GlpBio

Na+/K+ ATPase

Na+/K+ ATPase(Na+/K+ ATP酶)

Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase 相关产品(27)

  • GC10579 structure
    GC10579Ouabain Octahydrate
    CAS: 11018-89-6
    纯度: >99.50%

    Ouabain Octahydrate是一种Na + /K + -ATPase抑制剂，能够用于研究充血性心力衰竭。

  • GC11448 structure
    GC11448Istaroxime
    CAS: 203737-93-3

    Istaroxime (PST2744) 是一种有效的 Na+,K+-ATPase 抑制剂，IC50 为 0.11 μM。

  • GC12413 structure
    GC12413Rostafuroxin (PST 2238)
    CAS: 156722-18-8
    纯度: >98.00%

    An endogenous ouabain blocker at the Na + /K + ATPase

  • GC13108 structure
    GC13108Digoxin
    CAS: 20830-75-5
    纯度: >98.50%

    地高辛（Digoxin）是一种强效的Na + /K + -ATP酶抑制剂，临床用于治疗心律失常和心力衰竭。

  • GC13162 structure
    GC13162Prilocaine hydrochloride
    CAS: 1786-81-8

    An Analytical Reference Standard

  • GC15071 structure
    GC15071Prilocaine
    CAS: 721-50-6
    纯度: >99.00%

    An Analytical Reference Standard

  • GC17086 structure
    GC17086Chlorpropamide
    CAS: 94-20-2
    纯度: >99.50%

    A first generation sulfonylurea

  • GC17786 structure
    GC17786Istaroxime hydrochloride
    CAS: 374559-48-5
    纯度: >99.00%

    Istaroxime hydrochloride 是 Na+/K+-ATPase 抑制剂 (IC50=0.11 μM) 和肌质/内质网钙 ATPase 2 (SERCA 2) 激活剂。

  • GC18189 structure
    GC18189Marinobufagenin
    CAS: 470-42-8
    纯度: >99.00%

    An α 1 Na + /K + ATPase sodium pump inhibitor

  • GC18203 structure
    GC18203Annonacin
    CAS: 111035-65-5
    纯度: >98.00%

    A mitochondrial complex I inhibitor

  • GC19522 structure
    GC19522Sodium oleate
    CAS: 143-19-1
    纯度: >97.00%

    A monounsaturated fatty acid

  • GC30110 structure
    GC30110Oleic acid (9-cis-Octadecenoic acid)
    CAS: 112-80-1
    纯度: >98.00%

    油酸（9-顺式-十八碳烯酸）是一种单不饱和的Omega-9脂肪酸，存在于植物和动物中。

  • GC30535 structure
    GC30535Transdermal Peptide (TD 1 (peptide))
    CAS: 918629-48-8

    Transdermal Peptide (TD 1 (peptide)) 由 11 个氨基酸组成，是第一个通过噬菌体展示发现的透皮增强肽。

  • GC30927 structure
    GC30927Acevaltrate
    CAS: 25161-41-5
    纯度: >98.00%

    Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.

  • GC32130 structure
    GC32130(+)-SJ733 (SJ000557733)
    CAS: 1424799-20-1
    纯度: >99.00%

    (+)-SJ733 (SJ000557733) 是一种抗疟疾药物，还可以抑制 Na+-ATPase PfATP4。

  • GC34013 structure
    GC34013Digitoxin
    CAS: 71-63-6
    纯度: >99.00%

    Digitoxin是一种天然存在的心脏糖苷类和抗癌剂，主要从 Digitalis lanata 中提取。Digitoxin能有效抑制1型单纯疱疹病毒（HSV-1）复制，其EC 50 值为0.05μM，并在48h内对HeLa宫颈癌细胞表现出最高的细胞毒性，IC 50 为28nM。

  • GC38869 structure
    GC38869Transdermal Peptide TFA

    Transdermal Peptide TFA (TD 1 peptide TFA) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide TFA 能够增强一些大分子在皮肤中的传递。

  • GC38903 structure
    GC38903Deslanoside
    CAS: 17598-65-1
    纯度: >98.00%

    A cardiac glycoside

  • GC41514 structure
    GC41514Citreoviridin
    CAS: 25425-12-1
    纯度: >95.00%

    A mycotoxin that inhibits the mitochondrial ATPase

  • GC61345 structure
    GC61345Transdermal Peptide Disulfide TFA
    纯度: >98.00%

    TransdermalPeptideDisulfideTFA(TD1Disulfide(peptide)TFA)是由11个氨基酸组成的多肽，可以与Na+/K+-ATPasebeta-subunit(ATP1B1)结合，主要与ATP1B1的C末端相互作用。TransdermalPeptideDisulfideTFA能够增强一些大分子在皮肤中的传递。

  • GC61628 structure
    GC61628Neriifolin
    CAS: 466-07-9
    纯度: >96.00%

    Neriifolin是一种穿透中枢神经系统的强心苷，是一种Na+,K+-ATPase的抑制剂。Neriifolin可靶向beclin1，抑制LC3相关吞噬体的形成，改善实验性自身免疫性脑脊髓炎(EAE)的发展。Neriifolin诱导人肝癌HepG2细胞周期阻滞和凋亡。

  • GC63832 structure
    GC63832Strophanthidin
    CAS: 66-28-4
    纯度: >92.00%

    Strophanthidin 是一种天然的心脏糖苷。Strophanthidin 0.1 和 1 nmol/L 增加 Na+/K+-ATPase 活性，1~100 μ mol/L 抑制 Na+/K+-ATPase 活性，而 Strophanthidin 10 和 100 nmol/L 对 Na+/K+-ATPase活性无影响。Strophanthidin 增加舒张期和收缩期胞内 Ca2+ 浓度。

  • GC64887 structure
    GC64887Gitoxin
    CAS: 4562-36-1
    纯度: >95.00%

    Gitoxin 是 Na+/K+-ATPase 的抑制剂，是Digitoxin 的降解代谢物，因ZOH 基团靠近C-17β 位置，可改善药代动力学和药效学数据。

  • GN10029 structure
    GN10029Phloridzin
    CAS: 60-81-1
    纯度: >98.00%

    An inhibitor of sodium-glucose cotransporters