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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Protein Ser/Thr Phosphatases

Protein Ser/Thr Phosphatases(蛋白质丝氨酸/苏氨酸磷酸酶)

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Products for  Protein Ser/Thr Phosphatases

  1. Cat.No. 产品名称 Information
  2. GC17344 Alexidine dihydrochloride

    己联双辛胍二盐酸盐

     An alkyl bis(biguanide) antiseptic
  3. GC15974 bpV(HOpic) (potassium salt, technical grade)

    Bisperoxovanadium(HOpic)

     A PTEN inhibitor
  4. GC16256 BVT 948

    4-羟基-3,3-二甲基-2H-苯并[G]吲哚-2,5(3H)-二酮

     An inhibitor of protein tyrosine phosphatases
  5. GC17011 C2 Ceramide

    N-乙酰基神经鞘氨醇,C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine

     C2 Ceramide是一种短链细胞渗透性神经酰胺类似物，可抑制Bcl2蛋白的磷酸化，IC50值为14μmol/L。
  6. GC12743 Calcineurin Autoinhibitory Peptide Calcineurin autoinhibitory peptide 是 Ca2+/calmodulin-dependent protein phosphatase (calcineurin) 的选择性抑制剂，IC50 为 ~10 μM。
  7. GC18106 Calyculin A

    蛋白磷酸酯酶抑制剂,(-)-Calyculin A

    Calyculin A是蛋白磷酸酶1（PP1）和蛋白磷酸酶2A（PP2A）的强效抑制剂, IC50值分别为2nM和0.5–1.0nM。
  8. GC12082 Cantharidic Acid (sodium salt) A protein phosphatase inhibitor
  9. GC12891 CCT007093

    (2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮

     An inhibitor of PPM1D
  10. GC15718 CID 2011756 An inhibitor of protein kinase D
  11. GC14024 DL-AP3

    DL-2-氨基-3-磷丙酸

     A metabotropic glutamate receptor antagonist
  12. GC14395 Fostriecin sodium salt

    福司曲星

     A potent inhibitor of protein phosphatases 2A and 4
  13. GC12604 Fumonisin B1

    伏马菌素B1

    A mycotoxin
  14. GC16117 INCA-6

    Triptycene-1,4-quinone

     A cell-permeant inhibitor of NFAT signaling
  15. GC12189 LB-100 A PP2A inhibitor with anticancer activity
  16. GC17676 Nafamostat

    萘莫司他

     Nafamostat Mesylate(FUT-175)是一种合成的丝氨酸蛋白酶抑制剂。
  17. GC16290 Nafamostat hydrochloride

    盐酸萘莫司他

     Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂，是一种抗凝剂。
  18. GC17966 NFAT Inhibitor

    VIVIT peptide

     A peptide inhibitor of NFAT
  19. GC14875 NSC 663284

    DA-3003-1

     Inhibitor of Cdc25 isoforms
  20. GC10169 NSC 87877 A potent inhibitor of SHP-1 and SHP-2
  21. GC11561 NSC 95397

    Cdc25 Inhibitor IV, PTP Inhibitor XXIX

     An irreversible inhibitor of Cdc25 isoforms
  22. GC16958 Okadaic acid

    冈田酸

    A potent inhibitor of protein phosphatases
  23. GC16900 PRL-3 Inhibitor

    BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor

     An inhibitor of PTP4A3
  24. GC15120 PTP Inhibitor I

    2-溴-4'-羟基苯乙酮,α-Bromo-4-hydroxyacetophenone|2-Bromo-4'-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II

     A SHP-1(ΔSH2) and PTP1B inhibitor
  25. GC15804 PTP Inhibitor II

    alpha-溴-4-甲氧基苯乙酮,α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone|4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II

     A SHP-1(ΔSH2) inhibitor
  26. GC15969 PTP Inhibitor IV

    Protein Tyrosine Phosphatase Inhibitor IV

     An active-site directed inhibitor of protein tyrosine phosphatases
  27. GC14321 Sal 003

    (2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺

     An inhibitor of eIF2α dephosphorylation
  28. GC13442 Sanguinarine chloride

    氯化血根碱; Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride

     A natural alkaloid with anti-inflammatory and anti-oxidant properties
  29. GC12498 Sephin1

    (E/Z)-Sephin1; (E/Z)-IFB-088

     A selective inhibitor of the phosphatase regulatory subunit PPP1R15A
  30. GC11381 Tautomycetin

    Tautomycetin 是一种有效的特异性 PP1 抑制剂，具有潜在的细胞凋亡诱导活性。
  31. GC12020 TCS 401 A selective PTP1B inhibitor
  32. GC11806 β-Glycerophosphate (sodium salt hydrate)

    五水β-甘油磷酸钠(二钠五水合物)

    An inhibitor of alkaline phosphatase

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