GlpBio

HIF

HIF(缺氧诱发因素)

Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.

HIF 相关产品(101)

  • GC31498 structure
    GC31498TP0463518
    CAS: 1558021-37-6
    纯度: >98.00%

    A pan HIF-PH inhibitor

  • GC32083 structure
    GC32083Acriflavine
    CAS: 8048-52-0
    纯度: >98.00%

    Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。

  • GC32228 structure
    GC32228Tilorone dihydrochloride
    CAS: 27591-69-1
    纯度: >99.50%

    An interferon-inducing antiviral agent

  • GC32449 structure
    GC32449Desidustat
    CAS: 1616690-16-4
    纯度: >98.00%

    An inhibitor of HIF-PH

  • GC32680 structure
    GC32680PT-2385
    CAS: 1672665-49-4
    纯度: >99.00%

    PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.

  • GC32724 structure
    GC32724LW6 (HIF-1&alpha; inhibitor)
    CAS: 934593-90-5
    纯度: >98.00%

    LW6是一种缺氧诱导因子1(hypoxia inducing factor 1, HIF)抑制剂,通过降解HIF-1α有效抑制HIF-1α的积累,但不影响缺氧时HIF- 1a mRNA水平。

  • GC32876 structure
    GC32876SYP-5
    CAS: 1384268-04-5
    纯度: >99.50%

    A HIF-1 inhibitor

  • GC32945 structure
    GC32945THS-044
    CAS: 62054-67-5

    THS-044结合且稳定化HIF2αPAS-B折叠状态,调节HIF2活性。

  • GC32948 structure
    GC32948IDF-11774
    CAS: 1429054-28-3

    IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.

  • GC33043 structure
    GC33043EL-102
    CAS: 1233948-61-2
    纯度: >99.50%

    EL102是HIF1α的抑制剂，能够抑制微管蛋白聚合和减少它的稳定性。

  • GC33170 structure
    GC33170ENMD-119 (ENMD 1198)
    CAS: 864668-87-1
    纯度: >98.50%

    ENMD-119 (ENMD 1198) (IRC-110160) 是一种口服活性微管去稳定剂，是一种具有抗增殖和抗血管生成活性的 2-甲氧基雌二醇类似物。 ENMD-119 (ENMD 1198) 适用于抑制人类 HCC 细胞中的 HIF-1alpha 和 STAT3，并导致肿瘤生长和血管形成减少。

  • GC33416 structure
    GC33416AFP464
    CAS: 468719-52-0

    AFP464（NSC710464 游离碱基），是一个活跃的 HIF-1α；抑制剂，IC50 为 0.25 μM，也是一种有效的芳烃受体 (AhR) 激活剂。

  • GC33634 structure
    GC33634Enarodustat (JTZ-951)
    CAS: 1262132-81-9
    纯度: >98.00%

    A pan HIF-PH inhibitor

  • GC34595 structure
    GC34595GN44028
    CAS: 1421448-26-1
    纯度: >99.00% / >98.00%

    GN44028是一种缺氧诱导因子（HIF）-1α抑制剂，其IC 50 值为14nM。

  • GC35230 structure
    GC35230Acetylarenobufagin
    CAS: 184673-79-8

    Acetylarenobufagin 是一种类固醇缺氧诱导因子-1 (HIF-I) 调节剂。

  • GC37034 structure
    GC37034PT2977
    CAS: 1672668-24-4
    纯度: >98.00%

    PT2977是一种口服有效的、选择性的HIF-2α抑制剂，其IC 50 为9nM。

  • GC37066 structure
    GC37066Rac-PT2399
    CAS: 1672662-07-5
    纯度: >99.00%

    Rac-PT2399 (Compound 10e) 是 PT2399 的消旋体，是一种有效且特异性的缺氧诱导因子 2a (HIF-2α) 抑制剂，IC50 为 0.01 μM。

  • GC37801 structure
    GC37801TM6089
    CAS: 863421-32-3

    TM6089 是一种独特的 PHD 抑制剂，可刺激 HIF 活性而不会产生铁螯合作用，诱导血管生成并对缺血器官发挥保护作用。 TM6089 局部施用可增强血管生成，并且口服施用在表达缺氧反应的报告载体的转基因大鼠中刺激 HIF 活性。

  • GC37889 structure
    GC37889VCE-004.8
    CAS: 1818428-24-8
    纯度: >98.00%

    VCE-004.8 (VCE-004.8) 是一种具有口服活性的特异性 PPARγ；和 CB2 受体双重激动剂。

  • GC37966 structure
    GC37966ZINC13466751
    CAS: 117953-17-0
    纯度: >98.50%

    ZINC13466751 是一种 HIF-1α/von Hippel-Lindau 相互作用的有效抑制剂，IC50 值为 2.0 ?M。

  • GC38044 structure
    GC38044Fraxinellone
    CAS: 28808-62-0
    纯度: >99.50%

    A liminoid degradant with diverse biological activities

  • GC38767 structure
    GC38767Deoxyshikonin
    CAS: 43043-74-9
    纯度: >99.50%

    Deoxyshikonin是从紫草（ Lithospermum erythrorhizon Sieb ）中分离得到的一种具有抗肿瘤活性的天然产物。

  • GC39146 structure
    GC39146HIF-1 inhibitor-1
    CAS: 2380261-53-8

    An inhibitor of HIF-1 signaling

  • GC40555 structure
    GC40555Tiopronin
    CAS: 1953-02-2
    纯度: >98.00%

    Tiopronin is an antioxidant that has diverse biological activities.