• 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

qq在线咨询
Home >> Signaling Pathways >> Chromatin/Epigenetics >> PARP

PARP(多聚ADP核糖聚合酶)

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

Products for  PARP

  1. Cat.No. 产品名称 Information
  2. GC40468 1,5-Isoquinolinediol

    1,5-二羟基异喹啉,NSC 65585

     An inhibitor of poly(ADP-ribose) polymerases
  3. GC62781 2-Methylquinazolin-4-ol

    2-甲基-4(3H)-喹唑酮

     2-Methylquinazolin-4-ol 是一种高效、竞争性的 poly(ADP-ribose) synthetase 抑制剂，其 Ki 值为 1.1 μM。2-Methylquinazolin-4-ol 是哺乳动物天冬氨酸氨基转移酶 (ATCase) 抑制剂，其 IC50 值为 0.20 mM。
  4. GC62805 4’-Methoxychalcone

    4'-甲氧基查尔酮

     4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. 4'-Methoxychalcone significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.
  5. GC16474 4-HQN

    4-羟基喹唑啉

     A heterocyclic building block
  6. GC35150 5,7,4'-Trimethoxyflavone

    5,7,4'-三甲氧基黄酮

     4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
  7. GN10629 5,7-dihydroxychromone

    5,7-二羟基色酮

     A flavone decomposition product with diverse biological activities
  8. GC68161 5-AIQ

    5-Aminoisoquinolin-1-one

     5-AIQ (5-Aminoisoquinolin-1-one) 是一种水溶性的 PARP-1 抑制剂。5-AIQ 是多种药物中的一个重要官能团。5-AIQ 减少肝脏缺血再灌注相关的组织损伤，可用于肝脏缺血再灌注相关治疗条件的研究。
  9. GC45772 6(5H)-Phenanthridinone

    6(5H)-菲啶酮

     An inhibitor of PARP1 and 2
  10. GC12390 A-966492 A PARP1 and PARP2 inhibitor
  11. GC12422 ABT-888 (Veliparib)

    维利帕尼; ABT-888

    ABT-888 (Veliparib) (ABT-888) 是一种有效的 PARP 抑制剂，抑制 PARP1 和 PARP2，Kis 分别为 5.2 和 2.9 nM。
  12. GC16318 AG-14361 A PARP1 inhibitor
  13. GC73642 ALK-IN-26 ALK-IN-26是ALK抑制剂，对ALK酪氨酸激酶的IC50值为7.0 μM。
  14. GC70420 Amelparib Amelparib是PARP-1的强效、口服活性和水溶性抑制剂。
  15. GC70421 Amelparib hydrochloride Amelparib hydrochloride是PARP-1的强效、口服活性和水溶性抑制剂。
  16. GC65899 AZ3391 AZ3391 是一种有效的 PARP 抑制剂。AZ3391 是一种喹喔啉衍生物。PARP 酶家族在许多细胞过程中发挥重要作用，例如复制、重组、染色质重塑和 DNA 损伤修复。AZ3391具有研究中枢神经系统组织中发生的疾病和病症的潜力，例如大脑和脊髓 (信息摘自专利 WO2021260092A1，化合物 23)。
  17. GC16725 AZ6102

    REL-2-[4-[6-[(3R,5S)-3,5-二甲基-1-哌嗪基]-4-甲基-3-吡啶基]苯基]-3,7-二氢-7-甲基-4H-吡咯并[2,3-D]嘧啶-4-酮

     A TNKS1/2 inhibitor
  18. GC46900 AZ9482 A PARP inhibitor
  19. GC73919 AZD-9574-acid PPAR-1抑制剂AZD-9574-acid (70D)可用于合成PROTAC （CAS 2923686-70-6）。
  20. GC17965 AZD2461

    4-[4-氟-3-[(4-甲氧基哌啶-1-基)羰基]苄基]酞嗪-1(2H)-酮

     A PARP inhibitor
  21. GC62310 AZD5305

    AZD5305

     AZD5305 is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal growth inhibitory effects in other cells (IC50s >10μM).
  22. GC73130 Basroparib

