P-glycoprotein
P-glycoprotein(P糖蛋白)
P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.
P-glycoprotein 相关产品(49)
- GC12986RisperidoneCAS: 106266-06-2纯度: >98.00%
Risperidone是一种5-羟色胺5-HT₂受体阻断剂、P-糖蛋白抑制剂和强效多巴胺D₂受体拮抗剂，对5-HT₂A和多巴胺D₂受体的Ki值分别为4.8nM和5.9nM。
- GC13375Dofequidar fumarateCAS: 153653-30-6纯度: >98.00%
A quinoline derivative and inhibitor of multidrug resistance
- GC30033Sinapine thiocyanateCAS: 7431-77-8纯度: >99.00%
Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.
- GC32518Norverapamil hydrochloride ((±)-Norverapamil hydrochloride)CAS: 67812-42-4纯度: >98.00%
An L-type calcium channel blocker
- GC32593Zamicastat (BIA 5-1058)CAS: 1080028-80-3纯度: >98.00%
Zamicastat (BIA 5-1058) (BIA 5-1058) 是一种多巴胺 β-羟化酶 (DBH) 抑制剂，可穿过血脑屏障 (BBB) 引起中枢和外周效应。
- GC33185Encequidar mesylate (HM30181 (mesylate))CAS: 849675-87-2纯度: >98.00%
HM30181 mesylate salt, a tetrazole derivative, is known as a P-glycoprotein inhibitor that has inhibitory activities on multidrug resistance in cancer cells.
- GC33338Biricodar (VX-710)CAS: 159997-94-1
Biricodar (VX-710) (VX-710) 是 P-糖蛋白和 MRP-1 的调节剂；在多重耐药细胞中显示出有效的化学增敏活性。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10240 | Atazanavir sulfate (BMS-232632-05) | 229975-97-7 | >99.50% | |
An inhibitor of HIV-1 protease | ||||
| GC10391 | Hypophyllanthin | 33676-00-5 | >98.00% | |
A P-glycoprotein inhibitor | ||||
| GC10928 | Tariquidar methanesulfonate, hydrate | 625375-83-9 | >98.00% | |
A P-glycoprotein inhibitor | ||||
| GC12523 | Reversan | 313397-13-6 | - | |
MST-312 是一种端粒酶抑制剂。 MST-312 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的化学改性衍生物。 MST-312可用于癌症研究，例如多发性骨髓瘤（MM）。 | ||||
| GC12945 | Atazanavir | 198904-31-3 | - | |
An inhibitor of HIV-1 protease | ||||
| GC12986 | Risperidone | 106266-06-2 | >98.00% | |
Risperidone是一种5-羟色胺5-HT₂受体阻断剂、P-糖蛋白抑制剂和强效多巴胺D₂受体拮抗剂，对5-HT₂A和多巴胺D₂受体的Ki值分别为4.8nM和5.9nM。 | ||||
| GC13375 | Dofequidar fumarate | 153653-30-6 | >98.00% | |
A quinoline derivative and inhibitor of multidrug resistance | ||||
| GC15570 | Tariquidar | 206873-63-4 | >98.50% | |
Tariquidar是一种高效、选择性的P-糖蛋白抑制剂，K D 值为5.1nM。 | ||||
| GC16609 | LY335979 (Zosuquidar 3HCL) | 167465-36-3 | >99.50% | |
A modulator of P-gp | ||||
| GC16672 | Zosuquidar | 167354-41-8 | >98.00% | |
A modulator of P-gp | ||||
| GC16677 | Valspodar | 121584-18-7 | >95.00% / >98.00% | |
Valspodar 是一种有效的 P-糖蛋白 (P-gp) 抑制剂，广泛用于临床前和临床研究 。 | ||||
| GC17163 | Elacridar hydrochloride | 143851-98-3 | >98.00% | |
An inhibitor of MRP-1 and BCRP | ||||
| GC17215 | Elacridar | 143664-11-3 | >98.00% | |
An inhibitor of MRP-1 and BCRP | ||||
| GC18460 | Roquefortine C | 58735-64-1 | - | |
A mycotoxin | ||||
| GC18470 | NSC 23925 | 858474-14-3 | >99.00% | |
An inhibitor of P-gp | ||||
| GC30033 | Sinapine thiocyanate | 7431-77-8 | >99.00% | |
Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities. | ||||
| GC30371 | Alisol F | 155521-45-2 | - | |
A triterpene with anti-inflammatory and hepatoprotective activities | ||||
| GC31340 | Encequidar (HM30181) | 849675-66-7 | >98.00% | |
An inhibitor of P-glycoprotein | ||||
| GC32518 | Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) | 67812-42-4 | >98.00% | |
An L-type calcium channel blocker | ||||
| GC32593 | Zamicastat (BIA 5-1058) | 1080028-80-3 | >98.00% | |
Zamicastat (BIA 5-1058) (BIA 5-1058) 是一种多巴胺 β-羟化酶 (DBH) 抑制剂，可穿过血脑屏障 (BBB) 引起中枢和外周效应。 | ||||
| GC32906 | Sinapine | 18696-26-9 | >99.50% | |
Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein. | ||||
| GC33151 | Polyoxyethylene stearate (POES) | 9004-99-3 | - | |
聚氧乙烯硬脂酸酯（POES）（POES）是一种非离子型乳化剂。 | ||||
| GC33185 | Encequidar mesylate (HM30181 (mesylate)) | 849675-87-2 | >98.00% | |
HM30181 mesylate salt, a tetrazole derivative, is known as a P-glycoprotein inhibitor that has inhibitory activities on multidrug resistance in cancer cells. | ||||
| GC33338 | Biricodar (VX-710) | 159997-94-1 | - | |
Biricodar (VX-710) (VX-710) 是 P-糖蛋白和 MRP-1 的调节剂；在多重耐药细胞中显示出有效的化学增敏活性。 | ||||