GlpBio

Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

研究方向

Tyrosine Kinase 相关产品(1402)

  • GC32625 structure
    GC32625KDR-in-4
    CAS: 408502-06-7

    KDR-in-4 (KDR-in-4) 是一种有效的激酶插入结构域受体 (KDR/VEGFR2) 抑制剂，IC50 为 7 nM。

  • GC32703 structure
    GC32703Asciminib (ABL001)
    CAS: 1492952-76-7
    纯度: >99.50%

    An allosteric inhibitor of Abl1

  • GC32713 structure
    GC32713Cintirorgon (LYC-55716)
    CAS: 2055536-64-4
    纯度: >98.00%

    A ROR? agonist

  • GC32726 structure
    GC32726Tucatinib (Irbinitinib)
    CAS: 937263-43-9
    纯度: >99.00%

    An inhibitor of HER2

  • GC32733 structure
    GC32733Pyrotinib (SHR-1258)
    CAS: 1269662-73-8
    纯度: >99.50%

    Pyrotinib (SHR-1258) (SHR-1258) 是一种有效的选择性 EGFR/HER2 双重抑制剂，IC50 分别为 13 和 38 nM。

  • GC32748 structure
    GC32748CA-4948
    CAS: 1801343-74-7
    纯度: >99.50%

    An IRAK-4 inhibitor

  • GC32752 structure
    GC32752TAS6417
    CAS: 1661854-97-2
    纯度: >98.50%

    TAS6417 (CLN-081, TPC-064) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.

  • GC32760 structure
    GC32760Dovitinib lactate (CHIR-258 lactate)
    CAS: 692737-80-7
    纯度: >99.50%

    Dovitinib lactate (CHIR-258 lactate)是一种高效，具有口服活性和安全药代动力学特性的小分子多激酶抑制剂，作用于FLT3、KIT和FGFR等靶点，IC 50 值分别为1、2和8-9nM。

  • GC32769 structure
    GC32769MRX-2843 (UNC2371)
    CAS: 1429882-07-4
    纯度: >98.00%

    A Mer and FLT3 inhibitor

  • GC32797 structure
    GC32797AD80
    CAS: 1384071-99-1
    纯度: >99.50%

    AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

  • GC32802 structure
    GC32802PRN1371
    CAS: 1802929-43-6
    纯度: >99.50%

    An irreversible pan-FGFR inhibitor

  • GC32805 structure
    GC32805Sulfatinib (HMPL-012)
    CAS: 1308672-74-3
    纯度: >98.00%

    A multi-kinase inhibitor

  • GC32808 structure
    GC32808Selitrectinib (LOXO-195)
    CAS: 2097002-61-2
    纯度: >99.00%

    A Trk kinase inhibitor

  • GC32819 structure
    GC32819Mirk-IN-1 (Dyrk1B/A-IN-1)
    CAS: 1386979-55-0
    纯度: >99.50%

    Mirk-IN-1 (Dyrk1B/A-IN-1) 是一种有效的 Dyrk1B(Mirk kianse) 和 Dyrk1A 抑制剂，IC50 分别为 68±48 nM 和 22±8 nM。

  • GC32825 structure
    GC32825eCF506
    CAS: 1914078-41-3
    纯度: >99.00%

    An inhibitor of Src kinases

  • GC32835 structure
    GC32835PP58
    CAS: 212391-58-7
    纯度: >99.00%

    PP58是吡啶[2,3-d]嘧啶化合物，抑制PDGFR，FGFR和Src家族活性的IC50值在纳摩尔级。

  • GC32836 structure
    GC32836Naquotinib mesylate (ASP8273)
    CAS: 1448237-05-5
    纯度: >98.00%

    An irreversible inhibitor of mutant EGFRs

  • GC32864 structure
    GC32864Ensartinib hydrochloride (X-396 hydrochloride)
    CAS: 2137030-98-7
    纯度: >99.00%

    An ALK inhibitor

  • GC32867 structure
    GC32867Flumatinib (HHGV678)
    CAS: 895519-90-1
    纯度: >98.00%

    A Bcr-Abl inhibitor

  • GC32875 structure
    GC32875AZM475271 (M475271)
    CAS: 476159-98-5
    纯度: >99.50%

    An inhibitor of c-Src kinase

  • GC32915 structure
    GC32915Pemigatinib
    CAS: 1513857-77-6
    纯度: >98.00%

    An FGFR inhibitor

  • GC32927 structure
    GC32927PF-06459988
    CAS: 1428774-45-1
    纯度: >99.00%

    PF-06459988是T790M-ContainingEGFRMutants不可逆性抑制剂。

  • GC32963 structure
    GC32963hVEGF-IN-1
    CAS: 1637443-98-1
    纯度: >98.50%

    hVEGF-IN-1是一种喹唑啉衍生物（IRES-A：K d = 0.928μM)。

  • GC32968 structure
    GC32968FLT3-IN-1
    CAS: 1472797-69-5

    FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.