GlpBio

Protein Ser/Thr Phosphatases

Protein Ser/Thr Phosphatases(蛋白质丝氨酸/苏氨酸磷酸酶)

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Protein Ser/Thr Phosphatases 相关产品(31)

  • GC10169 structure
    GC10169NSC 87877
    CAS: 56990-57-9
    纯度: >98.00%

    A potent inhibitor of SHP-1 and SHP-2

  • GC12604 structure
    GC12604Fumonisin B1
    CAS: 116355-83-0
    纯度: >98.00% / >95.00%

    A mycotoxin

  • GC12743 structure
    GC12743Calcineurin Autoinhibitory Peptide
    CAS: 148067-21-4

    Calcineurin autoinhibitory peptide 是 Ca2+/calmodulin-dependent protein phosphatase (calcineurin) 的选择性抑制剂，IC50 为 ~10 μM。

  • GC14024 structure
    GC14024DL-AP3
    CAS: 5652-28-8
    纯度: >95.00%

    A metabotropic glutamate receptor antagonist

  • GC14321 structure
    GC14321Sal 003
    CAS: 1164470-53-4
    纯度: >99.50%

    An inhibitor of eIF2α dephosphorylation

  • GC14395 structure
    GC14395Fostriecin sodium salt
    CAS: 87860-39-7
    纯度: >95.00%

    A potent inhibitor of protein phosphatases 2A and 4

  • GC15718 structure
    GC15718CID 2011756
    CAS: 638156-11-3

    An inhibitor of protein kinase D

  • GC16117 structure
    GC16117INCA-6
    CAS: 3519-82-2
    纯度: >99.00%

    A cell-permeant inhibitor of NFAT signaling

  • GC16256 structure
    GC16256BVT 948
    CAS: 39674-97-0
    纯度: >98.50%

    An inhibitor of protein tyrosine phosphatases

  • GC16958 structure
    GC16958Okadaic acid
    CAS: 78111-17-8
    纯度: >95.00%

    A potent inhibitor of protein phosphatases

  • GC17011 structure
    GC17011C2 Ceramide
    CAS: 3102-57-6
    纯度: >98.00%

    C2 Ceramide是一种短链细胞渗透性神经酰胺类似物，可抑制Bcl2蛋白的磷酸化，IC 50 值为14μmol/L。

  • GC17344 structure
    GC17344Alexidine dihydrochloride
    CAS: 1715-30-6
    纯度: >99.00%

    An alkyl bis(biguanide) antiseptic

  • GC17676 structure
    GC17676Nafamostat
    CAS: 81525-10-2

    Nafamostat是一种合成的丝氨酸蛋白酶抑制剂。

  • GC17966 structure
    GC17966NFAT Inhibitor
    CAS: 249537-73-3
    纯度: >98.50%

    NFAT inhibitor是活化T细胞核因子（NFAT）的细胞渗透性肽抑制剂，选择性抑制钙调磷酸酶介导的NFAT的去磷酸化。

  • GC18106 structure
    GC18106Calyculin A
    CAS: 101932-71-2
    纯度: >99.00% / >98.00% / >95.00%

    Calyculin A是蛋白磷酸酶1（PP1）和蛋白磷酸酶2A（PP2A）的强效抑制剂, IC 50 值分别为2nM和0.5–1.0nM。

  • GC11381 structure
    GC11381Tautomycetin
    CAS: 119757-73-2
    纯度: >98.00%

    Tautomycetin 是一种有效的特异性 PP1 抑制剂，具有潜在的细胞凋亡诱导活性。

  • GC11561 structure
    GC11561NSC 95397
    CAS: 93718-83-3
    纯度: >98.00%

    An irreversible inhibitor of Cdc25 isoforms

  • GC11806 structure
    GC11806β-Glycerophosphate (sodium salt hydrate)
    CAS: 13408-09-8
    纯度: >98.00%

    An inhibitor of alkaline phosphatase

  • GC12020 structure
    GC12020TCS 401
    CAS: 243966-09-8
    纯度: >98.00%

    A selective PTP1B inhibitor

  • GC12082 structure
    GC12082Cantharidic Acid (sodium salt)
    CAS: 1465-77-6

    A protein phosphatase inhibitor

  • GC12189 structure
    GC12189LB-100
    CAS: 1026680-07-8

    A PP2A inhibitor with anticancer activity

  • GC12498 structure
    GC12498Sephin1
    CAS: 13098-73-2
    纯度: >99.50%

    A selective inhibitor of the phosphatase regulatory subunit PPP1R15A

  • GC12891 structure
    GC12891CCT007093
    CAS: 176957-55-4
    纯度: >98.00%

    An inhibitor of PPM1D

  • GC13442 structure
    GC13442Sanguinarine chloride
    CAS: 5578-73-4
    纯度: >99.00%

    A natural alkaloid with anti-inflammatory and anti-oxidant properties