iGluR

iGluR(离子型谷氨酸受体)

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR 相关产品(156)

GA10750 L-Glutamic acid
CAS: 56-86-0
纯度: >99.00%
L-Glutamic acid是哺乳动物中枢神经系统（CNS）中的主要兴奋性神经递质。L-Glutamic acid有两种主要类型的受体：离子型(NMDA-, AMPA- and kainate-selective iGluRs)和代谢型谷氨酸受体。L-Glutamic acid对突触后N-甲基-D-天冬氨酸受体的激动作用产生兴奋毒性，从而导致神经退行性病变。
GA10922 H-Gly-OH
CAS: 56-40-6
纯度: >99.00% / >99.50%
H-Gly-OH 是 CNS 中的一种抑制性神经递质，还与谷氨酸一起作为共激动剂，促进谷氨酰胺能 N-甲基-D-天冬氨酸 (NMDA) 受体的兴奋电位。
GA11306 H-D-Ser-OH
CAS: 312-84-5
纯度: >99.00%
An NMDA co-agonist
GA11338 H-D-Asp-OH
CAS: 1783-96-6
纯度: >99.00%
An amino acid and a precursor in NMDA biosynthesis
GC10198 Memantine hydrochloride
CAS: 41100-52-1
纯度: >98.00%
Memantine hydrochloride是一种非竞争性N-甲基-D-天冬氨酸受体（NMDAR）拮抗剂，IC 50 值为0.5-1μM。
GC10270 Noopept
CAS: 157115-85-0
纯度: >99.50%
An Analytical Reference Standard
GC10443 Meclofenoxate hydrochloride
CAS: 3685-84-5
纯度: >98.00%
A nootropic agent
GC10522 Felbamate
CAS: 25451-15-4
纯度: >98.00%
An inhibitor of NMDA receptors and a modulator of GABA A receptors
GC10781 7-Chlorokynurenic acid
CAS: 18000-24-3
纯度: >99.50%
A glycine-site selective NMDA receptor antagonist
GC11124 Lanicemine
CAS: 153322-05-5
纯度: >95.00%
A low-trapping NMDA channel blocker
GC11395 7-Chlorokynurenic acid sodium salt
CAS: 1263094-00-3
纯度: >99.50%
A glycine-site selective NMDA receptor antagonist
GC11470 Flupirtine maleate
CAS: 75507-68-5
纯度: >99.50%
An activator of Kv7 channels
GC11585 TCN 237 dihydrochloride
CAS: 700878-19-9
纯度: >98.00%
TCN 237 dihydrochloride 是一种有效的 NR2B 选择性 NMDA 拮抗剂，Ki 为 0.85 nM； NR2B Ca2+ 内流 IC50 为 9.7 nM；对 NR2A、NR2C、NR2D、hERG 通道和 α1-肾上腺素能受体无活性。
GC11715 Ibotenic acid
CAS: 2552-55-8
纯度: >99.00% / >98.00%
Ibotenic acid是一种神经毒素，对N-甲基-D-天冬氨酸（NMDA）和反式ACPD或代谢使君子酸（Qm）受体位点均具有激动剂活性。
GC11799 CNQX
CAS: 115066-14-3
纯度: >98.00%
CNQX是一种有效的竞争性AMPA /海藻酸酯受体(AMPA/kainate receptor)拮抗剂,IC50 分别为0.3µM和1.5µM。
GC11889 (S)-(-)-5-Fluorowillardiine
CAS: 140187-23-1
纯度: >95.00%
(S)-(-)-5-Fluorowillardiine 是一种有效且特异性的 AMPAR 激动剂。
GC12703 Philanthotoxin 74
CAS: 1227301-51-0
纯度: >98.00%
An AMPA receptor antagonist
GC12863 1-BCP
CAS: 34023-62-6
A positive allosteric modulator of AMPA receptors
GC13007 PEPA
CAS: 141286-78-4
纯度: >99.50%
A positive allosteric modulator of AMPA receptors
GC13010 LY451395
CAS: 375345-95-2
纯度: >99.50%
LY451395 (LY451395) 是一种有效且高度选择性的 AMPA 受体增强剂。
GC13164 Ampalex
CAS: 154235-83-3
纯度: >99.50%
An AMPA receptor modulator
GC13290 CMPDA
CAS: 380607-77-2
A positive allosteric modulator of GluA2
GC13349 Naspm trihydrochloride
CAS: 1049731-36-3
纯度: >98.00%
A synthetic analog of Joro spider toxin
GC13469 Piracetam
CAS: 7491-74-9
纯度: >99.00%
An Analytical Reference Standard

