GlpBio

TRP Channel

TRP Channel(瞬时受体电位离子通道)

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

TRP Channel 相关产品(162)

  • GC17091 structure
    GC17091A 784168
    CAS: 824982-41-4

    A TRPV1 antagonist

  • GC17267 structure
    GC17267RN 1734
    CAS: 946387-07-1
    纯度: >98.00%

    A TRPV4 antagonist

  • GC17562 structure
    GC175622-APB
    CAS: 524-95-8
    纯度: >98.00%

    2-APB是一种钙离子通道的非特异性拮抗剂，通常被用于研究钙信号传导，如细胞凋亡、肌肉收缩和神经传导等方面。

  • GC17879 structure
    GC17879OLDA
    CAS: 105955-11-1
    纯度: >98.00%

    A synthetic endocannabinoid analog and potent 5-lipoxygenase inhibitor

  • GC17918 structure
    GC17918Capsazepine
    CAS: 138977-28-3
    纯度: >99.00%

    Capsazepine是瞬时受体电位香草素1（TRPV1）受体的特异性拮抗剂，IC 50 值为562 nM。

  • GC17940 structure
    GC17940GSK1016790A
    CAS: 942206-85-1
    纯度: >99.50% / >98.00%

    GSK1016790A是一种有效的选择性瞬时受体电位香草酸4（TRPV4）通道激动剂。

  • GC18020 structure
    GC18020AP 18
    CAS: 55224-94-7
    纯度: >98.00% / >99.50%

    A reversible channel blocker of TRPA1

  • GC18069 structure
    GC18069Cardamonin
    CAS: 19309-14-9
    纯度: >98.00%

    A chalconoid with anti-inflammatory and anti-tumor activity

  • GC18296 structure
    GC18296M8-B (hydrochloride)
    CAS: 883976-12-3
    纯度: >98.00%

    A selective TRPM8 antagonist

  • GC18564 structure
    GC18564MK6-83
    CAS: 1062271-24-2
    纯度: >99.00%

    A TRPML1 activator

  • GC19025 structure
    GC19025AM-0902
    CAS: 1883711-97-4
    纯度: >99.50%

    AM-0902 是一种有效的选择性瞬时受体电位 A1 (TRPA1) 拮抗剂，对 rTRPA1 和 hTRPA1 的 IC50 分别为 71 和 131 nM。

  • GC19291 structure
    GC19291PF-4840154
    CAS: 1332708-14-1
    纯度: >99.50%

    A TRPA1 channel agonist

  • GC19729 structure
    GC19729Adenosine 5′-diphosphoribose sodium
    CAS: 68414-18-6
    纯度: >99.00%

    Adenosine 5′-diphosphoribose sodium是一种核苷酸衍生物，是Transient receptor potential melastatin 2 (TRPM2)激动剂，在细胞内多种代谢途径中发挥着重要作用。

  • GC30096 structure
    GC30096Pyr10
    CAS: 1315323-00-2

    Pyr10是一种新型TRPC3选择性抑制剂,作用于转染YFP-TRPC3的HEK293细胞,抑制ROCE,IC50为0.72uM。

  • GC30546 structure
    GC30546TRPC6-IN-1
    CAS: 901715-05-7
    纯度: >99.50%

    TRPC6-IN-1是TRPC6的一个抑制剂，其EC50值为4.66μM。

  • GC30725 structure
    GC30725TRPV antagonist 1
    CAS: 1192871-27-4

    TRPVantagonist1是一种有效的瞬时受体电位V型(TRPV)拮抗剂，IC50值<250nM。

  • GC30799 structure
    GC30799HC-070
    CAS: 1628291-95-1
    纯度: >98.50%

    HC-070是一种瞬时受体电位通道蛋白4/5(TRPC4/TRPC5)拮抗剂，在细胞中，对hTRPC5和hTRPC4的IC50值分别为9.3nM和46nM。

  • GC30837 structure
    GC30837A-1165442
    CAS: 1221443-94-2
    纯度: >99.50%

    A-1165442是有效，竞争性，有口服活性的TRPV1拮抗剂，对人TRPV1的IC50值为9nM。

  • GC30893 structure
    GC30893TRPM8 Antagonist
    CAS: 259674-19-6
    纯度: >98.00%

    TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes.

  • GC31236 structure
    GC31236JYL 1421 (SC 0030)
    CAS: 401907-26-4

    A TRPV1 antagonist

  • GC31953 structure
    GC31953Camphor ((&plusmn;)-Camphor)
    CAS: 76-22-2
    纯度: >98.00%

    Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent.

  • GC32849 structure
    GC32849Pico145 (HC-608)
    CAS: 1628287-16-0
    纯度: >98.50%

    Pico145 (HC-608)是一种TRPC1/4/5通道抑制剂，可抑制(-)-englerin A激活的TRPC4/TRPC5通道，IC 50 值分别为0.349nM和1.3nM。

  • GC32961 structure
    GC32961D-3263 hydrochloride
    CAS: 1008763-54-9
    纯度: >98.00%

    D-3263hydrochloride是一种可口服的TRPM8激动剂。

  • GC33158 structure
    GC33158D-3263
    CAS: 947257-66-1

    D-3263是一种有效的TRPM8激动剂，具有抗肿瘤活性。