)
- Bcr-Abl(73)
- Ack1(3)
- Axl(6)
- ALK(64)
- BMX Kinase(3)
- Broad Spectrum Protein Kinase Inhibitor(10)
- c-FMS(42)
- c-Kit(58)
- c-MET(99)
- c-RET(7)
- CSF-1R(3)
- DDR1/DDR2 Receptor(1)
- EGFR(278)
- EphB4(1)
- FAK(39)
- FGFR(104)
- FLT3(97)
- HER2(15)
- IGF1R(34)
- Insulin Receptor(46)
- IRAK(32)
- ITK(10)
- Lck(1)
- LRRK2(25)
- PDGFR(113)
- PTKs/RTKs(10)
- Pyk2(8)
- ROR(41)
- Spleen Tyrosine Kinase (Syk)(33)
- Src(108)
- Tie-2 (4)
- Trk(43)
- VEGFR(200)
- Kinase
- Discoidin Domain Receptor(16)
- DYRK(35)
- Ephrin Receptor(13)
- RET(30)
- ROS(14)
- TAM Receptor(33)
- IGFBR(1)
- Others(55)
Tyrosine Kinase 相关产品(1402)
- GC33141SKLB4771 (FLT3-IN-1)CAS: 1370256-78-2纯度: >98.00%
SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10?nM.
- GC33172BGB-102 (JNJ-26483327)CAS: 807640-87-5
BGB-102 (JNJ-26483327) 是一种有效的多激酶抑制剂，针对 EGFR、HER2 和 HER4，IC50 分别为 9.6 nM、18 nM 和 40.3 nM。
- GC33181T338C Src-IN-2CAS: 1351927-00-8
T338CSrc-IN-2是突变型c-Src激酶抑制剂，IC50值317nM，还能抑制T338C/V323A和T338C/V323S双突变Src活性，IC50值57和19nM。
- GC33189SAR125844CAS: 1116743-46-4纯度: >98.00%
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
- GC33241CSF1R-IN-1CAS: 2095849-04-8纯度: >98.50%
CSF1R-IN-1 is a CSF1R (Colony Stimulating Factor 1 Receptor) inhibitor with an IC50 of 0.5 nM in vitro kinase activity assay.
- GC33266JNJ-38877618CAS: 943540-74-7纯度: >98.00%
JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).
- GC33273TAS-115 mesylate (TAS-115 methanesulfonate)CAS: 1688673-09-7纯度: >99.00%
A multi-kinase inhibitor
- GC333192-Keto Crizotinib (PF-06260182)CAS: 1415558-82-5
2-Keto Crizotinib (PF-06260182) (PF-06260182) 是 crizotinib 的活性内酰胺代谢物。
- GC33361DDR InhibitorCAS: 1644069-80-6纯度: >99.00%
DDRInhibitor是一种高效的盘状结构域受体(discoidindomainreceptor)抑制剂，对DDR2的IC50值为3.3nM，在浓度为1.5nM时，对DDR1有53%的抑制作用。
- GC33362Amuvatinib hydrochloride (MP470 hydrochloride)CAS: 1055986-67-8
A multi-targeted RTK inhibitor
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC33141 | SKLB4771 (FLT3-IN-1) | 1370256-78-2 | >98.00% | |
SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10?nM. | ||||
| GC33168 | T338C Src-IN-1 | 1351926-90-3 | - | |
T338CSrc-IN-1是突变型c-SrcT338C高效抑制剂，IC50值111nM。对WTSrc活性弱10倍以上。 | ||||
| GC33171 | ZD-4190 | 413599-62-9 | >99.00% | |
ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively. | ||||
| GC33172 | BGB-102 (JNJ-26483327) | 807640-87-5 | - | |
BGB-102 (JNJ-26483327) 是一种有效的多激酶抑制剂，针对 EGFR、HER2 和 HER4，IC50 分别为 9.6 nM、18 nM 和 40.3 nM。 | ||||
| GC33173 | TAS-115 | 1190836-34-0 | - | |
A multi-kinase inhibitor | ||||
| GC33181 | T338C Src-IN-2 | 1351927-00-8 | - | |
T338CSrc-IN-2是突变型c-Src激酶抑制剂，IC50值317nM，还能抑制T338C/V323A和T338C/V323S双突变Src活性，IC50值57和19nM。 | ||||
| GC33189 | SAR125844 | 1116743-46-4 | >98.00% | |
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively). | ||||
| GC33190 | Ensartinib (X-396) | 1370651-20-9 | - | |
An ALK inhibitor | ||||
| GC33195 | EGFR-IN-2 | 1643497-70-4 | - | |
EGFR-IN-2是一种非共价的，不可逆的，突变选择性的二代EGFR抑制剂。 | ||||
| GC33201 | GZD856 | 1257628-64-0 | - | |
GZD856是一种新型，有口服活性的PDGFRα/β抑制剂，IC50分别为68.6和136.6nM。具有抗肺癌活性。也是Bcr-AblT315I的抑制剂，对Bcr-Abl和T315I突变型的IC50分别为19.9和15.4 nM。 | ||||
| GC33203 | c-Met-IN-2 | 1635406-73-3 | - | |
c-Met-IN-2是一种有效的，选择性的，可口服的c-Met抑制剂，IC50值为0.6nM，具有抗肿瘤活性。 | ||||
| GC33241 | CSF1R-IN-1 | 2095849-04-8 | >98.50% | |
CSF1R-IN-1 is a CSF1R (Colony Stimulating Factor 1 Receptor) inhibitor with an IC50 of 0.5 nM in vitro kinase activity assay. | ||||
| GC33242 | FLT3-IN-1 Succinate | 1702864-11-6 | - | |
FLT3-IN-1Succinate是有效地FLT3抑制剂，来自专利WO2015056683A1，化合物实例A。 | ||||
| GC33246 | AZD3229 Tosylate | 2248003-71-4 | >98.50% | |
An inhibitor of c-Kit-driven cell proliferation | ||||
| GC33266 | JNJ-38877618 | 943540-74-7 | >98.00% | |
JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50). | ||||
| GC33271 | R916562 | 1037798-41-6 | - | |
R916562是有效的和有选择性的Axl/VEGF-R2双重抑制剂,IC50值分别为136和24nM。 | ||||
| GC33273 | TAS-115 mesylate (TAS-115 methanesulfonate) | 1688673-09-7 | >99.00% | |
A multi-kinase inhibitor | ||||
| GC33297 | DDR1-IN-3 | 1934246-19-1 | - | |
DDR1-IN-3 是一种选择性 Discoidin Domain Receptor 1 (DDR1) 抑制剂，IC50 值为 9.4 nM。 DDR1-IN-3 也抑制 TRK 家族。 | ||||
| GC33319 | 2-Keto Crizotinib (PF-06260182) | 1415558-82-5 | - | |
2-Keto Crizotinib (PF-06260182) (PF-06260182) 是 crizotinib 的活性内酰胺代谢物。 | ||||
| GC33343 | BCR-ABL-IN-1 | 188260-50-6 | - | |
BCR-ABL-IN-1是一种BCR-ABL酪氨酸激酶抑制剂，pIC50值为6.46，可能用于慢性髓细胞白血病的研究。 | ||||
| GC33351 | CZC-8004 (CZC-00008004) | 916603-07-1 | >99.50% | |
A tyrosine kinase inhibitor | ||||
| GC33352 | CP-547632 | 252003-65-9 | >98.50% | |
A potent inhibitor of VEGFR2 and bFGF | ||||
| GC33361 | DDR Inhibitor | 1644069-80-6 | >99.00% | |
DDRInhibitor是一种高效的盘状结构域受体(discoidindomainreceptor)抑制剂，对DDR2的IC50值为3.3nM，在浓度为1.5nM时，对DDR1有53%的抑制作用。 | ||||
| GC33362 | Amuvatinib hydrochloride (MP470 hydrochloride) | 1055986-67-8 | - | |
A multi-targeted RTK inhibitor | ||||