分类产品列表
货号	产品名称	CAS号	纯度
GA10750	L-Glutamic acid	56-86-0	>99.00%
GA10750	L-Glutamic acid是哺乳动物中枢神经系统（CNS）中的主要兴奋性神经递质。L-Glutamic acid有两种主要类型的受体：离子型(NMDA-, AMPA- and kainate-selective iGluRs)和代谢型谷氨酸受体。L-Glutamic acid对突触后N-甲基-D-天冬氨酸受体的激动作用产生兴奋毒性，从而导致神经退行性病变。
GA10922	H-Gly-OH	56-40-6	>99.00% / >99.50%
GA10922	H-Gly-OH 是 CNS 中的一种抑制性神经递质，还与谷氨酸一起作为共激动剂，促进谷氨酰胺能 N-甲基-D-天冬氨酸 (NMDA) 受体的兴奋电位。
GA11306	H-D-Ser-OH	312-84-5	>99.00%
GA11306	An NMDA co-agonist
GA11338	H-D-Asp-OH	1783-96-6	>99.00%
GA11338	An amino acid and a precursor in NMDA biosynthesis
GC10198	Memantine hydrochloride	41100-52-1	>98.00%
GC10198	Memantine hydrochloride是一种非竞争性N-甲基-D-天冬氨酸受体（NMDAR）拮抗剂，IC 50 值为0.5-1μM。
GC10270	Noopept	157115-85-0	>99.50%
GC10270	An Analytical Reference Standard
GC10443	Meclofenoxate hydrochloride	3685-84-5	>98.00%
GC10443	A nootropic agent
GC10522	Felbamate	25451-15-4	>98.00%
GC10522	An inhibitor of NMDA receptors and a modulator of GABA A receptors
GC10781	7-Chlorokynurenic acid	18000-24-3	>99.50%
GC10781	A glycine-site selective NMDA receptor antagonist
GC11124	Lanicemine	153322-05-5	>95.00%
GC11124	A low-trapping NMDA channel blocker
GC11395	7-Chlorokynurenic acid sodium salt	1263094-00-3	>99.50%
GC11395	A glycine-site selective NMDA receptor antagonist
GC11470	Flupirtine maleate	75507-68-5	>99.50%
GC11470	An activator of Kv7 channels
GC11585	TCN 237 dihydrochloride	700878-19-9	>98.00%
GC11585	TCN 237 dihydrochloride 是一种有效的 NR2B 选择性 NMDA 拮抗剂，Ki 为 0.85 nM； NR2B Ca2+ 内流 IC50 为 9.7 nM；对 NR2A、NR2C、NR2D、hERG 通道和 α1-肾上腺素能受体无活性。
GC11715	Ibotenic acid	2552-55-8	>99.00% / >98.00%
GC11715	Ibotenic acid是一种神经毒素，对N-甲基-D-天冬氨酸（NMDA）和反式ACPD或代谢使君子酸（Qm）受体位点均具有激动剂活性。
GC11799	CNQX	115066-14-3	>98.00%
GC11799	CNQX是一种有效的竞争性AMPA /海藻酸酯受体(AMPA/kainate receptor)拮抗剂,IC50 分别为0.3µM和1.5µM。
GC11889	(S)-(-)-5-Fluorowillardiine	140187-23-1	>95.00%
GC11889	(S)-(-)-5-Fluorowillardiine 是一种有效且特异性的 AMPAR 激动剂。
GC12703	Philanthotoxin 74	1227301-51-0	>98.00%
GC12703	An AMPA receptor antagonist
GC12863	1-BCP	34023-62-6	-
GC12863	A positive allosteric modulator of AMPA receptors
GC13007	PEPA	141286-78-4	>99.50%
GC13007	A positive allosteric modulator of AMPA receptors
GC13010	LY451395	375345-95-2	>99.50%
GC13010	LY451395 (LY451395) 是一种有效且高度选择性的 AMPA 受体增强剂。
GC13164	Ampalex	154235-83-3	>99.50%
GC13164	An AMPA receptor modulator
GC13290	CMPDA	380607-77-2	-
GC13290	A positive allosteric modulator of GluA2
GC13349	Naspm trihydrochloride	1049731-36-3	>98.00%
GC13349	A synthetic analog of Joro spider toxin
GC13469	Piracetam	7491-74-9	>99.00%
GC13469	An Analytical Reference Standard