JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay).1 It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 ?M.
1.Takaya, J., Mio, K., Shiraishi, T., et al.A potent and site-selective agonist of TRPA1J. Am. Chem. Soc.137(50)15859-15864(2015)