GlpBio

Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

研究方向

Tyrosine Kinase 相关产品(1402)

  • GC12273 structure
    GC12273GSK1838705A
    CAS: 1116235-97-2
    纯度: >99.00%

    GSK1838705A是一种小分子激酶抑制剂，可靶向胰岛素样生长因子1受体（IGF-1R）和胰岛素受体，其IC₅₀分别为2.0nM和1.6nM。

  • GC12281 structure
    GC12281EAI045
    CAS: 1942114-09-1
    纯度: >98.50%

    A potent inhibitor of mutant EGFRs

  • GC12370 structure
    GC12370IKK-16 (hydrochloride)
    CAS: 1186195-62-9

    IKK-16 (hydrochloride)是一种新型的、具有口服活性的选择性IκB激酶（IKK）抑制剂，IKK-16作用于IKK-2、IKK复合物和IKK-1的IC 50 值分别为40nM、70nM和200nM

  • GC12461 structure
    GC12461HA-100 (hydrochloride)
    CAS: 210297-47-5

    An inhibitor of PKA, PKC, and PKG

  • GC12531 structure
    GC12531Cabozantinib malate (XL184)
    CAS: 1140909-48-3
    纯度: >99.50%

    A VEGFR2 inhibitor

  • GC12539 structure
    GC12539BLZ945
    CAS: 953769-46-5
    纯度: >99.50%

    A selective inhibitor of CSF1R

  • GC12590 structure
    GC12590KRN 633
    CAS: 286370-15-8
    纯度: >99.00%

    A VEGF receptor tyrosine kinase inhibitor

  • GC12616 structure
    GC12616Crizotinib hydrochloride
    CAS: 1415560-69-8
    纯度: >98.00%

    Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂，IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化，IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。

  • GC12686 structure
    GC12686SU 16f
    CAS: 251356-45-3
    纯度: >98.00% / >99.50%

    SU 16f是一种有效的酪氨酸激酶抑制剂，可抑制VEGF-R2、FGF-R1和PDGFRβ，IC 50 值分别为0.14、2.29和0.01μM。

  • GC12712 structure
    GC12712NT157
    CAS: 1384426-12-3

    NT157是一种具有选择性的胰岛素受体底物-1/-2（IRS-1/2）抑制剂。

  • GC12746 structure
    GC12746N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
    CAS: 159439-02-8

    Phosphopeptide ligand for the src SH2 domain

  • GC12818 structure
    GC128184-methyl Erlotinib
    CAS: 1346601-52-2

    A methylated analog of erlotinib

  • GC12857 structure
    GC12857R1530
    CAS: 882531-87-5
    纯度: >99.00%

    A multi-kinase inhibitor

  • GC12864 structure
    GC12864AG-1557
    CAS: 189290-58-2
    纯度: >99.50%

    An EGFR inhibitor

  • GC12910 structure
    GC12910Canertinib (CI-1033)
    CAS: 267243-28-7
    纯度: >99.50%

    Canertinib (CI-1033)是一种强效、不可逆的EGFR抑制剂，对EGFR、HER2和HER4的IC 50 值分别为0.8、19和7nM。

  • GC12955 structure
    GC12955AZ5104
    CAS: 1421373-98-9
    纯度: >98.00%

    An active metabolite of AZD 9291

  • GC12958 structure
    GC12958ER 27319 maleate
    CAS: 1204480-26-1
    纯度: >99.00%

    Syk激酶的选择性抑制剂

  • GC12963 structure
    GC12963NVP-AEW541
    CAS: 475489-16-8
    纯度: >98.50%

    An IGF-1R inhibitor

  • GC12977 structure
    GC12977Tyrphostin B44, (-) enantiomer
    CAS: 133550-32-0

    EGFR-kinase inhibitor

  • GC12980 structure
    GC12980CP-673451
    CAS: 343787-29-1
    纯度: >99.50%

    A selective PDGFRα/β kinase inhibitor

  • GC13136 structure
    GC13136(S)-Crizotinib
    CAS: 1374356-45-2
    纯度: >99.50%

    An MTH1 inhibitor

  • GC13143 structure
    GC13143AZD3759
    CAS: 1626387-80-1
    纯度: >99.50%

    A brain penetrant inhibitor of EGFR

  • GC13168 structure
    GC13168AG 825
    CAS: 149092-50-2
    纯度: >98.00%

    An inhibitor of Her2/Neu tyrosine kinase activity

  • GC13213 structure
    GC13213WZ3146
    CAS: 1214265-56-1
    纯度: >99.00%

    An inhibitor of mutant EGFR