GlpBio

TCS 5861528

目录号: GC11185纯度: >99.00%同义词: TCS 5861528
A TRPA1 channel blocker
TCS 5861528
Cas No.: 332117-28-9
规格价格库存数量操作
1mg¥158.00现货
1
5mg¥364.00现货
1
10mg¥552.00现货
1
25mg¥1,103.00现货
1
50mg¥1,677.00现货
1
100mg¥2,532.00现货
1
10mM (in 1mL DMSO)¥295.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

References:
[1]. Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54.
[2]. Wei H, et al. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 2010 Mar;58(3):578-84.
[3]. Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
332117-28-9
同义词
TCS 5861528
化学名
(R)-N-(4-(sec-butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide
SMILES
O=C1N(C)C(N(C)C(N=C2)=C1N2CC(NC3=CC=C(C=C3)[C@H](C)CC)=O)=O
分子式
C19H23N5O3
分子量
369.42 g/mol
溶解性
≥ 76 mg/mL in DMSO with ultrasonic and warming, ≥ 6.17 mg/mL in EtOH with ultrasonic and warming
保存条件
Store at RT
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol