GlpBio

TRP Channel

TRP Channel(瞬时受体电位离子通道)

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

TRP Channel 相关产品(162)

  • GC13218 structure
    GC13218TRPC6 inhibitor
    CAS: 1333207-63-8

    A TRPC6 channel blocker

  • GC15947 structure
    GC15947HC-030031
    CAS: 349085-38-7
    纯度: >98.00%

    HC-030031是瞬时受体电位锚蛋白亚家族成员1（TRPA1）的选择性抑制剂。HC-030031可阻断细胞的钙流入，对肉桂醛和异硫氰酸烯丙酯（AITC）诱导的钙内流的IC 50 值分别为4.9±0.1和7.5±0.2μM。

  • GC16882 structure
    GC16882Icilin
    CAS: 36945-98-9

    An agonist of CMR1/TRPM8

  • GC38465 structure
    GC38465GsMTx4
    CAS: 1209500-46-8
    纯度: >98.00%

    GsMTx4是一种由34个氨基酸组成的蜘蛛毒素肽，属于huwentoxin-1家族。

  • GC10188 structure
    GC101886'-Iodoresiniferatoxin
    CAS: 335151-55-8

    TRPV1 (VR1) vanilloid receptor partial agonist

  • GC10221 structure
    GC102219-Phenanthrol
    CAS: 484-17-3

    A TRPM4 inhibitor

  • GC10873 structure
    GC10873α-Spinasterol
    CAS: 481-18-5
    纯度: >99.00%

    A TRPV1 antagonist

  • GC11185 structure
    GC11185TCS 5861528
    CAS: 332117-28-9
    纯度: >99.00%

    A TRPA1 channel blocker

  • GC11293 structure
    GC11293PPAHV
    CAS: 175796-50-6

    vanilloid TRPV1 (VR1) receptor agonist

  • GC11318 structure
    GC11318Rosiglitazone maleate
    CAS: 155141-29-0
    纯度: >99.50%

    A PPARγ agonist

  • GC11613 structure
    GC11613L-R4W2
    CAS: 206350-79-0
    纯度: >99.00%

    L-R4W2 是香草素受体 1 (VR1, TRPV1) 的有效拮抗剂，IC50 为 0.1 μM。

  • GC11701 structure
    GC11701A 967079
    CAS: 1170613-55-4
    纯度: >99.00%

    A potent inhibitor of the TRPA1 channel

  • GC11906 structure
    GC11906Ononetin
    CAS: 487-49-0
    纯度: >95.00%

    A deoxybenzoin with diverse biological activities

  • GC11926 structure
    GC11926AMG 9810
    CAS: 545395-94-6
    纯度: >99.50%

    AMG 9810是一种高选择性和竞争性TRPV1拮抗剂（人：IC 50 = 24.5nM；小鼠：IC 50 = 85.6nM）。

  • GC12260 structure
    GC12260HC 067047
    CAS: 883031-03-6
    纯度: >99.00%

    HC 067047是TRPV4通道的选择性拮抗剂，对人、大鼠和小鼠TRPV4的IC 50 分别为48±6nM, 133±25nM和17±3nM。

  • GC12520 structure
    GC12520Diphenyleneiodonium chloride
    CAS: 4673-26-1
    纯度: >99.50%

    二苯碘铵 (DPI) 氯化物 (DPIC) 作为 NADH/NADPH 氧化酶抑制剂，对 Mtb 和 S. aureus 具有有效的抗菌活性。

  • GC12580 structure
    GC12580Polygodial
    CAS: 6754-20-7
    纯度: >98.00%

    A natural antifungal sesquiterpene

  • GC12597 structure
    GC12597Optovin
    CAS: 348575-88-2
    纯度: >99.00%

    A photoactivatable TRPA1 ligand

  • GC12783 structure
    GC12783Resiniferatoxin
    CAS: 57444-62-9
    纯度: >98.00% / >95.00% / >94.00%

    Resiniferatoxin (RTX)是一种超强辣椒素类似物,是一种结合瞬时受体电位通道,香草蛋白亚家族成员1 (TRPV1)的香草蛋白激动剂。

  • GC13003 structure
    GC13003AMG-517
    CAS: 659730-32-2
    纯度: >99.50%

    A TRPV1 antagonist

  • GC13457 structure
    GC13457ML 204
    CAS: 5465-86-1
    纯度: >98.00%

    A selective TRPC4 channel blocker

  • GC13679 structure
    GC136796-Iodonordihydrocapsaicin
    CAS: 859171-97-4

    Vanilloid receptor antagonist

  • GC13930 structure
    GC13930N-(p-amylcinnamoyl) Anthranilic Acid
    CAS: 110683-10-8

    A TRP channel blocker and PLA 2 inhibitor

  • GC13994 structure
    GC13994Phenamil
    CAS: 1161-94-0
    纯度: >98.00%

    Phenamil 是瞬时受体电位 (TRP) 和酸敏感离子通道 (ASIC) 的选择性抑制剂。