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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

Cat.No. 产品名称 Information
GC12370 IKK-16 (hydrochloride)
IKK Inhibitor VII
IKK-16 (hydrochloride)是一种新型的、具有口服活性的选择性IκB激酶（IKK）抑制剂，IKK-16作用于IKK-2、IKK复合物和IKK-1的IC₅₀值分别为40nM、70nM和200nM
GC17925 PKR-IN-C16
C16,GW 506033X,Protein Kinase RNA-activated
PKR-IN-C16是一种靶向ATP结合位点的小分子化合物，能够抑制RNA依赖性蛋白激酶（PKR）的自磷酸化，IC₅₀值为0.21±0.04μM。
GC14054 SR 0987 An agonist of RORγt
GC10408 2-D08 2-D08是一种合成黄酮和具有细胞通透性的小泛素样修饰蛋白（SUMO）抑制剂，也能抑制Axl靶点，IC₅₀为0.49nM。
GC12818 4-methyl Erlotinib
埃罗替尼杂质G
A methylated analog of erlotinib
GC10706 Rp-8-pCPT-Cyclic GMPS (sodium salt)
Rp-8-pCPT-cGMPS
A competitive inhibitor of cGK isoforms
GC10517 Rp-8-bromo-Cyclic GMPS (sodium salt)
Rp-8-bromo-cGMPS
A competitive inhibitor of cGK
GC15145 CEP-28122 An orally active ALK inhibitor
GC15314 PD 166326 An inhibitor of c-src and certain receptor tyrosine kinases, including c-abl
GC10938 AAL-993
VEGFR Tyrosine Kinase Inhibitor VI,ZK 260253
Inhibitor of VEGFR1, 2, and 3
GC13905 GSK2981278 An inverse agonist of RORγ
GC14544 JNJ-10198409
3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基)苯基胺
A potent PDGF tyrosine kinase inhibitor
GC10644 Neoruscogenin
新鲁斯可皂苷元
A bioavailable agonist of RORα
GC14418 SR 1555 (hydrochloride) inverse agonist of RORγ
GC15280 Tivozanib (hydrate)
AV-951,KRN 951
A VEGFR inhibitor
GC16483 MAZ51 MAZ51是一种选择性血管内皮生长因子受体3（VEGFR-3；FLT4）酪氨酸激酶抑制剂。
GC11312 EGFR Inhibitor
Epidermal Growth Factor Receptor Inhibitor
A selective antagonist of the EGFR
GC14856 EGFR/ErbB2 Inhibitor A dual inhibitor of EGFR and ErbB2
GC13961 ISCK03
STEM-CELLFACTOR/C-KIT抑制剂 ,c-Kit Inhibitor II,Stem-Cell Factor/c-Kit Inhibitor
An inhibitor of SCF/c-kit signaling
GC14103 NSC228155 An EGFR activator and inhibitor of KID-KIX interactions
GC15370 Olmutinib (HM61713, BI 1482694)
奥莫替尼
An inhibitor of mutant EGFR
GC12712 NT157 NT157是一种具有选择性的胰岛素受体底物-1/-2（IRS-1/2）抑制剂。
GC11726 BAW2881 (NVP-BAW2881)
BAW2881
A VEGFR inhibitor
GC15340 BFH772 An inhibitor of VEGFR2
GC15655 AMG 337 A selective c-Met inhibitor
GC15282 LOXO-101 (Larotrectinib) sulfate
(3S)-N-[5-[(2R)-2-(2,5-二氟苯基)-1-吡咯烷基]吡唑并[1,5-A]嘧啶-3-基]-3-羟基-1-吡咯烷甲酰胺硫酸盐,LOXO-101 sulfate; ARRY-470 sulfate
LOXO-101 (Larotrectinib) sulfate是一种口服可用的ATP竞争性泛TRK抑制剂，对TRKA和TRKC的IC₅₀值分别为0.9nM和2.8nM。
GC11321 PRT-060318
PRT318
A potent and selective Syk inhibitor
GC15466 RO9021 RO9021 是一种具有口服生物利用度的新型 ATP 竞争性 SYK 抑制剂，平均 IC50 为 5.6 nM。
GC12038 RG 13022
Tyrphostin RG13022
An inhibitor of EGF receptor kinase
GC14582 SU5614
(3Z)-5-氯-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-1,3-二氢-2H-吲哚-2-酮
A multi-kinase inhibitor
GC12281 EAI045 A potent inhibitor of mutant EGFRs
GC10607 GNF-7 A multi-kinase inhibitor
GC17294 CHMFL-ABL-053 CHMFL-ABL-053 (Compound 18a) 是一种有效的、选择性的、可口服的 BCR-ABL、SRC 和 p38 激酶抑制剂，对 ABL1、SRC 和 p38 的 IC50 值分别为 70、90 和 62 nM。
GC14488 NPS-1034
2-(4-氟苯基)-N-[3-氟-4-[(3-苯基-1H-吡咯并[2,3-B]吡啶-4-基)氧基]苯基]-2,3-二氢-1,5-二甲基-3-氧代-1H-吡唑-4-甲酰胺
A dual MET/AXL inhibitor
GC13143 AZD3759
AZD3759
A brain penetrant inhibitor of EGFR
GC10165 Dovitinib (TKI258) Lactate Hydrate
多韦替尼,TKI258 lactate hydrate; CHIR-258 lactate hydrate

A multi-kinase inhibitor
GC14218 TP-0903
TP-0903
An Axl kinase inhibitor
GC17790 CL-387785 (EKI-785)
EKI-785; WAY-EKI 785
An irreversible inhibitor of EGFR kinase activity
GC16321 EGF816
那扎替尼; EGF816
An inhibitor of mutant EGFR
GC10355 Fruquintinib(HMPL-013)
呋喹替尼; HMPL-013
An inhibitor of VEGF1, -2, and -3
GC17772 BMS-817378
[3-[[4-((2-氨基-3-氯吡啶-4-基)氧基)-3-氟苯基]氨基甲酰基]-5-(4-氟苯基)-4-氧代-4H-吡啶-1-基]甲基磷酸二氢酯
Potent ATP competitive inhibitor of Met/VEGFR2
GC14476 Entrectinib
恩曲替尼; NMS-E628; RXDX-101
Entrectinib是一种具有口服活性、可穿透血脑屏障（BBB）且在中枢神经系统起作用的TrkA/B/C、ROS1与ALK抑制剂，其IC₅₀值分别为1、3、5、12和7nM。
GC12222 Pexidartinib (PLX3397)
培西达替尼,PLX-3397
Pexidartinib(PLX3397) 是一种口服小分子酪氨酸激酶抑制剂，对集落刺激因子 1(CSF1) 受体 (IC50=20nM)、KIT 原癌基因受体酪氨酸激酶 (KIT)(IC50 = 10nM) 和类 FMS 酪氨酸激酶 3Pexidartinib 在体外是一种比伊马替尼更强的 KIT 抑制剂。
GC11140 Radotinib(IY-5511)
拉多替尼
A selective Bcr-Abl tyrosine kinase inhibitor
GC17637 CTX0294885 A broad spectrum kinase inhibitor used in proteomics
GC17669 AMG-47A
4-甲基-3-[2-[[2-(4-吗啉基)乙基]氨基]-6-喹唑啉基]-N-[3-(三氟甲基)苯基]苯甲酰胺
A multi-kinase inhibitor
GC17500 SU6656 SU6656是一种小分子吲哚酮类化合物，可选择性抑制Src、Yes和Fyn激酶活性，IC₅₀值分别为0.28μM、0.02μM和0.17μM。
GC12955 AZ5104
奥西替尼中间体
An active metabolite of AZD 9291
GC17959 AZD2932 A multi-kinase inhibitor
GC16604 Altiratinib
DCC-2701
A multiple kinase inhibitor