GlpBio

Naspm trihydrochloride

目录号: GC13349纯度: >98.00%同义词: N-[3-[[4-[(3-氨基丙基)氨基]丁基]氨基]丙基]-1-萘乙酰胺三盐酸盐,1-Naphthylacetyl spermine trihydrochloride
A synthetic analog of Joro spider toxin
Naspm trihydrochloride
Cas No.: 1049731-36-3
规格价格库存数量操作
10mg¥1,215.00现货
1
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    641, 529–536 (2025)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

References:
[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1049731-36-3
同义词
N-[3-[[4-[(3-氨基丙基)氨基]丁基]氨基]丙基]-1-萘乙酰胺三盐酸盐,1-Naphthylacetyl spermine trihydrochloride
化学名
N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
SMILES
O=C(CC1=CC=CC2=CC=CC=C12)NCCCNCCCCNCCCN.Cl.Cl.Cl
分子式
C22H34N4O.3HCl
分子量
479.91 g/mol
溶解性
DMSO: 1.7 mg/mL,PBS (pH 7.2): 10 mg/mL
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol