Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Chromatin/Epigenetics 相关产品(1617)

GC17802 MK-4827
CAS: 1038915-60-4
纯度: >99.50% / >98.00%
MK-4827是具有口服活性的PARP抑制剂，可同时抑制PARP1（IC 50 =3.8nM）和PARP2（IC 50 =2.1nM），MK-4827可抑制PARP酶来阻断DNA修复，诱导癌细胞死亡。
GC11310 CCT129202
CAS: 942947-93-5
纯度: >98.00%
An Aurora kinase inhibitor
GC11334 Romidepsin (FK228, depsipeptide)
CAS: 128517-07-7
纯度: >99.50%
Romidepsin (FK228, depsipeptide)是一种有效且选择性的组蛋白去乙酰化酶（HDAC）抑制剂，抑制HDAC1，HDAC2，HDAC4和HDAC6的IC 50 值分别为36nM，47nM，510nM和1.4μM。
GC11975 CHAPS
CAS: 75621-03-3
纯度: >99.00%
CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。
GC13408 CI994 (Tacedinaline)
CAS: 112522-64-2
纯度: >98.00%
An inhibitor of HDAC1, -2, and -3
GC14243 Resminostat hydrochloride
CAS: 1187075-34-8
纯度: >99.00%
An orally bioavailable HDAC inhibitor
GC14340 Tasquinimod
CAS: 254964-60-8
纯度: >98.00%
Tasquinimod是一种具有口服活性的组蛋白去乙酰化酶4（HDAC4）和S100 钙结合蛋白A9（S100A9）抑制剂。
GC16474 4-HQN
CAS: 491-36-1
纯度: >99.50%
A heterocyclic building block
GC17907 3-Deazaneplanocin A (DZNep) hydrochloride
CAS: 120964-45-6
纯度: >99.50%
3-Deazaneplanocin A (DZNep) hydrochloride 是一种腺苷类似物，是一种竞争性 S-腺苷高半胱氨酸水解酶抑制剂，在无细胞试验中的 Ki 为 50 pM。
GC12019 TCS HDAC6 20b
CAS: 956154-63-5
An HDAC6 inhibitor
GC12208 MLN8054
CAS: 869363-13-3
纯度: >99.00%
An inhibitor of Aurora A kinase
GC12991 EB 47
CAS: 366454-36-6
纯度: >99.50%
A PARP1 and TNKS2 inhibitor
GC13237 LMK 235
CAS: 1418033-25-6
纯度: >99.50%
A selective inhibitor of HDAC4 and HDAC5
GC13826 JAK2 Inhibitor V, Z3
CAS: 195371-52-9
A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK
GC13830 Baricitinib phosphate
CAS: 1187595-84-1
纯度: >99.50%
A JAK1 and JAK2 inhibitor
GC11537 MK-4827 tosylate
CAS: 1038915-73-9
纯度: >99.50%
An orally bioavailable PARP1/2 inhibitor
GC12612 JNJ-7706621
CAS: 443797-96-4
纯度: >99.50%
A dual inhibitor of CDKs and Aurora kinases
GC12756 MK-4827 hydrochloride
CAS: 1038915-64-8
纯度: >99.50%
MK-4827 hydrochloride (MK-4827 hydrochloride) 是一种高效且具有口服生物利用度的 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 和 2.1 nM。 MK-4827 hydrochloride 抑制 DNA 损伤的修复，激活细胞凋亡并显示出抗肿瘤活性。
GC15980 WP1066
CAS: 857064-38-1
纯度: >99.50%
WP1066是一种STAT3（信号转导和转录激活因子3）可逆的竞争性抑制剂，针对STAT3 Tyr705位点磷酸化的抑制IC 50 约为2.5μM，通常用于恶性肿瘤及炎症相关疾病的研究。
GC17052 MK-4827 Racemate
CAS: 1038915-75-1
selective inhibitor of PARP1/PARP2
GC14844 Baricitinib (LY3009104, INCB028050)
CAS: 1187594-09-7
纯度: >99.50%
Baricitinib (LY3009104, INCB028050)是一种高效口服JAK1/JAK2抑制剂，对JAK1和JAK2的IC 50 值分别为5.9nM和5.7nM。
GC15217 Danusertib (PHA-739358)
CAS: 827318-97-8
纯度: >98.50%
A pan-Aurora kinase and Abl inhibitor
GC18008 PCI-34051
CAS: 950762-95-5
纯度: >99.00%
PCI-34051是一种高效且选择性的HDAC8抑制剂，其IC 50 为10nM。
GC16008 CUDC-101
CAS: 1012054-59-9
纯度: >99.00%
