GlpBio

Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

研究方向

Tyrosine Kinase 相关产品(1402)

  • GC52104 structure
    GC52104Ponatinib (hydrochloride)
    CAS: 1114544-31-8
    纯度: >98.00%

    Ponatinib (hydrochloride)是一种多靶点酪氨酸激酶抑制剂，可抑制Abl（IC 50 =0.37nM），PDGFRα（IC 50 =1.1nM），VEGFR2（IC 50 =1.5nM），FGFR1（IC 50 =2.2nM）和Src（IC 50 =5.4nM）的活性。

  • GC52472 structure
    GC52472Inostamycin A (sodium salt)
    纯度: >85.00%

    A bacterial metabolite with anticancer activity

  • GC52516 structure
    GC52516Erbstatin
    CAS: 100827-28-9
    纯度: >90.00%

    A tyrosine kinase inhibitor

  • GC60154 structure
    GC60154Erlotinib D6
    CAS: 1034651-23-4

    An internal standard for the quantification of erlotinib

  • GC60175 structure
    GC60175GIP (1-30) amide,Human acetate
    纯度: >98.00%

    GIP (1-30) amide,Human acetate 是葡萄糖依赖性促胰岛素多肽 (GIP) 片段。葡萄糖依赖性促胰岛素多肽是一种肠降血糖素激素，可刺激胰岛素分泌并减少餐后血糖波动。GIP (1-30) amide (Human) 在 10-9-10-6 M 范围内剂量依赖性地促进胰岛素分泌。

  • GC60270 structure
    GC60270Nilotinib D6
    CAS: 1268356-17-7

    An internal standard for the quantification of nilotinib

  • GC60283 structure
    GC60283Pentagamavunon-1
    CAS: 27060-70-4
    纯度: >99.50%

    Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。

  • GC60365 structure
    GC60365TIE-2/VEGFR-2 kinase-IN-1
    CAS: 453590-24-4
    纯度: >99.50%

    TIE-2/VEGFR-2 kinase-IN-1 用于合成 TIE-2 或者 VEGFR-2 抑制剂，从专利 WO2003022852 中获得，例 14。TIE-2/VEGFR-2 kinase-IN-1 用于研究不适当的血管生成相关疾病。

  • GC60372 structure
    GC60372TrkA-IN-1
    CAS: 1680179-43-4

    TrkA-IN-1 是一种有效的选择性肌球蛋白相关激酶 A (TrkA) 抑制剂，在基于细胞的测定中，IC50 为 99 nM。TrkA-IN-1 具有镇痛作用。

  • GC60567 structure
    GC60567Afatinib impurity 11
    CAS: 1402086-20-7
    纯度: >99.00%

    Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor.

  • GC60592 structure
    GC60592APS6-45
    CAS: 2188236-41-9
    纯度: >99.50%

    APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.

  • GC60601 structure
    GC60601ARRY-382
    CAS: 1313407-95-2
    纯度: >99.00%

    ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM.

  • GC60629 structure
    GC60629BDTX-189
    CAS: 2414572-47-5
    纯度: >99.50%

    An inhibitor of wild-type and mutant EGFR and HER2

  • GC60726 structure
    GC60726CP-547632 TFA
    纯度: >99.00%

    A potent inhibitor of VEGFR2 and bFGF

  • GC60868 structure
    GC60868Gefitinib D8
    CAS: 857091-32-8
    纯度: >98.00%

    GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。

  • GC60930 structure
    GC60930Imatinib D4
    CAS: 1134803-16-9

    ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。

  • GC61111 structure
    GC61111NBI-31772 hydrate
    纯度: >98.00%

    A nonpeptide ligand that releases IGF-1 from IGFBP

  • GC61161 structure
    GC61161Osimertinib D6
    纯度: >99.50%

    OsimertinibD6(AZD-9291D6)是Osimertinib的一种氘代化合物。Osimertinib是一种不可逆和突变的选择性的EGFR抑制剂，抑制EGFRL858R和EGFRL858R/T790M的IC50分别为12和1nM。

  • GC61217 structure
    GC61217Protein kinase inhibitors 1 hydrochloride
    纯度: >98.00%

    Proteinkinaseinhibitors1hydrochloride是一种有效的HIPK2抑制剂，对HIPK1和HIPK2的IC50值分别为136和74nM，对HIPK2的Kd值为9.5nM。

  • GC61454 structure
    GC61454GW806742X hydrochloride
    纯度: >98.50%

    GW806742Xhydrochloride是一种ATP模拟物，是一种有效的MLKL抑制剂，结合MLKL假激酶结构域，Kd值为9.3μM。GW806742Xhydrochloride具有抗VEGFR2的活性(IC50=2nM)。GW806742Xhydrochloride延缓MLKL膜移位并抑制坏死。

  • GC61473 structure
    GC61473Trastuzumab deruxtecan
    CAS: 1826843-81-5
    纯度: >98.50% / >99.00%

    Trastuzumab deruxtecan（曲妥珠单抗）是一种人表皮生长因子受体2（HER2）靶向抗体-药物偶联物（ADC），由人源化抗人HER2（抗hHER2）抗体、酶促裂解肽接头和拓扑异构酶I抑制剂（DX-8951衍生物）组成。

  • GC61490 structure
    GC61490Trastuzumab emtansine
    CAS: 1018448-65-1
    纯度: >98.00%

    Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.

  • GC61516 structure
    GC61516MID-1
    CAS: 312608-54-1
    纯度: >97.00%

    MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction, which can disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.

  • GC61550 structure
    GC61550S961 acetate
    纯度: >99.50%

    S961acetate是一种高亲和力的胰岛素受体(insulinreceptor,IR)拮抗剂，对HIR-A，HIR-B和人胰岛素样生长因子I受体(HIGF-IR)的IC50分别为0.048，0.027和630nM。