Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Chromatin/Epigenetics 相关产品(1617)

GC11095 Pyroxamide
CAS: 382180-17-8
纯度: >99.50%
A HDAC inhibitor
GC13591 TC-H 106
CAS: 937039-45-7
纯度: >98.00%
A tight-binding inhibitor of class I HDACs
GC10676 AK-7
CAS: 420831-40-9
纯度: >99.50%
An inhibitor of SIRT2
GC11375 UNC1999
CAS: 1431612-23-5
纯度: >99.50%
UNC1999是一种口服活性的EZH2（IC 50 =2nM）和EZH1（IC 50 =45nM）抑制剂。
GC11424 Valproic acid
CAS: 99-66-1
纯度: >98.00%
A class I HDAC inhibitor
GC12667 4SC-202
CAS: 1186222-89-8
纯度: >99.50%
An HDAC1-3 and KDM1A inhibitor
GC13764 Nexturastat A
CAS: 1403783-31-2
纯度: >98.00%
A potent, cell-permeable HDAC6 inhibitor
GC13926 BMS-345541(free base)
CAS: 445430-58-0
纯度: >99.50%
BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。
GC14652 MM-102
CAS: 1417329-24-8
纯度: >98.00%
MM-102是一种高亲和性、细胞通透性的肽模拟物，作为MLL1-WDR5蛋白相互作用的有效抑制剂，IC₅₀为2.4nM，K i <1nM。

分类产品列表
货号	产品名称	CAS号	纯度
GC11095	Pyroxamide	382180-17-8	>99.50%
GC11095	A HDAC inhibitor
GC13591	TC-H 106	937039-45-7	>98.00%
GC13591	A tight-binding inhibitor of class I HDACs
GC10676	AK-7	420831-40-9	>99.50%
GC10676	An inhibitor of SIRT2
GC11375	UNC1999	1431612-23-5	>99.50%
GC11375	UNC1999是一种口服活性的EZH2（IC 50 =2nM）和EZH1（IC 50 =45nM）抑制剂。
GC11424	Valproic acid	99-66-1	>98.00%
GC11424	A class I HDAC inhibitor
GC12667	4SC-202	1186222-89-8	>99.50%
GC12667	An HDAC1-3 and KDM1A inhibitor
GC13764	Nexturastat A	1403783-31-2	>98.00%
GC13764	A potent, cell-permeable HDAC6 inhibitor
GC13926	BMS-345541(free base)	445430-58-0	>99.50%
GC13926	BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。
GC14652	MM-102	1417329-24-8	>98.00%
GC14652	MM-102是一种高亲和性、细胞通透性的肽模拟物，作为MLL1-WDR5蛋白相互作用的有效抑制剂，IC₅₀为2.4nM，K i <1nM。