GlpBio

Chloride Channel

Chloride Channel(氯离子通道)

Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

Chloride Channel 相关产品(27)

  • GC11069 structure
    GC11069Meticrane
    CAS: 1084-65-7
    纯度: >98.00%

    Meticrane 是一种利尿剂。

  • GC13466 structure
    GC13466Flufenamic acid
    CAS: 530-78-9
    纯度: >99.50%

    An NSAID and COX inhibitor

  • GC14073 structure
    GC14073DCPIB
    CAS: 82749-70-0
    纯度: >99.50%

    A VRAC inhibitor

  • GC14268 structure
    GC14268NPPB
    CAS: 107254-86-4
    纯度: >99.50% / >98.00%

    NPPB是一种强效的氯通道抑制剂，对短路电流的IC 50 为80nM。

  • GC14768 structure
    GC14768CaCCinh-A01
    CAS: 407587-33-1
    纯度: >99.50%

    CaCCinh-A01是一种钙激活氯通道（CaCC）TMEM16A抑制剂，对TMEM16A电流的IC 50 值为7.35 ± 0.86μM。

  • GC15308 structure
    GC15308IAA-94
    CAS: 54197-31-8
    纯度: >99.50% / >98.00%

    IAA-94 (Indanyloxyacetic acid-94) 是一种细胞内氯离子通道阻滞剂。

  • GC16564 structure
    GC16564Niflumic acid
    CAS: 4394-00-7
    纯度: >99.50%

    A selective COX-2 inhibitor

  • GC16890 structure
    GC16890Lubiprostone
    CAS: 136790-76-6
    纯度: >98.00%

    A ClC-2 activator

  • GC17930 structure
    GC17930T16Ainh - A01
    CAS: 552309-42-9
    纯度: >99.00% / >98.50%

    An inhibitor of TMEM16A channels

  • GC18142 structure
    GC18142Eact
    CAS: 461000-66-8
    纯度: >98.00%

    Eact是一种高特异性、强效的TMEM16A激活剂，能在钙离子浓度升高时激活TMEM16A。

  • GC18358 structure
    GC18358MONNA
    CAS: 1572936-83-4

    MONNA是ANO1（anoctamin-1/TMEM16A）钙激活氯通道的特异性阻断剂，对非洲爪蟾卵母细胞中xANO1的IC 50 为0.08μM。

  • GC19021 structure
    GC19021Adjudin
    CAS: 252025-52-8
    纯度: >98.00%

    A derivative of lonidamine

  • GC30555 structure
    GC30555H100
    CAS: 643727-55-3

    H100是一种氯离子运输(Cl-transport)抑制剂，可以部分抑制氯离子载体NaK2Clcotransporter和Band3anionexchanger，但是对KClcotransporter无作用。

  • GC31133 structure
    GC31133NS1652
    CAS: 1566-81-0
    纯度: >99.50%

    NS1652是一种可逆的阴离子电导(anionconductance)抑制剂，在人和小鼠的红细胞中，可以抑制氯离子通道(chloridechannel)，IC50值为1.6μM。

  • GC33024 structure
    GC33024Chlorotoxin
    CAS: 163515-35-3
    纯度: >98.00%

    Chlorotoxin是一种从以色列杀人蝎毒液中分离的多肽毒素。

  • GC34574 structure
    GC34574Endovion
    CAS: 265646-85-3
    纯度: >99.00%

    Endovion (NS 3728, SCO-101) is a potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).

  • GC38498 structure
    GC38498Chlorotoxin (TFA)

    Chlorotoxin TFA 是从蝎子毒液中分离到的多肽，为氯离子通道 (chloride channel) 阻断剂。Chlorotoxin TFA 具有抗癌作用。

  • GC46086 structure
    GC46086Ani 9
    CAS: 356102-14-2
    纯度: >98.00%

    Ani 9是一种高选择性的ANO1抑制剂，可有效阻断ANO1通道活性，对ANO1的IC₅₀值小于3μM。

  • GC60834 structure
    GC60834Fenamic acid
    CAS: 91-40-7
    纯度: >98.00%

    Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.

  • GC61186 structure
    GC61186Picrotoxinin
    CAS: 17617-45-7
    纯度: >98.00%

    Picrotoxinin是一种来源于天然植物的苦味毒素，存在于一种名为 Anamirta cocculus 的攀援植物的种子中，是一种氯离子通道阻断剂。Picrotoxinin是一种非竞争性的GABA A 受体拮抗剂，负向调节神经递质γ氨基丁酸（GABA）对GABA A 受体的作用。

  • GC63514 structure
    GC63514Irisolidone
    CAS: 2345-17-7
    纯度: >99.50%

    Irisolidone 是葛根花中的主要的异黄酮。Irisolidone 具有较强的保肝活性。Irisolidone 对阴离子通道 VRAC 具有高效阻断作用。

  • GC65406 structure
    GC65406T16A(inh)-C01
    CAS: 171506-87-9

    T16A(inh)-C01 是一种 TMEM16A (ANO1) 抑制剂。T16A(inh)-C01 不干扰钙信号转导，并能阻断TMEM16A 介导的氯离子电流，IC50 为 8.4 μM。

  • GC68663 structure
    GC68663ANO1-IN-1
    CAS: 407587-01-3
    纯度: >98.00%

    ANO1-IN-1 (Compound 9c) 是一种选择性的 ANO1 通道阻断剂，对 ANO1 和 ANO2 的 IC50 值分别为 2.56 μM 和 15.43 μM。ANO1-IN-1 强烈抑制胶质瘤细胞的增殖。

  • GC70963 structure
    GC70963DFBTA
    CAS: 2966044-07-3
    纯度: >98.00%

    DFBTA是一种口服有效的、有效的、小脑渗透的ANO1(钙活化氯通道anotamin -1)抑制剂，IC50为24 nM。