A multi-target inhibitor of HDACs, EGFR, and HER2

分类产品列表
货号	产品名称	CAS号	纯度
GC17802	MK-4827	1038915-60-4	>99.50% / >98.00%
GC17802	MK-4827是具有口服活性的PARP抑制剂，可同时抑制PARP1（IC 50 =3.8nM）和PARP2（IC 50 =2.1nM），MK-4827可抑制PARP酶来阻断DNA修复，诱导癌细胞死亡。
GC11310	CCT129202	942947-93-5	>98.00%
GC11310	An Aurora kinase inhibitor
GC11334	Romidepsin (FK228, depsipeptide)	128517-07-7	>99.50%
GC11334	Romidepsin (FK228, depsipeptide)是一种有效且选择性的组蛋白去乙酰化酶（HDAC）抑制剂，抑制HDAC1，HDAC2，HDAC4和HDAC6的IC 50 值分别为36nM，47nM，510nM和1.4μM。
GC11975	CHAPS	75621-03-3	>99.00%
GC11975	CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。
GC13408	CI994 (Tacedinaline)	112522-64-2	>98.00%
GC13408	An inhibitor of HDAC1, -2, and -3
GC14243	Resminostat hydrochloride	1187075-34-8	>99.00%
GC14243	An orally bioavailable HDAC inhibitor
GC14340	Tasquinimod	254964-60-8	>98.00%
GC14340	Tasquinimod是一种具有口服活性的组蛋白去乙酰化酶4（HDAC4）和S100 钙结合蛋白A9（S100A9）抑制剂。
GC16474	4-HQN	491-36-1	>99.50%
GC16474	A heterocyclic building block
GC17907	3-Deazaneplanocin A (DZNep) hydrochloride	120964-45-6	>99.50%
GC17907	3-Deazaneplanocin A (DZNep) hydrochloride 是一种腺苷类似物，是一种竞争性 S-腺苷高半胱氨酸水解酶抑制剂，在无细胞试验中的 Ki 为 50 pM。
GC12019	TCS HDAC6 20b	956154-63-5	-
GC12019	An HDAC6 inhibitor
GC12208	MLN8054	869363-13-3	>99.00%
GC12208	An inhibitor of Aurora A kinase
GC12991	EB 47	366454-36-6	>99.50%
GC12991	A PARP1 and TNKS2 inhibitor
GC13237	LMK 235	1418033-25-6	>99.50%
GC13237	A selective inhibitor of HDAC4 and HDAC5
GC13826	JAK2 Inhibitor V, Z3	195371-52-9	-
GC13826	A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK
GC13830	Baricitinib phosphate	1187595-84-1	>99.50%
GC13830	A JAK1 and JAK2 inhibitor
GC11537	MK-4827 tosylate	1038915-73-9	>99.50%
GC11537	An orally bioavailable PARP1/2 inhibitor
GC12612	JNJ-7706621	443797-96-4	>99.50%
GC12612	A dual inhibitor of CDKs and Aurora kinases
GC12756	MK-4827 hydrochloride	1038915-64-8	>99.50%
GC12756	MK-4827 hydrochloride (MK-4827 hydrochloride) 是一种高效且具有口服生物利用度的 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 和 2.1 nM。 MK-4827 hydrochloride 抑制 DNA 损伤的修复，激活细胞凋亡并显示出抗肿瘤活性。
GC15980	WP1066	857064-38-1	>99.50%
GC15980	WP1066是一种STAT3（信号转导和转录激活因子3）可逆的竞争性抑制剂，针对STAT3 Tyr705位点磷酸化的抑制IC 50 约为2.5μM，通常用于恶性肿瘤及炎症相关疾病的研究。
GC17052	MK-4827 Racemate	1038915-75-1	-
GC17052	selective inhibitor of PARP1/PARP2
GC14844	Baricitinib (LY3009104, INCB028050)	1187594-09-7	>99.50%
GC14844	Baricitinib (LY3009104, INCB028050)是一种高效口服JAK1/JAK2抑制剂，对JAK1和JAK2的IC 50 值分别为5.9nM和5.7nM。
GC15217	Danusertib (PHA-739358)	827318-97-8	>98.50%
GC15217	A pan-Aurora kinase and Abl inhibitor
GC18008	PCI-34051	950762-95-5	>99.00%
GC18008	PCI-34051是一种高效且选择性的HDAC8抑制剂，其IC 50 为10nM。
GC16008	CUDC-101	1012054-59-9	>99.00%
GC16008	A multi-target inhibitor of HDACs, EGFR, and HER2