Veratridine

目录号: GC14730纯度: >99.50%同义词: 藜芦定/藜芦碱I,3-Veratroylveracevine

Veratridine (3-Veratroylveracevine) 是一种植物神经毒素，一种电压门控钠通道 (VGSCs) 阻滞剂。

Cas No.: 71-62-5

规格	价格	库存	数量
1mg	¥432.00	现货	1
5mg	¥1,134.00	现货	1
10mg	¥1,796.00	现货	1
25mg	¥3,591.00	现货	1
50mg	¥5,386.00	现货	1
10mM (in 1mL DMSO)	¥1,681.00	现货	1

电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例

Nature
641, 529–536 (2025)
Nature
628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
Cell Research
33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

Voltage-gated Na⁺ channel opener; increases intracellular Ca²⁺ with no effect on the Na⁺/Ca²⁺ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na⁺ permeability and depolarizes excitable tissues.

Reference:
[1]. Purification, solubility and pKa of veratridine.
      McKinney et al.
     Anal.Biochem., 1986;153:33
[2]. Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+      oscillations induced by veratridine.
     Maroto et al.
     Eur.J.Pharmacol., 1994;270:331
[3]. Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation:      implication for epilepsy.
     Fekete et al.
     J.Neurochem., 2009;111:745

实验参考方法 Experimental Reference Method

Cell experiment [1]:
Cell lines	HCT-116 colon cancer cells (expressing GFP-UBXN2A)
Preparation method	The solubility of this compound in DMSO is >10mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	20 and 40 μM, 24 hours
Applications	Veratridine is the main UBXN2A enhancer, increased UBXN2A protein levels in a dose-dependent manner.
Animal experiment [2]:
Animal models	C57Bl/6N mice( HCT-116 cells expressing GFP-UBXN2A were injected into 6 to 8 week old nude　female mice)
Dosage form	Intraperitoneal injection (IP), 0.125 mg/kg for 28 days
Application	Veratridine (VTD) was sufficient to induce UBXN2A protein levels, resulting in colon cancer cell death in UBXN2A- and mot-2-dependent manners.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Abdullah A, Sane S, Branick KA，et al.A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15;6(27):23561-81.

产品文档 Product Documents

批次：Purity:>99.50%

化学性质Chemical Properties

CAS 号

71-62-5

同义词

藜芦定/藜芦碱I,3-Veratroylveracevine

化学名

(3S,4S,4aS,6aS,6bS,8R,8aS,9S,9aS,12S,15aS,15bR,16aR,16bR)-4,6b,8,8a,9,15b-hexahydroxy-9,12,16b-trimethyldocosahydro-1H-4,16a-epoxybenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinolin-3-yl 3,4-dimethoxybenzoate

SMILES

O[C@@]([C@@]1([C@H](CN2[C@H]3CC[C@H](C)C2)[C@]4([C@@]3(C)O)O)O)(C[C@H]4O)[C@H]5[C@@]([C@@](CC[C@@H]6OC(C(C=C7OC)=CC=C7OC)=O)(C)[C@@H]8CC5)(C1)O[C@@]86O

分子式

C₃₆H₅₁NO₁₁

分子量

673.79 g/mol

溶解性

<33.69mg/ml in DMSO

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

质量 (Mass)

体积 (Volume)

浓度 (Concentration)

分子量 (MW)

g/mol