Membrane Transporter/Ion Channel(跨膜转运)

Cat.No. 产品名称 Information

GC41613 Valnoctamide

戊诺酰胺,Valmethamide

An anxiolytic that suppresses seizures

GC41557 (S)-3'-amino Blebbistatin

(-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin

A more stable form of (–)-blebbistatin

GC41514 Citreoviridin

黄绿青霉素

A mycotoxin that inhibits the mitochondrial ATPase

GC41484 (S)-3'-hydroxy Blebbistatin

(-)-3'-hydroxy Blebbistatin, meta-hydroxy-Blebbistatin, m-hydroxy-Blebbistatin

A more stable form of (–)-blebbistatin

GC41455 Quinine

奎宁

An antimalarial agent

GC41248 Unoprostone

乌诺前列酮

A PGF_2α analog

GC41181 LY2183240 2'-isomer

5-([1,1'-联苯]-4-基甲基)-N,N-二甲基-2H-四唑-2-甲酰胺

A less potent, 2,5-regioisomer of LY2183240

GC41091 (S)-Lansoprazole

左旋兰索拉唑

A proton pump inhibitor

GC41008 epi-Ivermectin B1a

2-dehydro-4-dihydro Avermectin B1a, epi-dihydro Avermectin B1a, 22,23-dihydro Avermectin B1a

An ivermectin B_1a degradation product

GC40860 AC1903 A TRPC5 inhibitor

GC40841 (±)11(12)-EET methyl ester

(±)11,12EpETrE methyl ester

A stable epoxide with a role in the recovery of depleted Ca²⁺ pools

GC40808 (+)-Menthol

D-薄荷醇,D-Menthol

A monoterpene alcohol with antifungal activity

GC40696 (R)-(+)-Pulegone

胡薄荷酮

A monoterpene with anti-inflammatory activity

GC40635 δ2-Avermectin B1a An ivermectin B_1a degradation product

GC40476 Allethrin

丙烯菊酯

A pyrethroid insecticide

GC40466 (±)11(12)-EET

11,12-EET

A racemic version of a CYP450 metabolite of arachidonic acid

GC40456 17(S)-HETE

17(S)-Hydroxyeicosatetraenoic Acid

A potent inhibitor of proximal tubule ATPase activity

GC40455 17(R)-HETE

17(R)-Hydroxyeicosatetraenoic Acid

An inactive isomer of 17-HETE

GC40454 16(S)-HETE

16(S)-Hydroxyeicosatetraenoic Acid

A potent inhibitor of proximal tubule ATPase activity

GC40453 16(R)-HETE

16(R)-Hydroxyeicosatetraenoic Acid

A potent vasodilator

GC40438 (±)5(6)-EET

(±)-顺式-5,6-环氧-8(Z),11(Z),14(Z)-二十碳三烯酸

A racemic version of a CYP450 metabolite of arachidonic acid

GC40434 (±)16-HETE

(±)16-Hydroxyeicosatetraenoic Acid

A potent inhibitor of proximal tubule ATPase activity

GC40377 20-HEPE An EPA metabolite

GC34912 Levamlodipine besylate

苯磺酸左旋氨氯地平,(S)-Amlodipine besylate; Levoamlodipine besylate

Levamlodipine Besylate is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.

GC34833 TC-I 2014 TC-I2014(compound5)是一种强效的、苯并咪唑类的、TRPM8的拮抗剂，其对犬类、人和大鼠通道的IC50值分别为0.8nM,3.0nM和4.4nM。在疼痛动物模型中具有抗痛觉超敏作用。

GC34828 Tat-NR2B9c TFA

Tat-NR2Bct TFA; NA-1 TFA

Tat-NR2B9c(TFA)是由20个氨基酸组成的多肽，为PSD-95的抑制剂，对PSD-95d2和PSD-95d1的EC50值分别为6.7nM和670nM。Tat-NR2B9c同时可降低NMDA诱导的p38的活化，具有神经保护作用。

