Membrane Transporter/Ion Channel
Membrane Transporter/Ion Channel(跨膜转运)
- AMPAR(58)
- ATPase(80)
- Calcium Channel(331)
- Cannabinoid Transporters(6)
- CFTR(45)
- Chloride Channels(13)
- GABA Receptor(239)
- Gardos Channel(1)
- Glucose Transporters(13)
- Glutamate (EAAT) Transporters(18)
- Glycine Receptors(2)
- GlyT(19)
- GTPase(32)
- Kv1.3(1)
- ICB(2)
- Lipophilic platinum complex(1)
- M2 ion Channel(1)
- MCT2(2)
- Monoamine transporter(18)
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- Na+/Ca2+ Exchanger(16)
- NKCC(7)
- NMDA Receptor(81)
- Nucleoside Transporters(4)
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- Proton Pump(56)
- Potassium Channel(308)
- Sodium Channel(211)
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- MCT(3)
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- Ionophore(3)
- sodium-hydrogen exchanger(3)
- Chloride Channel(27)
- CRAC Channel(13)
- EAAT2(6)
- HCN Channel(6)
- Na+/HCO3- Cotransporter(1)
- Na+/K+ ATPase(28)
- P-glycoprotein(49)
- iGluR(164)
- nAChR(103)
- VDAC(2)
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- GlyR(1)
- Ferroportin(1)
- Urea Transporter(1)
- Na+/H+ Exchanger (NHE)(1)
- NTPDase(1)
- EAAT(1)
- Piezo Channel(1)
- ASCT(2)
Membrane Transporter/Ion Channel 相关产品(2265)
- GC39553KCC2 blocker 1CAS: 1228439-36-8纯度: >98.50%
KCC2 blocker 1 是一种口服有效的，选择性的 K+-Cl- 共转运蛋白 KCC2 阻滞剂，IC50 为 1 μM。KCC2 blocker 1 是一种脯氨酸苄酯，具有抗癫痫作用。
- GC39618Mexiletine D6 hydrochlorideCAS: 1329835-60-0纯度: >98.00%
Mexiletine D6 hydrochloride (KOE-1173 D6 hydrochloride) 是 Mexiletine hydrochloride (KOE-1173 hydrochloride) 的氘代物。Mexiletine hydrochloride，一种 Class IB 类抗心律失常化合物，是钠离子通道 (voltage-gated sodium channel) 阻断剂。
- GC39646Carboxyamidotriazole OrotateCAS: 187739-60-2纯度: >99.50%
A non-selective calcium channel blocker
- GC39699Aurintricarboxylic acidCAS: 4431-00-9
A protein synthesis inhibitor with diverse biological activities
- GC39701ConvallatoxinCAS: 508-75-8纯度: >98.00%
Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物，并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂，具有很高的效力和功效。具有抗炎和抗增殖特性。
- GC39743Bepridil hydrochloride hydrateCAS: 74764-40-2纯度: >98.00%
Bepridil hydrochloride hydrate是一种长效的钙通道阻滞剂。
- GC39748Facinicline hydrochlorideCAS: 677305-02-1纯度: >99.50%
Facinicline hydrochloride (RG3487 hydrochloride) 是具有口服活性的烟碱 α7 receptor 部分激动剂，对人nAChR 的 Ki 值为 6 nM。Facinicline hydrochloride (RG3487 hydrochloride) 可改善啮齿类动物的认知和感觉运动门控。Facinicline hydrochloride (RG3487 hydrochloride) 对5-HT3 受体 (拮抗剂)的Ki 值为 1.2 nM。
- GC39810CID44216842CAS: 1222513-26-9纯度: >99.50%
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.
- GC39843Ropivacaine mesylateCAS: 854056-07-8纯度: >98.00%
Ropivacaine mesylate 是一种氨基酰胺化合物，有阻断神经性疼痛的作用。Ropivacaine mesylate 是一种 K2P (双孔钾通道) TREK-1 抑制剂，在 COS-7 细胞膜上其 IC50 值为 402.7 μM。Ropivacaine mesylate 能在急性高血压模型中抑制压力诱导的肺内皮细胞高通透性。
- GC39848Indole-2-carboxylic acidCAS: 1477-50-5纯度: >99.50%
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation.
