β-Eudesmol is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.1,2 It is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs) that decreases the open time and opening frequency of nAChR channels when used at concentrations of 40 and 80 ?M and increases the decay phase of depolarization when used at a concentration of 100 ?M in isolated mouse diaphragm muscle.3 β-Eudesmol (50-100 ?M) inhibits VEGF- and bFGF-induced proliferation in human umbilical vein endothelial cells (HUVECs).4 It also inhibits proliferation of HeLa, SGC-7901, and BEL-7402 cells when used at concentrations ranging from 10 to 100 ?M and reduces tumor growth in H22 and S-180 mouse tumor models when administered at doses ranging from 2.5 to 5 mg/kg. β-Eudesmol is an agonist of the transient receptor potential (TRP) receptor subtypes TRPA1, TRPV3, and TRPM8 and increases food intake and plasma levels of ghrelin in rats.5,6
1.Elzinga, S., Fischedick, J., Podkolinski, R., et al.Cannabinoids and terpenes as chemotaxonomic markers in CannabisNat. Prod. Chem. Res.3(4)181(2015) 2.Kimura, I.Medical benefits of using natural compounds and their derivatives having multiple pharmacological actionsYakugaku Zasshi126(3)133-143(2006) 3.Kimura, M., Nojima, H., Muroi, M., et al.Mechanism of the blocking action of β-eudesmol on the nicotinic acetylcholine receptor channel in mouse skeletal musclesNeuropharmacology30(8)835-841(1991) 4.Ma, E.L., Li, Y.C., Tsuneki, H., et al.β-Eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferationJ. Asian Nat. Prod. Res.10(1-2)159-167(2008) 5.Ohara, K., Fukada, T., Okada, H., et al.Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oilJ. Biol. Chem.290(5)3161-3171(2015) 6.Ohara, K., Fukuda, T., Ishida, Y., et al.β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous systemSci. Rep.7(1)15785(2017)