Alisol F is a triterpene that has been found in A. orientale and has anti-inflammatory and hepatoprotective activities.1,2 It reduces levels of inducible nitric oxide synthase (iNOS) and COX-2 and the production of TNF-α, IL-6,and IL-1β in LPS-stimulated RAW 264.7 cells.1 Alisol F (20 mg/kg) reduces plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, hepatic fibrosis, and hepatic levels of phosphorylated ERK in a mouse model of LPS/D-galactosamine-induced acute liver injury.1,2
1.Bi, X., Wang, P., Ma, Q., et al.Anti-inflammatory activities and liver protection of alisol F and 25-anhydroalisol F through the inhibition of MAPK, STAT3, and NF-κB activation in vitro and in vivoMolecules22(6)951(2017) 2.Choi, E., Jang, E., and Lee, J.-H.Pharmacological activities of Alisma orientale against nonalcoholic fatty liver disease and metabolic syndrome: Literature reviewEvid. Based Complement. Alternat. Med.2943162(2019)