Histone Methyltransferase
Histone Methyltransferase(组蛋白甲基转移酶)
Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).
Histone Methyltransferase 相关产品(238)
- GC131453-Deazaneplanocin,DZNepCAS: 102052-95-9纯度: >98.00%
An inhibitor of lysine methyltransferase EZH2
- GC17334EntacaponeCAS: 130929-57-6纯度: >99.50% / >98.00%
Entacapone是一种有效的、可逆的、外周作用和具有口服活性的儿茶酚-O-甲基转移酶（COMT）抑制剂，可有效抑制大鼠肝脏总COMT，IC 50 和K i 值分别为20.1nM和10.7nM。
- GC10905Amodiaquine dihydrochloride dihydrateCAS: 6398-98-7纯度: >99.50%
A prodrug form of N-desethyl amodiaquine
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC12530 | PFI-2 (hydrochloride) | 1627607-87-7 | >98.00% | |
| GC12932 | EPZ5676 | 1380288-87-8 | >99.50% | |
EPZ5676是一种新型的、高效的、选择性DOT1L组蛋白甲基转移酶抑制剂，K i 值小于80pM，对DOT1L的IC 50 为0.8nM，选择性比作用于其他多种蛋白甲基转移酶高37000倍。 | ||||
| GC13145 | 3-Deazaneplanocin,DZNep | 102052-95-9 | >98.00% | |
An inhibitor of lysine methyltransferase EZH2 | ||||
| GC13878 | EPZ005687 | 1396772-26-1 | >99.00% | |
A potent, selective inhibitor of EZH2 | ||||
| GC17334 | Entacapone | 130929-57-6 | >99.50% / >98.00% | |
Entacapone是一种有效的、可逆的、外周作用和具有口服活性的儿茶酚-O-甲基转移酶（COMT）抑制剂，可有效抑制大鼠肝脏总COMT，IC 50 和K i 值分别为20.1nM和10.7nM。 | ||||
| GP10020 | Histone-H2A-(107-122)-Ac-OH | - | - | |
Histone-H2A peptide | ||||
| GC10021 | CPI-360 | 1802175-06-9 | >99.00% | |
A selective EZH2 inhibitor | ||||
| GC10099 | MS023 | 1831110-54-3 | >98.00% | |
MS023 是 I 型蛋白精氨酸甲基转移酶 (PRMT) 的有效、选择性和细胞活性抑制剂。 | ||||
| GC10259 | BRD4770 | 1374601-40-7 | >99.50% | |
An inhibitor of EHMT2/G9a | ||||
| GC10905 | Amodiaquine dihydrochloride dihydrate | 6398-98-7 | >99.50% | |
A prodrug form of N-desethyl amodiaquine | ||||
| GC11340 | (R)-PFI 2 hydrochloride | 1627607-87-7 | >99.50% | |
A SET7/9 inhibitor | ||||
| GC11414 | GSK503 | 1346572-63-1 | >99.50% | |
A potent, selective EZH2 inhibitor | ||||
| GC12005 | C7280948 | 587850-67-7 | >98.00% | |
A PRMT1 inhibitor | ||||
| GC12171 | BIX 01294 | 935693-62-2 | >99.50% | |
An inhibitor of G9a histone methyltransferase | ||||
| GC12367 | CM-272 | 1846570-31-7 | >98.00% | |
An inhibitor of G9a, GLP, and DNA methyltransferases | ||||
| GC12874 | SGC707 | 1687736-54-4 | >99.00% / >98.00% | |
A potent allosteric inhibitor of PRMT3 | ||||
| GC13634 | (S)-PFI-2 (hydrochloride) | 1627607-88-8 | - | |
Negative control of (R)-PFI 2 | ||||
| GC14062 | EPZ-6438 | 1403254-99-8 | >98.00% / >98.50% / >99.00% | |
EPZ-6438 是一种有效且具有生物利用度的 EZH2 抑制剂，EZH2 是多梳抑制复合物 2 (PRC2) 的催化亚基，可催化组蛋白 H3 (H3K27) 的赖氨酸 27 甲基化，从而抑制含有人 PRC2 的活性抑制常数 K i 值为 2.5 nM 的野生型 EZH2。 | ||||
| GC14240 | MS049 (hydrochloride) | 2095432-59-8 | - | |
A selective, dual PRMT4/PRMT6 inhibitor | ||||
| GC14249 | UNC 0642 | 1481677-78-4 | >99.50% | |
A G9a histone methyltransferase inhibitor | ||||
| GC14585 | GSK591 | 1616391-87-7 | >99.50% | |
A chemical probe for PRMT5 | ||||
| GC14756 | EI1 | 1418308-27-6 | >99.50% | |
A selective inhibitor of EZH2 | ||||
| GC14763 | WDR5 0103 | 890190-22-4 | >98.00% | |
An inhibitor of WDR5 peptide binding | ||||
| GC15102 | EPZ020411 | 1700663-41-7 | >98.00% | |
EPZ020411是一种具有高效选择性，且口服生物利用度高的蛋白质精氨酸甲基转移酶6（PRMT6）抑制剂，IC 50 值为10nM。 | ||||