GlpBio

Bromodomain

Bromodomain(溴域)

Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

Bromodomain 相关产品(45)

  • GC16531 structure
    GC16531Bromodomain Inhibitor, (+)-JQ1
    CAS: 1268524-70-4
    纯度: >99.50%

    A selective inhibitor of BET bromodomains

  • GC10174 structure
    GC10174SGC-CBP30
    CAS: 1613695-14-9
    纯度: >99.50%

    A potent inhibitor of CREBBP/EP300 bromodomains

  • GC10382 structure
    GC10382CPI-637
    CAS: 1884712-47-3
    纯度: >99.50%

    An inhibitor of CBP/EP300 bromodomains

  • GC10727 structure
    GC10727Ischemin sodium salt

    CBP bromodomain inhibitor

  • GC10979 structure
    GC10979PFI 4
    CAS: 900305-37-5
    纯度: >98.00%

    A chemical probe for BRPF1

  • GC12440 structure
    GC12440GSK 5959
    CAS: 901245-65-6
    纯度: >98.00%

    An inhibitor of the BRPF1 bromodomain

  • GC12588 structure
    GC12588I-BRD9
    CAS: 1714146-59-4
    纯度: >99.50%

    A BRD9 bromodomain inhibitor

  • GC13014 structure
    GC13014AZD 5153
    CAS: 1869912-39-9

    AZD 5153是BET/BRD4溴结构域的双价抑制剂，AZD 5153对BRD4的IC₅₀值为5nM，可同时结合BRD4的两个溴结构域，显著影响MYC、E2F和mTOR的转录程序，并抑制NSD3靶基因的表达。

  • GC13025 structure
    GC13025GSK6853
    CAS: 1910124-24-1
    纯度: >99.00%

    A selective chemical probe for the bromodomain of BRPF1

  • GC13187 structure
    GC13187I-BET 151 hydrochloride

    A BRD2, BRD3, and BRD4 inhibitor

  • GC13822 structure
    GC13822(-)-JQ1
    CAS: 1268524-71-5
    纯度: >99.50%

    A selective inhibitor of BET bromodomains

  • GC14168 structure
    GC14168UMB-32
    CAS: 1635437-39-6

    An inhibitor of BRD4, TAF1, and TAF1L bromodomains

  • GC14361 structure
    GC14361PFI 3
    CAS: 1819363-80-8
    纯度: >98.00%

    Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5)

  • GC14655 structure
    GC14655OXF BD 02
    CAS: 1429129-68-9

    OXF BD 02 是 BRD4(1)（BRD4 的第一个溴结构域）的选择性抑制剂，IC50 值为 382 nM。

  • GC15152 structure
    GC15152PF-CBP1
    CAS: 1962928-21-7

    An inhibitor of the CBP and p300 bromodomains

  • GC15175 structure
    GC15175BAZ2-ICR
    CAS: 1665195-94-7
    纯度: >98.50%

    A BAZ2A/B bromodomain inhibitor

  • GC15789 structure
    GC15789GSK2801
    CAS: 1619994-68-1
    纯度: >99.50%

    A probe for BAZ2A/B bromodomains

  • GC16299 structure
    GC16299BET bromodomain inhibitor
    CAS: 1380087-89-7
    纯度: >99.50%

    BET 溴结构域抑制剂是从专利 WO/2015/153871A2 化合物实施例 11 中提取的一种有效的 BET 抑制剂。

  • GC16611 structure
    GC16611GW841819X

    BET bromodomain inhibitor

  • GC16726 structure
    GC16726BI-7273
    CAS: 1883429-21-7
    纯度: >99.50%

    A potent BRD9 bromodomain inhibitor

  • GC16763 structure
    GC16763NI-57
    CAS: 1883548-89-7
    纯度: >99.50%

    A BRPF bromodomain inhibitor

  • GC16817 structure
    GC16817BI-9564
    CAS: 1883429-22-8
    纯度: >99.50%

    A selective BRD9/7 bromodomain inhibitor

  • GC17482 structure
    GC17482OF-1
    CAS: 919973-83-4
    纯度: >98.00%

    A bromodomain probe for BRPF proteins

  • GC18750 structure
    GC18750NEO2734
    CAS: 2081072-29-7
    纯度: >99.50%

    NEO2734 (EP31670) 是一种口服有效的双重 p300/CBP 和 BET 溴结构域选择性抑制剂，对 p300/CBP 和 BET 溴结构域的 IC50 值均 <30 nM。 NEO2734 在 SPOP 突变型和野生型前列腺癌中具有活性。