GC34753 Radiprodil

RGH-896

An NMDA receptor antagonist

GC34745 PTI-428

PTI-428

PTI-428是一种可增强并稳定囊性纤维化跨膜传导调节因子（CFTR）蛋白功能的特异性调节剂。

GC34665 Metaflumizone

氰氟虫腙; BAS-320I

Metaflumizone是一种缩氨基脲杀虫剂，为有效的钠离子通道(sodiumchannel)阻滞剂。

GC34638 JNJ-61432059 JNJ-61432059是具有口服活性的、选择性的AMPAR的负向调节剂，其对GluA1/γ-8的pIC50值为9.7。在老鼠的海马体中显示出具有时间和剂量依赖性的AMPA受体占用情况，在角膜点燃癫痫动物模型中显示出较强的保护作用。

GC34616 HMR 1556 HMR1556，色氨醇衍生物，是一种IKs阻滞剂，在犬和豚鼠的左心室肌细胞中的IC50值分别为10.5nM、34nM。

GC34574 Endovion

NS3728

Endovion (NS 3728, SCO-101) is a potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).

GC34532 CFTR corrector 2 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

GC34494 Bifenazate

联苯肼酯

An acaricide

GC34492 BI-9627 An NHE1 inhibitor

GC34486 BI 01383298 An NaCT inhibitor

GC19522 Sodium oleate

油酸钠,cis-9-Octadecenoic acid sodium salt, Oleic acid sodium salt

A monounsaturated fatty acid

GC40207 Nifedipine-d6

硝苯地平 D6; BAY-a-1040-d6

An internal standard for the quantification of nifedipine

GC40180 Tetrabenazine-d6

(+)-丁苯那嗪 D6；(+)-丁苯喹嗪 D6；(+)-特苯那嗪 D6；(+)-四苯喹嗪 D6

An internal standard for the quantification of tetrabenazine

GC34362 SSD114 hydrochloride SSD114hydrochloride是一种新型GABAB受体正变构调节剂。

GC34352 NMDAR antagonist 1

2,2,2-三氟-N-(丙-2-炔-1-基)乙酰胺

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.

GC34079 Monepantel (AAD1566)

AAD1566

Monepantel (AAD1566)是一种氨基乙腈衍生物类驱虫药，Monepantel可抑制mTOR/p70S6K信号通路诱导自噬。

GC34064 Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride)

氨氧基乙酸半盐酸盐; Carboxymethoxylamine hemihydrochloride; Aminooxyacetate hemihydrochloride

Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride)是一种苹果酸-天冬氨酸穿梭（MAS）抑制剂和γ-氨基丁酸转氨酶（GABA-T）抑制剂。

GC34049 Aranidipine (MPC1304)

阿雷地平,MPC1304

Aranidipine (MPC1304) (MPC1304) 是一种 Ca2+ 通道拮抗剂，具有强效和持久的抗高血压作用。

GC34041 Caldaret (MCC-135)

MCC-135

Caldaret (MCC-135) 是一种细胞内 Ca2+ 处理调节剂，通过反向模式 Na+/Ca2+ 交换抑制起作用。

GC34027 N-Acetylprocainamide (Acecainide)

N-乙酰普鲁卡因胺; Acecainide; NAPA

N-Acetylprocainamide (Accecainide) 是一种 III 类抗心律失常药，可阻断 K+ 通道。

GC34013 Digitoxin

洋地黄毒苷

Digitoxin是一种天然存在的心脏糖苷类和抗癌剂，主要从Digitalis lanata中提取。Digitoxin能有效抑制1型单纯疱疹病毒（HSV-1）复制，其EC₅₀值为0.05μM，并在48h内对HeLa宫颈癌细胞表现出最高的细胞毒性，IC₅₀为28nM。

GC33895 FR183998 free base

FR183998freebase是一种有效的Na+/H+-exchange抑制剂，通过测量在大鼠淋巴细胞、血小板及人血小板pHi值的变化中，得到IC50值分别为0.3nM，6.5nM和3.1nM。

GC33851 Cloperastine fendizoate

氯苄哌醚联苯酰苯酸盐

Cloperastinefendizoate抑制hERGK+电流，IC50为27nM，这种作用具有浓度依赖性。

GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride)

盐酸利多卡因; Lignocaine hydrochloride

Lidocaine hydrochloride (Lignocaine hydrochloride)是一种氨基酰胺类局部麻醉剂，可抑制voltage-insensitive ‘flicker’ K⁺ channel，IC₅₀值为220μM。