    STP1002

     Basroparib是一种具有抗肿瘤活性的强效聚ADP核糖聚合酶（PARP）抑制剂。
  23. GC14380 BGP-15

    (Z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐

     A PARP inhibitor and insulin sensitizer
  24. GC15932 BMN 673

    他拉唑帕利; BMN-673; LT-673

     A PARP inhibitor
  25. GC10920 BMN-673 8R,9S

    他拉唑帕利 (8R,9S); (8R,9S)-BMN-673; (8R,9S)-LT-673

     BMN-673 8R,9S ((8R,9S)-BMN-673) 是 Talazoparib 的对映异构体。 BMN-673 8R,9S 是一种 PARP1 抑制剂，IC50 为 144 nM。
  26. GC35547 BR102375 BR102375 是一种用于治疗 2 型糖尿病的 non-TZD (噻唑烷二酮类) PPAR γ 完全激动剂， 其 EC50 值和 Amax比率值分别为 0.28 μM 和 98%。
  27. GC33223 BRCA1-IN-1 BRCA1-IN-1是一种新型的小分子BRCA1抑制剂，IC50和Ki分别为0.53μM和0.71μM。
  28. GC35550 BRCA1-IN-2 BRCA1-IN-2 (compound 15) 是具有细胞渗透性的 BRCA1 蛋白-蛋白相互作用 (PPI) 的抑制剂，IC50 值 0.31 μM，Kd 值为 0.3 μM， BRCA1-IN-2 通过阻断 BRCA1 (BRCT)2/ 蛋白质相互作用而具有抗肿瘤活性。
  29. GC10690 BYK 204165

    PARP Inhibitor XIV

     A selective inhibitor of PARP1
  30. GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor
  31. GC47055 CAY10749 A dual inhibitor of PARP and PI3K
  32. GC47056 CAY10753 A TNKS2 inhibitor
  33. GC68940 DB008

    DB008 是一种有效的选择性 PARP16 抑制剂，IC50 值为 0.27 μM，含有丙烯酰胺亲电试剂。DB008 具有膜渗透性，可选择性标记 PARP16。
  34. GN10040 Dehydrocorydaline

    脱氢紫堇碱; 13-Methylpalmatine

     Dehydrocorydaline是从延胡索中分离得到的一种季铵生物碱。
  35. GC12680 DR 2313

    3,5,7,8-四氢-2-甲基-4H-硫代吡喃并[4,3-D]嘧啶-4-酮

     A PARP inhibitor
  36. GC64209 E7016

    GPI 21016

     E7016 (GPI 21016) 是一种口服有效的 PARP 抑制剂。E7016 可以通过抑制 DNA 修复来增强肿瘤细胞在体内外的放射敏感性。E7016 用作一种潜在的抗肿瘤剂。
  37. GC18172 E7449

    E7449; 2X-121

     An inhibitor of PARP1, PARP2, and TNKS1/2
  38. GC12991 EB 47 A PARP1 and TNKS2 inhibitor
  39. GC50506 Fluorescein-NAD+

    荧光素-NAD+ 是放射性标记的 NAD 的替代品，也是 ADP 核糖基化的底物。
  40. GC62121 Fluzoparib

    氟唑帕利; SHR3162; Fuzuloparib

     Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity.
  41. GC10456 Fucosterol

    岩皂甾醇,24-ethylidene Cholesterol

     A natural phytosterol with diverse biological activities
  42. GC13541 G007-LK

    Tankyrase 1/2 Inhibitor VI

     A TNKS1/2 inhibitor
  43. GC19542 GeA-69 GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。
  44. GC15353 Iniparib (BSI-201)

    3-硝基-4-碘苯甲酰胺,BSI201,BSI 201

     A PARP1 inhibitor
  45. GC12496 INO-1001

    3-氨基苯甲酰胺,3-aminobenzamide

     A PARP inhibitor
  46. GC12869 JW 55

    Tankyrase 1/2 Inhibitor IV

     A TNKS1/2 inhibitor
  47. GC34195 K-756 K-756是一种直接的选择性tankyrase(TNKS)抑制剂，抑制TNKS1和TNKS2的ADP-核糖基化活性，IC50分别为31和36nM。
  48. GC65907 KSQ-4279

    USP1-IN-1

     KSQ-4279 (USP1-IN-1, Formula I) 是USP1 和 PARP 的抑制剂。
  49. GC47693 m-Methoxybenzamide

    3-甲氧基苯甲酰胺,3-MBA

     A PARP inhibitor
  50. GC13419 ME0328 A selective PARP3 inhibitor
  51. GC62252 Mefuparib hydrochloride

    MPH

     Mefuparib hydrochloride (MPH) 是一种具有口服活性的，底物竞争性和选择性的 PARP1/2 抑制剂，IC50 分别为 3.2 nM 和 1.9 nM。Mefuparib hydrochloride 诱导细胞凋亡 (apoptosis)，并在体内外具有显着的抗癌活性。

Items 1 to 50 of 118 total

per page
  1. 1
  2. 2
  3. 3

Set Descending Direction