TRP Channel

TRP Channel(瞬时受体电位离子通道)

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

TRP Channel 相关产品(162)

GC33423 JT010
CAS: 917562-33-5
纯度: >98.00%
A TRPA1 channel agonist
GC33424 SAR7334
CAS: 1333210-07-3
纯度: >99.50%
SAR7334是一种高效的TRPC6通道特异性抑制剂（IC 50 =7.9nM）。
GC33443 Pyr6
CAS: 245747-08-4
纯度: >99.00%
Pyr6 是 TRPC3 的选择性抑制剂，IC50 为 0.49 uM（在 thapsigargin 耗尽的天然 RBL-2H3 细胞中，Ca2+ 流入抑制）。
GC33675 Podocarpic acid
CAS: 5947-49-9
纯度: >98.00%
Podocarpicacid是一种天然产物，为TRPA1的激活剂，具有多种功效。
GC34489 BI-749327
CAS: 2361241-23-6
纯度: >98.00%
BI-749327是一种可口服利用的TRPC6拮抗剂，
GC34833 TC-I 2014
CAS: 1221349-53-6
纯度: >99.00%
TC-I2014(compound5)是一种强效的、苯并咪唑类的、TRPM8的拮抗剂，其对犬类、人和大鼠通道的IC50值分别为0.8nM,3.0nM和4.4nM。在疼痛动物模型中具有抗痛觉超敏作用。
GC34951 (-)-Menthol
CAS: 2216-51-5
纯度: >98.00%
A monoterpene with diverse biological activities
GC35010 (Z)-Capsaicin
CAS: 25775-90-0
纯度: >99.50%
Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.
GC35222 ABT-239
CAS: 460746-46-7
纯度: >99.00%
ABT-239 是一种新颖的，高效的，非咪唑类的 H3R 拮抗剂，也是 TRPV1 的拮抗剂。
GC35316 AMG2850
CAS: 1470018-52-0
AMG2850 是一个有效的、有口服活性的TRPM8 的选择性拮抗剂。
GC35407 Asivatrep
CAS: 1005168-10-4
纯度: >95.00%
Asivatrep是一种强效、选择性、非甾体类的transient receptor potential vanilloid subfamily V member 1 (TRPV1)拮抗剂。
GC35501 Beta-Eudesmol
CAS: 473-15-4
纯度: >98.00%
A sesquiterpene with diverse biological activities
GC35970 EIPA hydrochloride
CAS: 1345839-28-2
纯度: >99.00%
EIPA hydrochloride (L593754 hydrochloride) 是一种 TRPP3 channel 抑制剂，其 IC50 值为 10.5 μM。EIPA 还抑制 Na+/H+ 交换器 (NHE) 和巨噬细胞。
GC36277 Hydroxy-α-sanshool
CAS: 83883-10-7
纯度: >98.00%
Hydroxy-α-sanshool是一种TRPA1和TRPV1激动剂，其EC 50 值分别为69和1.1μM，常用于高脂血症的研究。
GC36609 Mifamurtide
CAS: 83461-56-7
纯度: >95.00%
Mifamurtide(CGP19835; MTP-PE)可作用于骨肉瘤。
GC36627 ML204 hydrochloride
CAS: 2070015-10-8
纯度: >99.50%
A selective TRPC4 channel blocker
GC37655 SN 2
CAS: 823218-99-1
纯度: >99.50%
SN 2 是一种有效的 TRPML3 离子通道激活剂，EC50 为 1.8±0.13 μM。
GC37831 TRPM8 agonist WS-3
CAS: 39711-79-0
纯度: >99.00%
Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM).
GC38501 GSK205
CAS: 1263068-83-2
纯度: >97.00%
GSK205是TRPV4离子通道的高选择性拮抗剂（IC 50 = 4.19μM）。
GC38726 1,4-Cineole
CAS: 470-67-7
纯度: >98.00% / >97.00%
1,4-Cineole (Isocineole) is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.
GC39117 Methyl syringate
CAS: 884-35-5
纯度: >99.50%
Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
GC39198 GSK1702934A
CAS: 924377-85-5
纯度: >98.00%
A TRPC3 and TRPC6 activator
GC40696 (R)-(+)-Pulegone
CAS: 89-82-7
纯度: >98.50% / >95.00% / >93.50% / >98.00%
A monoterpene with anti-inflammatory activity
GC40808 (+)-Menthol
CAS: 15356-60-2
纯度: >98.00%
A monoterpene alcohol with antifungal activity

