Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel(跨膜转运)

研究方向

Membrane Transporter/Ion Channel 相关产品(2265)

GC60530 5-Hydroxylansoprazole
CAS: 131926-98-2
纯度: >99.50%
5-Hydroxylansoprazole(AG1908)是血浆中Lansoprazole的活性代谢产物。Lansoprazole由CYP2C19代谢形成5-Hydroxylansoprazole。Lansoprazole是一种胃质子泵(proton-pump)抑制剂，可有效研究各种消化系统疾病。
GC60542 8-Gingerol
CAS: 23513-08-8
纯度: >99.50% / >99.00%
A natural TRPV1 agonist
GC60545 A2793
CAS: 88349-90-0
纯度: >99.50%
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
GC60549 ABT-418 hydrochloride
CAS: 147388-83-8
纯度: >99.50%
ABT-418hydrochloride是一种高效、选择性的nAChRs激动剂，具有增强认知和抗焦虑的作用。ABT-418hydrochloride激活胆碱能通道，可用于阿尔茨海默病的研究。
GC60596 Arecaidine
CAS: 499-04-7
纯度: >98.00%
Arecaidine，一种吡啶生物碱，是一种有效的GABA吸收抑制剂。Arecaidine是H+偶联的氨基酸转运蛋白1(PAT1，SLC36A1)的底物，竞争性抑制L-脯氨酸的摄取。
GC60642 Bifenthrin
CAS: 82657-04-3
纯度: >98.00%
Bifenthrin是一种拟除虫菊酯杀虫剂，其神经毒性作用的主要靶点是神经细胞膜的电压门控Na + 通道。
GC60709 Cinnarizine D8
CAS: 1185242-27-6
An internal standard for the quantification of cinnarizine
GC60718 Cloperastine hydrochloride
CAS: 14984-68-0
纯度: >99.00%
Cloperastine (HT-11) is a drug with a central antitussive effect, and is also endowed with an antihistaminic activity.
GC60723 COR659
CAS: 544450-68-2
纯度: >99.50%
COR659是GABAB的阳性变构调节剂(PAM)。COR659可缓解大鼠对酒精和巧克力的药物成瘾。
GC60750 Dehydrosoyasaponin I
CAS: 117210-14-7
纯度: >98.00%
DehydrosoyasaponinI(SoyasaponinBe;DHS-I)，一种三萜糖苷，是一种有效且可逆的钙激活钾(maxi-K)通道激活剂。
GC60834 Fenamic acid
CAS: 91-40-7
纯度: >98.00%
Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.
GC60862 GABAA receptor agent 1
CAS: 1571-87-5
纯度: >98.50%
GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.
GC60890 Guvacine
CAS: 498-96-4
An inhibitor of GABA uptake
GC60929 Ilaprazole sodium
CAS: 172152-50-0
纯度: >98.50%
A gastric proton pump inhibitor
GC60975 Lansoprazole Sulfide D4
CAS: 1216682-38-0
LansoprazoleSulfideD4是LansoprazoleSulfide的氘代物。LansoprazoleSulfide是质子泵抑制剂Lansoprazole的活性代谢产物。LansoprazoleSulfide是一种口服活性抗结核药，细胞内的IC50值为0.59µM，肉汤中的IC50值为0.46µM。
GC61046 Methocarbamol D5
CAS: 1189699-70-4
An internal standard for the quantification of methocarbamol
GC61066 Minoxidil sulfate
CAS: 83701-22-8
纯度: >99.50%
Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.
GC61110 Nav1.1 activator 1
CAS: 2332897-85-3
纯度: >98.00%
Nav1.1activator1(compound4)是强有效的、能透过血脑屏障的、Nav1.1激动剂，0.03μM可增加衰减Nav1.1电流的时间常数τ。对Nav1.2、Nav1.5、Nav1.6有显著的选择性。
GC61139 Nothofagin
CAS: 11023-94-2
Nothofagin是一种二氢查尔酮，是从如意宝(Aspalathuslinearis)中分离得到的。Nothofagin通过阻断钙(calcium)内流来下调NF-κB的转运。Nothofagin具有抗氧化活性，可改善各种炎症反应，例如脓毒症反应和血管炎症。
GC61141 NSC 15364
CAS: 4550-72-5
纯度: >98.00%
NSC15364是一种VDAC1寡聚化和细胞凋亡(apoptosis)抑制剂。
GC61155 Omeprazole sodium
CAS: 95510-70-6
纯度: >98.00%
An irreversible inhibitor of the gastric proton pump
GC61175 PF-06305591 dihydrate
CAS: 2703582-76-5
纯度: >99.00%
PF-06305591dihydrate是一种有效的、高选择性的电压门控钠通道NaV1.8的阻断剂，其IC50值为15nM。具有良好的临床前体外ADME(吸收、分布、代谢和排泄)和安全性。
GC61186 Picrotoxinin
CAS: 17617-45-7
纯度: >98.00%
Picrotoxinin是一种来源于天然植物的苦味毒素，存在于一种名为 Anamirta cocculus 的攀援植物的种子中，是一种氯离子通道阻断剂。Picrotoxinin是一种非竞争性的GABA A 受体拮抗剂，负向调节神经递质γ氨基丁酸（GABA）对GABA A 受体的作用。
GC61248 RO2959 monohydrochloride
CAS: 2309172-44-7
纯度: >99.00%
RO2959monohydrochloride是一种有效的选择性CRAC通道抑制剂，IC50为402nM。RO2959monohydrochloride是由Orai1/Stim1通道介导的钙存储进入(SOCE)的有效阻滞剂，IC50为25nM。RO2959monohydrochloride还是人IL-2产生的有效抑制剂，有效阻断T细胞受体触发的基因表达和T细胞功能途径。

