Tyrosine Kinase

Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

4,4'-Bis(4-aminophenoxy)biphenyl is a monomer for polyimide production.

CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumor with EGFR-Del19/T790M/C797S.

CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.

Ehp-inhibitor-1 (Ehp inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors.

Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.

S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.

SU5208(3-[(Thien-2-yl)methylene]-2-indolinone) is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2).

TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay

WAY-340935 (VEGFR2-IN-2) can inhibit the function of VEGFR2 and the anti-proliferative activity against the H460 cell line is produced partly by interaction of VEGFR protein.

Acrizanib是一种具有口服活性的血管内皮生长因子受体2（VEGFR-2）抑制剂。

GENZ-882706(Raceme) (GENZ-882706 外消旋体) 是 GENZ-882706 的外消旋体。

PRN694是一种高度选择且有效的T细胞激酶(ITK)和静息淋巴细胞激酶(RLK)的共价抑制剂，其IC50值分别为0.3和1.4nM。

A unique regulator of PPARγ expression

硫酸乙酰肝素 (HS) 是一种复杂的聚阴离子多糖，广泛表达于细胞表面和细胞外基质。

Dihexa (PNB-0408)（N-己酸-Tyr-Ile-(6)-氨基己酰胺）是一种具有口服活性、可透过血脑屏障的血管紧张素 IV 类似物。

MLi-2是一种高效、选择性的富含亮氨酸重复激酶2（LRRK2）抑制剂，其IC₅₀值为0.76nM，MLi-2具有良好的中枢神经系统穿透能力，是研究LRRK2功能和帕金森病（PD）病理机制的重要工具化合物。

An activator of TrkB and TrkC

TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay.

胰岛素是一种由21个和30个氨基酸组成的激素蛋白质。

An inhibitor of IGF-1R