HIF
HIF(缺氧诱发因素)
Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.
HIF 相关产品(101)
- GC13139FG-4592 (ASP1517)CAS: 808118-40-3纯度: >99.50%
FG-4592 作为一种口服生物可利用的缺氧诱导因子 (HIF) 脯氨酰羟化酶抑制剂，可通过 HIF 介导的转录促进协调性红细胞生成。
- GC150842-Methoxyestradiol (2-MeOE2)CAS: 362-07-2纯度: >99.50% / >98.00%
2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。
- GC14282AKBA (3-acetyl-11-keto-β-Boswellic Acid)CAS: 67416-61-9纯度: >98.00%
AKBA (3-acetyl-11-keto-β-Boswellic Acid)是一种五环三萜酸，能够有效地非竞争性地抑制5-脂氧合酶（5-lipoxygenase, 5-LOX），具有抗炎、抗肿瘤、神经保护等多种生物活性。
- GC30263Glucosamine (D-Glucosamine)CAS: 3416-24-8纯度: >98.00%
Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
- GC31230Dencichin (Dencichine)CAS: 5302-45-4纯度: >98.00%
Dencichin是一种最初从三七中提取的非蛋白质氨基酸，可以抑制HIF-脯氨酰羟化酶2（PHD-2）的活性。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC12698 | BAY 87-2243 | 1227158-85-1 | >99.50% | |
BAY 87-2243是一种具有高效选择性的缺氧诱导因子-1（HIF-1）抑制剂。 | ||||
| GC13018 | IOX2(Glycine) | 931398-72-0 | >99.50% | |
A selective PHD2 inhibitor | ||||
| GC13139 | FG-4592 (ASP1517) | 808118-40-3 | >99.50% | |
FG-4592 作为一种口服生物可利用的缺氧诱导因子 (HIF) 脯氨酰羟化酶抑制剂，可通过 HIF 介导的转录促进协调性红细胞生成。 | ||||
| GC13141 | KC7F2 | 927822-86-4 | >99.00% / >98.00% | |
KC7F2是转录因子HIF-1（缺氧诱导因子-1）的抑制剂，其IC₅₀分别为20μM ，KC7F2常被用于肿瘤发育和血管形成的研究中 | ||||
| GC14319 | ML 228 | 1357171-62-0 | >98.00% | |
A HIF pathway activator | ||||
| GC15084 | 2-Methoxyestradiol (2-MeOE2) | 362-07-2 | >99.50% / >98.00% | |
2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。 | ||||
| GC15594 | PX 12 | 141400-58-0 | >98.00% | |
An irreversible inhibitor of thioredoxin-1 | ||||
| GC17405 | Chetomin | 1403-36-7 | >95.00% | |
Chetomin是一种来源于 Chaetomium 属真菌的天然生物碱，具有显著的抗癌和抗炎作用。 | ||||
| GC10046 | Molidustat (BAY85-3934) | 1154028-82-6 | >99.00% | |
A pan-HIF-PH inhibitor | ||||
| GC11031 | PX-478 2HCl | 685898-44-6 | >98.00% | |
PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。 | ||||
| GC11767 | Hydralazine HCl | 304-20-1 | >99.50% | |
An antihypertensive agent | ||||
| GC12255 | IOX4 | 1154097-71-8 | >99.50% | |
A selective, bioavailable inhibitor of HIF-PH2 | ||||
| GC12821 | Oltipraz | 64224-21-1 | >99.50% | |
A Nrf2 and CAR activator | ||||
| GC14282 | AKBA (3-acetyl-11-keto-β-Boswellic Acid) | 67416-61-9 | >98.00% | |
AKBA (3-acetyl-11-keto-β-Boswellic Acid)是一种五环三萜酸，能够有效地非竞争性地抑制5-脂氧合酶（5-lipoxygenase, 5-LOX），具有抗炎、抗肿瘤、神经保护等多种生物活性。 | ||||
| GC15379 | JNJ-42041935 | 1193383-09-3 | >99.50% | |
A selective inhibitor of HIF-PH enzymes | ||||
| GC16638 | FG2216 | 223387-75-5 | >99.00% | |
An inhibitor of HIF-PH2 | ||||
| GC16647 | Daprodustat(GSK1278863) | 960539-70-2 | >98.00% | |
A HIF-PH1, -2, and -3 inhibitor | ||||
| GC16811 | Vadadustat | 1000025-07-9 | >98.00% | |
An inhibitor of HIF-PH2 and HIF-PH3 | ||||
| GC16973 | DMOG | 89464-63-1 | >98.50% / >98.00% | |
DMOG（二羟基丙氨酸）是 α-酮戊二酸辅助因子的拮抗剂和 HIF-脯氨酸羟化酶的抑制剂，导致 HIF-1α 蛋白在细胞核中的稳定和积累。 | ||||
| GC18236 | Echinomycin | 512-64-1 | >95.00% | |
An inhibitor of HIF-1-mediated gene transcription | ||||
| GC19251 | MK-8617 | 1187990-87-9 | >98.00% | |
A HIF-PH1, -2, and -3 inhibitor | ||||
| GC30263 | Glucosamine (D-Glucosamine) | 3416-24-8 | >98.00% | |
Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites. | ||||
| GC31230 | Dencichin (Dencichine) | 5302-45-4 | >98.00% | |
Dencichin是一种最初从三七中提取的非蛋白质氨基酸，可以抑制HIF-脯氨酰羟化酶2（PHD-2）的活性。 | ||||
| GC31358 | HIF-2α-IN-1 | 1799948-06-3 | >99.50% | |
HIF-2α-IN-1是一种HIF-2α抑制剂,IC50值小于500nM。 | ||||