| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 5mg | ¥810.00 | 现货 | 1 | |
| 10mg | ¥1,350.00 | 现货 | 1 | |
| 25mg | ¥2,295.00 | 现货 | 1 | |
| 50mg | ¥3,420.00 | 现货 | 1 | |
| 100mg | ¥5,130.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥891.00 | 现货 | 1 |
TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes.
[1] Alessia Bertamino, et al. J Med Chem. 2018 Jul 26;61(14):6140-6152.
Animal experiment: | Mice[1]Icilin, a TRPM8 agonist, is dissolved in 20% DMSO and 1% Tween 80 in distilled water and injected intraperitoneally (i.p.) in a volume of 10 mL/kg. Each animal is acclimatized for 30 min for two consecutive days before icilin administration. TRPM8 antagonist 2 (compound 14) stock is prepared in DMSO and diluted in saline for injections. Gabapentin is dissolved in saline and administered s.c. at the dose of 25 mg/kg 60 min prior to icillin injection. Control animals receive the vehicle injection[1]. |
References: [1]. Bertamino A, et al. Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545. |
