GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GN10114 structure
    GN10114Oroxin A
    CAS: 57396-78-8
    纯度: >98.00%

    A flavonoid glycoside

  • GN10308 structure
    GN10308Chlorogenic acid
    CAS: 327-97-9
    纯度: >98.00%

    Chlorogenic acid是一种有效的神经保护剂，同时具有抗病毒、抗真菌、抗氧化和抗肿瘤作用。Chlorogenic acid还参与调节葡萄糖和脂质代谢，改善胰岛素敏感性。

  • GN10347 structure
    GN10347Nicotinamide (Vitamin B3)
    CAS: 98-92-0
    纯度: >99.50%

    Nicotinamide (Vitamin B3)是维生素B3的酰胺衍生物，可以抑制SIRT1（IC 50 ：50-180μM）和SIRT2（IC 50 ：2μM）的活性。Nicotinamide还可增加细胞中NAD + 、ATP、ROS水平。

  • GN10357 structure
    GN10357Parthenolide
    CAS: 20554-84-1
    纯度: >99.50% / >97.00%

    Parthenolide是一种NF-κB抑制剂，对Eca109、KYSE-510、SiHa和MCF-7细胞48h的IC 50 值分别约为10.3、13.3、8.42和9.54µM。

  • GN10413 structure
    GN10413Agrimol B
    CAS: 55576-66-4
    纯度: >99.50%

    A polyphenol with adipogenesis inhibitory and anticancer activities

  • GN10442 structure
    GN10442Curculigoside
    CAS: 85643-19-2
    纯度: >99.50%

    仙茅苷是 C. 中的主要皂苷。

  • GN10452 structure
    GN10452Paeoniflorin
    CAS: 23180-57-6
    纯度: >98.00%

    Paeoniflorin是一种从毛茛科植物芍药根中提取的蒎烷单萜糖苷，具有多种生物学活性。

  • GN10473 structure
    GN10473Ginkgolide C
    CAS: 15291-76-6
    纯度: >98.00%

    A PAF receptor antagonist

  • GN10518 structure
    GN10518Chitosamine hydrochloride
    CAS: 66-84-2
    纯度: >98.00%

    An amino monosaccharide

  • GN10584 structure
    GN10584Ginsenoside Rk1
    CAS: 494753-69-4
    纯度: >98.00%

    人参皂甙 Rk1 是通过在高温下加工人参植物（主要是 Sung Ginseng，SG）而产生的独特成分 。

  • GN10627 structure
    GN10627Atractylenolide I
    CAS: 73069-13-3
    纯度: >98.00%

    A sesquiterpene with diverse biological activities

  • GN10629 structure
    GN106295,7-dihydroxychromone
    CAS: 31721-94-5
    纯度: >99.00%

    5,7-dihydroxychromone是一种从花生壳中提取的黄酮类分解产物，能抑制曼陀罗、玉米、花生和小麦胚根的伸长。

  • GN10669 structure
    GN10669Glucosamine sulfate
    CAS: 29031-19-4
    纯度: >98.00%

    氨基葡萄糖硫酸盐（D-氨基葡萄糖硫酸盐）是一种氨基糖，是糖基化蛋白质和脂质生化合成的重要前体，用作膳食补充剂。

  • GC10524 structure
    GC10524GSK 525768A
    CAS: 1260530-25-3
    纯度: >99.00%

    GSK 525768A 是 GSK525762A 的非活性对映异构体。 GSK 525768A 对 BET 没有任何活动。

  • GC10690 structure
    GC10690BYK 204165
    CAS: 1104546-89-5
    纯度: >99.50%

    A selective inhibitor of PARP1

  • GC10920 structure
    GC10920BMN-673 8R,9S
    CAS: 1207456-00-5
    纯度: >98.00%

    BMN-673 8R,9S ((8R,9S)-BMN-673) 是 Talazoparib 的对映异构体。 BMN-673 8R,9S 是一种 PARP1 抑制剂，IC50 为 144 nM。

  • GC11674 structure
    GC11674WIKI4
    CAS: 838818-26-1
    纯度: >99.50%

    A potent TNKS1/2 inhibitor

  • GC12390 structure
    GC12390A-966492
    CAS: 934162-61-5
    纯度: >99.00%

    A PARP1 and PARP2 inhibitor

  • GC12680 structure
    GC12680DR 2313
    CAS: 284028-90-6
    纯度: >98.50%

    A PARP inhibitor

  • GC14324 structure
    GC14324TG101348 (SAR302503)
    CAS: 936091-26-8
    纯度: >99.50%

    TG101348 (SAR302503)是一种选择性小分子JAK2抑制剂，IC 50 值为3nM。

  • GC14434 structure
    GC14434BYK 49187
    CAS: 163120-31-8

    Potent PARP-1/PARP-2 inhibitor

  • GC14509 structure
    GC14509UPF 1069
    CAS: 1048371-03-4
    纯度: >99.00% / >98.00%

    A selective PARP2 inhibitors

  • GC15610 structure
    GC15610UNC0638
    CAS: 1255580-76-7
    纯度: >99.00%

    A G9a and GLP histone methyltransferase inhibitor

  • GC17775 structure
    GC17775NU 1025
    CAS: 90417-38-2
    纯度: >98.00%

    An inhibitor of PARP