Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC703683-Methoxy-4-hydroxyphenylglycolCAS: 534-82-7纯度: >97.00%
3-Methoxy-4-hydroxyphenylglycol（HMPG）是大脑中去甲肾上腺素降解的代谢产物。
- GC70404GB111-NH2 hydrochlorideCAS: 956479-18-8纯度: >98.00%
GB111-NH2 hydrochloride是一种半胱氨酸组织蛋白酶抑制剂，可用于癌症研究。
- GC70448MLS000545091CAS: 322666-76-2纯度: >99.00%
MLS000545091是一种有效的选择性脂氧合酶-2（LOX-2）抑制剂，对h15-LOX-2的IC50值为2.6μM。
- GC70524Lignoceric acid (12,12,13,13-d4)CAS: 1219794-59-8纯度: >98.00%
Lignoceric acid (12,12,13,13-d4)是氘标记的木质酸。
- GC70545Fotagliptin benzoateCAS: 1403496-40-1纯度: >99.00%
Fotagliptin benzoate是二肽基肽酶IV（DPP-4）抑制剂（IC50=2.27nM）。
- GC705574β-Hydroxycholesterol-d4CAS: 1363529-44-5纯度: >99.00%
4β-Hydroxycholesterol-d4是氘标记的4β-羟基胆固醇。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC70355 | Thiamine pyrophosphate-d3 | 2483831-79-2 | 不显示 | |
Thiamine pyrophosphate-d3是氘标记的焦磷酸硫胺素。 | ||||
| GC70357 | Indolelactic acid-d5 | 2470130-19-7 | >98.00% | |
Indolelactic acid-d5是氘标记的吲哚乳酸。 | ||||
| GC70361 | 2-Methoxyestrone-d4 | 949885-90-9 | >98.00% | |
2-Methoxyestrone-d4是氘标记的2-甲氧基雌酮。 | ||||
| GC70364 | Aldosterone-d7 | - | >98.00% | |
Aldosterone-d7是氘标记的醛固酮。 | ||||
| GC70365 | L-Xylulose | 527-50-4 | 不显示 | |
L-Xylulose是一种存在于血液、脑脊液和尿液中的内源性代谢产物，可用于核糖5-磷酸异构酶缺乏症的研究。 | ||||
| GC70366 | Coproporphyrin I | 531-14-6 | 不显示 | |
Coproporphyrin I是一种存在于尿液和血液中的内源性代谢产物，可用于肝病和卟啉症的研究。 | ||||
| GC70367 | Etiocholanolone-d5 | 1620102-33-1 | >99.00% | |
Etiocholanolone-d5是氘标记的Etiocholanolone。 | ||||
| GC70368 | 3-Methoxy-4-hydroxyphenylglycol | 534-82-7 | >97.00% | |
3-Methoxy-4-hydroxyphenylglycol（HMPG）是大脑中去甲肾上腺素降解的代谢产物。 | ||||
| GC70369 | Aminoadipic acid-d3 | 2483832-01-3 | 不显示 | |
Aminoadipic acid-d3是氘标记的氨基己二酸。 | ||||
| GC70371 | Anserine-d4 | 1201658-81-2 | 不显示 | |
Anserine-d4是氘标记的安瑟琳。 | ||||
| GC70372 | Suberylglycine-d4 | 2469259-73-0 | >99.00% | |
Suberylglycine-d4是氘标记的亚丙基甘氨酸。 | ||||
| GC70373 | 2-Methylcitric acid-d3 | 146764-58-1 | >98.00% | |
2-Methylcitric acid-d3是氘标记的2-甲基柠檬酸。 | ||||
| GC70374 | Deoxycorticosterone-d8 | 55487-63-3 | >97.00% | |
Deoxycorticosterone-d8是氘标记的脱氧皮质酮。 | ||||
| GC70400 | Mebendazole-amine | 52329-60-9 | 不显示 | |
Mebendazole-amine是甲苯达唑的代谢物。 | ||||
| GC70404 | GB111-NH2 hydrochloride | 956479-18-8 | >98.00% | |
GB111-NH2 hydrochloride是一种半胱氨酸组织蛋白酶抑制剂，可用于癌症研究。 | ||||
| GC70436 | Propaquizafop | 111479-05-1 | >98.00% | |
Propaquizafop是一种苯氧异丙酸除草剂和乙酰辅酶a羧化酶抑制剂。 | ||||
| GC70448 | MLS000545091 | 322666-76-2 | >99.00% | |
MLS000545091是一种有效的选择性脂氧合酶-2（LOX-2）抑制剂，对h15-LOX-2的IC50值为2.6μM。 | ||||
| GC70482 | WNK-IN-1 | 2125724-72-1 | >98.00% | |
WNK-IN-1（化合物7）是一种ATP非竞争性无赖氨酸（WNK）激酶抑制剂（IC50=95 nM）。 | ||||
| GC70518 | α-D-Galactose | 3646-73-9 | >98.00% | |
α-D-Galactose是从百合鳞茎组织中分离得到的一种非淀粉多糖。 | ||||
| GC70524 | Lignoceric acid (12,12,13,13-d4) | 1219794-59-8 | >98.00% | |
Lignoceric acid (12,12,13,13-d4)是氘标记的木质酸。 | ||||
| GC70534 | PPACK TFA | 157379-44-7 | >99.00% | |
PPACK TFA是一种纤溶酶原激活剂(rt-PA)抑制剂。 | ||||
| GC70545 | Fotagliptin benzoate | 1403496-40-1 | >99.00% | |
Fotagliptin benzoate是二肽基肽酶IV（DPP-4）抑制剂（IC50=2.27nM）。 | ||||
| GC70557 | 4β-Hydroxycholesterol-d4 | 1363529-44-5 | >99.00% | |
4β-Hydroxycholesterol-d4是氘标记的4β-羟基胆固醇。 | ||||
| GC70560 | 2-Hydroxyestradiol-d5 | 221093-33-0 | 不显示 | |
2-Hydroxyestradiol-d5是氘标记的2-羟基雌二醇。 | ||||