GlpBio

CRAC Channel

CRAC Channel(钙释放激活钙通道)

The Ca2+ release-activated Ca2+ (CRAC) channel is a highly Ca2+-selective store-operated channel expressed in T cells, mast cells, and various other tissues. CRAC channels regulate critical cellular processes such as gene expression, motility, and the secretion of inflammatory mediators. The identification of Orai1, a key subunit of the CRAC channel pore, and STIM1, the endoplasmic reticulum (ER) Ca2+ sensor, have provided the tools to illuminate the mechanisms of regulation and the pore properties of CRAC channels. Opening of CRAC channels enables the refilling of ER Ca2+ stores and sustains long-lasting Ca2+ oscillations and plateau signals, critical for the proliferation of T cells and production of cytokines following antigenic stimulation.

CRAC Channel 相关产品(13)

  • GC11683 structure
    GC11683MRS 1845
    CAS: 544478-19-5
    纯度: >98.00%

    An inhibitor of SOC and Ca v 1 channels

  • GC14665 structure
    GC14665YM 58483
    CAS: 223499-30-7
    纯度: >98.00%

    YM 58483是一种吡唑衍生的CRAC通道抑制剂，能抑制Ca 2+ 信号，IC 50 值为100nM。

  • GC19107 structure
    GC19107CM-4620
    CAS: 1713240-67-5
    纯度: >99.50% / >98.00%

    CM-4620是一种选择性Orai通道抑制剂，对Orai1和Orai2的IC 50 值分别为0.119μM和0.895μM。

  • GC30361 structure
    GC30361CRAC intermediate 2
    CAS: 123066-64-8
    纯度: >99.50%

    CRACintermediate2是摘自专利WO2013059666A1中用于CRAC系列抑制剂合成的中间体。

  • GC31680 structure
    GC31680GSK-5498A
    CAS: 1253186-49-0
    纯度: >98.00%

    GSK-5498A是CARC离子通道选择性小分子抑制剂(IC50=1_mu_M)；抑制肥大细胞介质释放和T细胞促炎性细胞因子的释放。

  • GC31852 structure
    GC31852CRAC intermediate 1
    CAS: 1249343-86-9
    纯度: >98.00%

    CRACintermediate1是从专利WO2010122089摘取出的关键中间体，用于CRAC离子通道系列化合物的合成。

  • GC33472 structure
    GC33472Synta66
    CAS: 835904-51-3
    纯度: >99.00%

    Synta66是钙离子通道Orai(CRAC的核心)的抑制剂，主要用于神经疾病的研究。

  • GC37658 structure
    GC37658SOCE inhibitor 1
    CAS: 2169316-15-6
    纯度: >99.50%

    SOCE inhibitor 1是钙库调控的钙通道抑制剂，IC50为4.4 μM。

  • GC50179 structure
    GC501795J 4
    CAS: 827001-82-1

    5J 4 是一种有效的 CRAC 抑制剂。

  • GC60327 structure
    GC60327RO2959 hydrochloride
    CAS: 1219927-22-6

    RO2959hydrochloride是一种有效的选择性CRAC通道抑制剂，IC50为402nM。RO2959hydrochloride是由Orai1/Stim1通道介导的钙存储进入(SOCE)的有效阻滞剂，IC50为25nM。RO2959hydrochloride还是人IL-2产生的有效抑制剂，有效阻断T细胞受体触发的基因表达和T细胞功能途径。

  • GC61248 structure
    GC61248RO2959 monohydrochloride
    CAS: 2309172-44-7
    纯度: >99.00%

    RO2959monohydrochloride是一种有效的选择性CRAC通道抑制剂，IC50为402nM。RO2959monohydrochloride是由Orai1/Stim1通道介导的钙存储进入(SOCE)的有效阻滞剂，IC50为25nM。RO2959monohydrochloride还是人IL-2产生的有效抑制剂，有效阻断T细胞受体触发的基因表达和T细胞功能途径。

  • GC65999 structure
    GC65999piCRAC-1
    CAS: 2418049-54-2

    piCRAC-1 是一种有效的、光诱导型钙释放激活钙通道 (CRAC channel) 抑制剂。piCRAC-1 可缓解血小板减少和出血。

  • GN10809 structure
    GN10809Tanshinone IIA sulfonate sodium
    CAS: 69659-80-9
    纯度: >98.00%

    A tanshinone IIA derivative with immunomodulatory activity