GlpBio

PARP

PARP(多聚ADP核糖聚合酶)

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

PARP 相关产品(118)

  • GC10145 structure
    GC10145PJ34 hydrochloride
    CAS: 344458-15-7
    纯度: >99.00%

    PJ34 hydrochloride是一种有效且特异性的PARP抑制剂，IC 50 值为110nM。

  • GC12422 structure
    GC12422ABT-888 (Veliparib)
    CAS: 912444-00-9
    纯度: >99.50% / >98.00%

    ABT-888 (Veliparib)是一种有效的PARP1和PARP2抑制剂，Ki分别为5.2和2.9nM。

  • GC12781 structure
    GC12781XAV-939
    CAS: 284028-89-3
    纯度: >98.50% / >98.00%

    XAV-939 选择性抑制 β-连环蛋白介导的转录。

  • GC15353 structure
    GC15353Iniparib (BSI-201)
    CAS: 160003-66-7
    纯度: >99.50%

    A PARP1 inhibitor

  • GC15932 structure
    GC15932BMN 673
    CAS: 1207456-01-6
    纯度: >98.50%

    BMN 673是一种新型且高效的聚ADP核糖聚合酶1和2（PARP1/2）抑制剂，对PARP1的K i 为1.2nM，对PARP2的K i 为0.87nM。

  • GC15955 structure
    GC15955Rucaparib (AG-014699,PF-01367338) phosphate
    CAS: 459868-92-9
    纯度: >99.50%

    Rucaparib (AG-014699,PF-01367338) phosphate是一种口服生物可利用的三环吲哚类聚（ADP-核糖）聚合酶（PARP）抑制剂。

  • GC16318 structure
    GC16318AG-14361
    CAS: 328543-09-5
    纯度: >99.00%

    A PARP1 inhibitor

  • GC17580 structure
    GC17580Olaparib (AZD2281, Ku-0059436)
    CAS: 763113-22-0
    纯度: >99.50% / >98.00%

    Olaparib (AZD2281, Ku-0059436) 是一种有效的选择性 PARP 抑制剂，特异性靶向 PARP1 和 PARP2（IC 50 分别 = 5 nM 和 1 nM）。

  • GC17965 structure
    GC17965AZD2461
    CAS: 1174043-16-3
    纯度: >98.00%

    A PARP inhibitor

  • GC10456 structure
    GC10456Fucosterol
    CAS: 17605-67-3
    纯度: >98.00%

    A natural phytosterol with diverse biological activities

  • GC10995 structure
    GC10995PJ34
    CAS: 344458-19-1
    纯度: >98.00%

    PJ34是一种有效且特异性的PARP抑制剂，IC 50 值为110nM。

  • GC11548 structure
    GC11548Tankyrase Inhibitors (TNKS) 49

    Tankyrase inhibitor

  • GC12496 structure
    GC12496INO-1001
    CAS: 3544-24-9
    纯度: >99.50%

    A PARP inhibitor

  • GC12869 structure
    GC12869JW 55
    CAS: 664993-53-7
    纯度: >99.50%

    A TNKS1/2 inhibitor

  • GC13249 structure
    GC13249Rucaparib (free base)
    CAS: 283173-50-2
    纯度: >99.00%

    Rucaparib (free base)是一种口服生物可利用的三环吲哚类聚（ADP-核糖）聚合酶（PARP）抑制剂。

  • GC13419 structure
    GC13419ME0328
    CAS: 1445251-22-8
    纯度: >99.50%

    A selective PARP3 inhibitor

  • GC13541 structure
    GC13541G007-LK
    CAS: 1380672-07-0
    纯度: >99.00%

    G007-LK是一种有效的、选择性的TNKS1（IC 50 =46nM）和TNKS2（IC 50 =25nM）抑制剂。

  • GC14380 structure
    GC14380BGP-15
    CAS: 66611-37-8
    纯度: >98.00%

    A PARP inhibitor and insulin sensitizer

  • GC15041 structure
    GC15041Tankyrase Inhibitors (TNKS) 22

    Tankyrase inhibitor

  • GC16725 structure
    GC16725AZ6102
    CAS: 1645286-75-4
    纯度: >99.50%

    A TNKS1/2 inhibitor

  • GC16914 structure
    GC16914MN 64
    CAS: 92831-11-3
    纯度: >99.50%

    A TNKS inhibitor

  • GC17555 structure
    GC17555NVP-TNKS656
    CAS: 1419949-20-4
    纯度: >98.00%

    A TNKS2 inhibitor

  • GC18172 structure
    GC18172E7449
    CAS: 1140964-99-3
    纯度: >98.00%

    An inhibitor of PARP1, PARP2, and TNKS1/2

  • GC19264 structure
    GC19264NMS-P118
    CAS: 1262417-51-5
    纯度: >99.50%

    A potent and selective PARP1 inhibitor