GlpBio

PARP

PARP(多聚ADP核糖聚合酶)

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

PARP 相关产品(118)

  • GC73919 structure
    GC73919AZD-9574-acid
    CAS: 2923687-90-3
    纯度: 不显示

    PPAR-1抑制剂AZD-9574-acid (70D)可用于合成PROTAC （CAS 2923686-70-6）。

  • GC73943 structure
    GC73943Polθ/PARP-IN-1
    纯度: >99.00%

    Polθ/PARP-IN-1（化合物25d）是一种有效的双DNA聚合酶θ (Polθ)和PARP抑制剂，IC50值分别为45.6和5.4 nM。

  • GC74078 structure
    GC74078PARP1-IN-29
    CAS: 1567375-93-2
    纯度: 不显示

    PARP1-IN-29是一种口服活性PARP-1抑制剂，IC50值为6.3 nM。

  • GC91435 structure
    GC91435YCH1899
    纯度: >98.00%

    YCH1899是一种聚(ADP-核糖)聚合酶1(PARP1)和PARP2的抑制剂(IC50s = 1)，它选择性地作用于PARP1和PARP2，而不影响PARP3、-4、-5A、-5B、-6、-7、-10和-12 (IC50s = 1 -14.1 nM)。

  • GN10040 structure
    GN10040Dehydrocorydaline
    CAS: 30045-16-0
    纯度: >99.00%

    Dehydrocorydaline是从延胡索中分离得到的一种季铵生物碱。

  • GN10114 structure
    GN10114Oroxin A
    CAS: 57396-78-8
    纯度: >98.00%

    A flavonoid glycoside

  • GN10629 structure
    GN106295,7-dihydroxychromone
    CAS: 31721-94-5
    纯度: >99.00%

    5,7-dihydroxychromone是一种从花生壳中提取的黄酮类分解产物，能抑制曼陀罗、玉米、花生和小麦胚根的伸长。

  • GC10690 structure
    GC10690BYK 204165
    CAS: 1104546-89-5
    纯度: >99.50%

    A selective inhibitor of PARP1

  • GC10920 structure
    GC10920BMN-673 8R,9S
    CAS: 1207456-00-5
    纯度: >98.00%

    BMN-673 8R,9S ((8R,9S)-BMN-673) 是 Talazoparib 的对映异构体。 BMN-673 8R,9S 是一种 PARP1 抑制剂，IC50 为 144 nM。

  • GC11674 structure
    GC11674WIKI4
    CAS: 838818-26-1
    纯度: >99.50%

    A potent TNKS1/2 inhibitor

  • GC12390 structure
    GC12390A-966492
    CAS: 934162-61-5
    纯度: >99.00%

    A PARP1 and PARP2 inhibitor

  • GC12680 structure
    GC12680DR 2313
    CAS: 284028-90-6
    纯度: >98.50%

    A PARP inhibitor

  • GC14434 structure
    GC14434BYK 49187
    CAS: 163120-31-8

    Potent PARP-1/PARP-2 inhibitor

  • GC14509 structure
    GC14509UPF 1069
    CAS: 1048371-03-4
    纯度: >99.00% / >98.00%

    A selective PARP2 inhibitors

  • GC17775 structure
    GC17775NU 1025
    CAS: 90417-38-2
    纯度: >98.00%

    An inhibitor of PARP

  • GC17802 structure
    GC17802MK-4827
    CAS: 1038915-60-4
    纯度: >99.50% / >98.00%

    MK-4827是具有口服活性的PARP抑制剂，可同时抑制PARP1（IC 50 =3.8nM）和PARP2（IC 50 =2.1nM），MK-4827可抑制PARP酶来阻断DNA修复，诱导癌细胞死亡。

  • GC16474 structure
    GC164744-HQN
    CAS: 491-36-1
    纯度: >99.50%

    A heterocyclic building block

  • GC12991 structure
    GC12991EB 47
    CAS: 366454-36-6
    纯度: >99.50%

    A PARP1 and TNKS2 inhibitor

  • GC11537 structure
    GC11537MK-4827 tosylate
    CAS: 1038915-73-9
    纯度: >99.50%

    An orally bioavailable PARP1/2 inhibitor

  • GC12756 structure
    GC12756MK-4827 hydrochloride
    CAS: 1038915-64-8
    纯度: >99.50%

    MK-4827 hydrochloride (MK-4827 hydrochloride) 是一种高效且具有口服生物利用度的 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 和 2.1 nM。 MK-4827 hydrochloride 抑制 DNA 损伤的修复，激活细胞凋亡并显示出抗肿瘤活性。

  • GC17052 structure
    GC17052MK-4827 Racemate
    CAS: 1038915-75-1

    selective inhibitor of PARP1/PARP2

  • GC17783 structure
    GC17783Veliparib dihydrochloride
    CAS: 912445-05-7
    纯度: >99.50%

    An orally bioavailable inhibitor of PARP1 and PARP2