- GC40180Tetrabenazine-d6CAS: 1392826-25-3纯度: >99.00%
An internal standard for the quantification of tetrabenazine
- GC40207Nifedipine-d6CAS: 1188266-14-9纯度: >99.00%
An internal standard for the quantification of nifedipine
- GC40434(±)16-HETECAS: 128914-46-5纯度: >98.00%
A potent inhibitor of proximal tubule ATPase activity
- GC40438(±)5(6)-EETCAS: 87173-80-6纯度: >95.00%
A racemic version of a CYP450 metabolite of arachidonic acid
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC39546 | Bevantolol hydrochloride | 42864-78-8 | >98.00% | |
A β1-AR antagonist | ||||
| GC39553 | KCC2 blocker 1 | 1228439-36-8 | >98.50% | |
KCC2 blocker 1 是一种口服有效的，选择性的 K+-Cl- 共转运蛋白 KCC2 阻滞剂，IC50 为 1 μM。KCC2 blocker 1 是一种脯氨酸苄酯，具有抗癫痫作用。 | ||||
| GC39618 | Mexiletine D6 hydrochloride | 1329835-60-0 | >98.00% | |
Mexiletine D6 hydrochloride (KOE-1173 D6 hydrochloride) 是 Mexiletine hydrochloride (KOE-1173 hydrochloride) 的氘代物。Mexiletine hydrochloride，一种 Class IB 类抗心律失常化合物，是钠离子通道 (voltage-gated sodium channel) 阻断剂。 | ||||
| GC39646 | Carboxyamidotriazole Orotate | 187739-60-2 | >99.50% | |
A non-selective calcium channel blocker | ||||
| GC39648 | H3B-120 | 2194903-42-7 | >98.00% | |
H3B-120 is a competitive, selective and allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 1.5 μM and Ki of 1.4 μM. H3B-120 exhibits anti-tumor activity. | ||||
| GC39699 | Aurintricarboxylic acid | 4431-00-9 | - | |
A protein synthesis inhibitor with diverse biological activities | ||||
| GC39701 | Convallatoxin | 508-75-8 | >98.00% | |
Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物，并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂，具有很高的效力和功效。具有抗炎和抗增殖特性。 | ||||
| GC39719 | Nigericin | 28380-24-7 | >98.00% / >97.00% | |
A potassium ionophore | ||||
| GC39734 | Diphyllin | 22055-22-7 | >99.50% | |
A lignan with diverse biological activities | ||||
| GC39743 | Bepridil hydrochloride hydrate | 74764-40-2 | >98.00% | |
Bepridil hydrochloride hydrate是一种长效的钙通道阻滞剂。 | ||||
| GC39748 | Facinicline hydrochloride | 677305-02-1 | >99.50% | |
Facinicline hydrochloride (RG3487 hydrochloride) 是具有口服活性的烟碱 α7 receptor 部分激动剂，对人nAChR 的 Ki 值为 6 nM。Facinicline hydrochloride (RG3487 hydrochloride) 可改善啮齿类动物的认知和感觉运动门控。Facinicline hydrochloride (RG3487 hydrochloride) 对5-HT3 受体 (拮抗剂)的Ki 值为 1.2 nM。 | ||||
| GC39792 | Halazone | 80-13-7 | - | |
Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water. | ||||
| GC39806 | Isotachysterol 3 | 22350-43-2 | >98.50% | |
An impurity in the preparation of vitamin D 3 | ||||
| GC39810 | CID44216842 | 1222513-26-9 | >99.50% | |
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively. | ||||
| GC39843 | Ropivacaine mesylate | 854056-07-8 | >98.00% | |
Ropivacaine mesylate 是一种氨基酰胺化合物，有阻断神经性疼痛的作用。Ropivacaine mesylate 是一种 K2P (双孔钾通道) TREK-1 抑制剂，在 COS-7 细胞膜上其 IC50 值为 402.7 μM。Ropivacaine mesylate 能在急性高血压模型中抑制压力诱导的肺内皮细胞高通透性。 | ||||
| GC39848 | Indole-2-carboxylic acid | 1477-50-5 | >99.50% | |
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. | ||||
| GC40180 | Tetrabenazine-d6 | 1392826-25-3 | >99.00% | |
An internal standard for the quantification of tetrabenazine | ||||
| GC40207 | Nifedipine-d6 | 1188266-14-9 | >99.00% | |
An internal standard for the quantification of nifedipine | ||||
| GC40377 | 20-HEPE | 116477-57-7 | >95.00% | |
An EPA metabolite | ||||
| GC40434 | (±)16-HETE | 128914-46-5 | >98.00% | |
A potent inhibitor of proximal tubule ATPase activity | ||||
| GC40438 | (±)5(6)-EET | 87173-80-6 | >95.00% | |
A racemic version of a CYP450 metabolite of arachidonic acid | ||||
| GC40453 | 16(R)-HETE | 183509-22-0 | >95.00% | |
A potent vasodilator | ||||
| GC40454 | 16(S)-HETE | 183509-23-1 | >98.00% | |
A potent inhibitor of proximal tubule ATPase activity | ||||
| GC40455 | 17(R)-HETE | 183509-24-2 | >98.00% | |
An inactive isomer of 17-HETE | ||||