分类产品列表
货号	产品名称	CAS号	纯度
GC60530	5-Hydroxylansoprazole	131926-98-2	>99.50%
GC60530	5-Hydroxylansoprazole(AG1908)是血浆中Lansoprazole的活性代谢产物。Lansoprazole由CYP2C19代谢形成5-Hydroxylansoprazole。Lansoprazole是一种胃质子泵(proton-pump)抑制剂，可有效研究各种消化系统疾病。
GC60542	8-Gingerol	23513-08-8	>99.50% / >99.00%
GC60542	A natural TRPV1 agonist
GC60545	A2793	88349-90-0	>99.50%
GC60545	A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
GC60549	ABT-418 hydrochloride	147388-83-8	>99.50%
GC60549	ABT-418hydrochloride是一种高效、选择性的nAChRs激动剂，具有增强认知和抗焦虑的作用。ABT-418hydrochloride激活胆碱能通道，可用于阿尔茨海默病的研究。
GC60596	Arecaidine	499-04-7	>98.00%
GC60596	Arecaidine，一种吡啶生物碱，是一种有效的GABA吸收抑制剂。Arecaidine是H+偶联的氨基酸转运蛋白1(PAT1，SLC36A1)的底物，竞争性抑制L-脯氨酸的摄取。
GC60642	Bifenthrin	82657-04-3	>98.00%
GC60642	Bifenthrin是一种拟除虫菊酯杀虫剂，其神经毒性作用的主要靶点是神经细胞膜的电压门控Na + 通道。
GC60709	Cinnarizine D8	1185242-27-6	-
GC60709	An internal standard for the quantification of cinnarizine
GC60718	Cloperastine hydrochloride	14984-68-0	>99.00%
GC60718	Cloperastine (HT-11) is a drug with a central antitussive effect, and is also endowed with an antihistaminic activity.
GC60723	COR659	544450-68-2	>99.50%
GC60723	COR659是GABAB的阳性变构调节剂(PAM)。COR659可缓解大鼠对酒精和巧克力的药物成瘾。
GC60750	Dehydrosoyasaponin I	117210-14-7	>98.00%
GC60750	DehydrosoyasaponinI(SoyasaponinBe;DHS-I)，一种三萜糖苷，是一种有效且可逆的钙激活钾(maxi-K)通道激活剂。
GC60834	Fenamic acid	91-40-7	>98.00%
GC60834	Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.
GC60862	GABAA receptor agent 1	1571-87-5	>98.50%
GC60862	GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.
GC60890	Guvacine	498-96-4	-
GC60890	An inhibitor of GABA uptake
GC60929	Ilaprazole sodium	172152-50-0	>98.50%
GC60929	A gastric proton pump inhibitor
GC60975	Lansoprazole Sulfide D4	1216682-38-0	-
GC60975	LansoprazoleSulfideD4是LansoprazoleSulfide的氘代物。LansoprazoleSulfide是质子泵抑制剂Lansoprazole的活性代谢产物。LansoprazoleSulfide是一种口服活性抗结核药，细胞内的IC50值为0.59µM，肉汤中的IC50值为0.46µM。
GC61046	Methocarbamol D5	1189699-70-4	-
GC61046	An internal standard for the quantification of methocarbamol
GC61066	Minoxidil sulfate	83701-22-8	>99.50%
GC61066	Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.
GC61110	Nav1.1 activator 1	2332897-85-3	>98.00%
GC61110	Nav1.1activator1(compound4)是强有效的、能透过血脑屏障的、Nav1.1激动剂，0.03μM可增加衰减Nav1.1电流的时间常数τ。对Nav1.2、Nav1.5、Nav1.6有显著的选择性。
GC61139	Nothofagin	11023-94-2	-
GC61139	Nothofagin是一种二氢查尔酮，是从如意宝(Aspalathuslinearis)中分离得到的。Nothofagin通过阻断钙(calcium)内流来下调NF-κB的转运。Nothofagin具有抗氧化活性，可改善各种炎症反应，例如脓毒症反应和血管炎症。
GC61141	NSC 15364	4550-72-5	>98.00%
GC61141	NSC15364是一种VDAC1寡聚化和细胞凋亡(apoptosis)抑制剂。
GC61155	Omeprazole sodium	95510-70-6	>98.00%
GC61155	An irreversible inhibitor of the gastric proton pump
GC61175	PF-06305591 dihydrate	2703582-76-5	>99.00%
GC61175	PF-06305591dihydrate是一种有效的、高选择性的电压门控钠通道NaV1.8的阻断剂，其IC50值为15nM。具有良好的临床前体外ADME(吸收、分布、代谢和排泄)和安全性。
GC61186	Picrotoxinin	17617-45-7	>98.00%
GC61186	Picrotoxinin是一种来源于天然植物的苦味毒素，存在于一种名为 Anamirta cocculus 的攀援植物的种子中，是一种氯离子通道阻断剂。Picrotoxinin是一种非竞争性的GABA A 受体拮抗剂，负向调节神经递质γ氨基丁酸（GABA）对GABA A 受体的作用。
GC61248	RO2959 monohydrochloride	2309172-44-7	>99.00%
GC61248	RO2959monohydrochloride是一种有效的选择性CRAC通道抑制剂，IC50为402nM。RO2959monohydrochloride是由Orai1/Stim1通道介导的钙存储进入(SOCE)的有效阻滞剂，IC50为25nM。RO2959monohydrochloride还是人IL-2产生的有效抑制剂，有效阻断T细胞受体触发的基因表达和T细胞功能途径。