GlpBio

HCN Channel

HCN Channel(HCN通道)

Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.

HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.

HCN Channel 相关产品(6)

  • GC10578 structure
    GC10578ZD 7288
    CAS: 133059-99-1
    纯度: >99.50% / >98.00%

    ZD 7288是一种超极化激活环核苷酸门控（HCN）通道阻滞剂。

  • GC16965 structure
    GC16965Zatebradine hydrochloride
    CAS: 91940-87-3
    纯度: >99.00%

    A bradycardic HCN channel blocker

  • GC18503 structure
    GC18503DK-AH 269
    CAS: 186097-54-1
    纯度: >98.00%

    An HCN channel blocker

  • GC32491 structure
    GC32491Zatebradine (UL-FS49)
    CAS: 85175-67-3
    纯度: >99.00%

    Zatebradine (UL-FS49) (UL-FS-49 (free base); UL-FS-49CL (free base)) 是一种有效的超极化激活环核苷酸门控 (HCN) 通道抑制剂，IC50 值为 1.96 μ ;M。

  • GC68799 structure
    GC68799BPU-11
    CAS: 909664-41-1
    纯度: >98.00%

    BPU-11 是一种 hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP 配体。BPU-11 可用于先天性免疫疾病的研究。

  • GC73927 structure
    GC73927KIO-301 chloride (hydrochloride)
    纯度: >99.00%

    KIO-301 chloride (hydrochloride)是一种偶氮苯光开关化合物，可阻断电压门控离子通道，包括过极化激活的环核苷酸门控和电压门控钾通道。