CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.1 It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.1
1.Klutchko, S.R., Hamby, J.M., Boschelli, D.H., et al.2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activityJ. Med. Chem.41(17)3276-3292(1998)