分类产品列表
货号	产品名称	CAS号	纯度
GC33423	JT010	917562-33-5	>98.00%
GC33423	A TRPA1 channel agonist
GC33424	SAR7334	1333210-07-3	>99.50%
GC33424	SAR7334是一种高效的TRPC6通道特异性抑制剂（IC 50 =7.9nM）。
GC33443	Pyr6	245747-08-4	>99.00%
GC33443	Pyr6 是 TRPC3 的选择性抑制剂，IC50 为 0.49 uM（在 thapsigargin 耗尽的天然 RBL-2H3 细胞中，Ca2+ 流入抑制）。
GC33675	Podocarpic acid	5947-49-9	>98.00%
GC33675	Podocarpicacid是一种天然产物，为TRPA1的激活剂，具有多种功效。
GC34489	BI-749327	2361241-23-6	>98.00%
GC34489	BI-749327是一种可口服利用的TRPC6拮抗剂，
GC34833	TC-I 2014	1221349-53-6	>99.00%
GC34833	TC-I2014(compound5)是一种强效的、苯并咪唑类的、TRPM8的拮抗剂，其对犬类、人和大鼠通道的IC50值分别为0.8nM,3.0nM和4.4nM。在疼痛动物模型中具有抗痛觉超敏作用。
GC34951	(-)-Menthol	2216-51-5	>98.00%
GC34951	A monoterpene with diverse biological activities
GC35010	(Z)-Capsaicin	25775-90-0	>99.50%
GC35010	Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.
GC35222	ABT-239	460746-46-7	>99.00%
GC35222	ABT-239 是一种新颖的，高效的，非咪唑类的 H3R 拮抗剂，也是 TRPV1 的拮抗剂。
GC35316	AMG2850	1470018-52-0	-
GC35316	AMG2850 是一个有效的、有口服活性的TRPM8 的选择性拮抗剂。
GC35407	Asivatrep	1005168-10-4	>95.00%
GC35407	Asivatrep是一种强效、选择性、非甾体类的transient receptor potential vanilloid subfamily V member 1 (TRPV1)拮抗剂。
GC35501	Beta-Eudesmol	473-15-4	>98.00%
GC35501	A sesquiterpene with diverse biological activities
GC35970	EIPA hydrochloride	1345839-28-2	>99.00%
GC35970	EIPA hydrochloride (L593754 hydrochloride) 是一种 TRPP3 channel 抑制剂，其 IC50 值为 10.5 μM。EIPA 还抑制 Na+/H+ 交换器 (NHE) 和巨噬细胞。
GC36277	Hydroxy-α-sanshool	83883-10-7	>98.00%
GC36277	Hydroxy-α-sanshool是一种TRPA1和TRPV1激动剂，其EC 50 值分别为69和1.1μM，常用于高脂血症的研究。
GC36609	Mifamurtide	83461-56-7	>95.00%
GC36609	Mifamurtide(CGP19835; MTP-PE)可作用于骨肉瘤。
GC36627	ML204 hydrochloride	2070015-10-8	>99.50%
GC36627	A selective TRPC4 channel blocker
GC37655	SN 2	823218-99-1	>99.50%
GC37655	SN 2 是一种有效的 TRPML3 离子通道激活剂，EC50 为 1.8±0.13 μM。
GC37831	TRPM8 agonist WS-3	39711-79-0	>99.00%
GC37831	Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM).
GC38501	GSK205	1263068-83-2	>97.00%
GC38501	GSK205是TRPV4离子通道的高选择性拮抗剂（IC 50 = 4.19μM）。
GC38726	1,4-Cineole	470-67-7	>98.00% / >97.00%
GC38726	1,4-Cineole (Isocineole) is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.
GC39117	Methyl syringate	884-35-5	>99.50%
GC39117	Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
GC39198	GSK1702934A	924377-85-5	>98.00%
GC39198	A TRPC3 and TRPC6 activator
GC40696	(R)-(+)-Pulegone	89-82-7	>98.50% / >95.00% / >93.50% / >98.00%
GC40696	A monoterpene with anti-inflammatory activity
GC40808	(+)-Menthol	15356-60-2	>98.00%
GC40808	A monoterpene alcohol with antifungal activity