BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor with pIC50 values of 5.38 and 7.35 for PARP-2 and PARP-1 respectively [1].
PARP1 is a nuclear enzyme activated by strand breaks in DNA and involved in the regulation of various cell processes such as DNA repair, apoptosis, organ dysfunction or necrosis [1].
BYK 204165 (PARP inhibitor XIV) is a cell-permeable isoquinolinedione compound that potently and selectively inhibits PARP1. BYK 204165's potency is similar or higher than most current standard PARP-1 inhibitors (just slightly lower than PJ34), and it is 100-fold selective for PARP-1 over PARP-2 [1].
BYK 204165 was not tested in vivo because of BYK its poor water solubility.
References:
[1]. Eltze T, Boer R, Wagner T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol, 2008, 74(6): 1587-98.
BYK 204165
目录号: GC10690纯度: >99.50%同义词: PARP Inhibitor XIV
A selective inhibitor of PARP1
Cas No.: 1104546-89-5
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥360.00 | 现货 | 1 | |
| 5mg | ¥720.00 | 现货 | 1 | |
| 10mg | ¥1,080.00 | 现货 | 1 | |
| 25mg | ¥2,340.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥792.00 | 现货 | 1 |
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产品描述 Description
产品文档 Product Documents
Purity:>99.50%
化学性质Chemical Properties
CAS 号
1104546-89-5
同义词
PARP Inhibitor XIV
化学名
(4E)-4-[(1-methylpyrrol-2-yl)methylidene]isoquinoline-1,3-dione
SMILES
CN1C=CC=C1C=C2C3=CC=CC=C3C(=O)NC2=O
分子式
C15H12N2O2
分子量
252.27 g/mol
溶解性
<25.23mg/ml in DMSO
保存条件
Desiccate at 4°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol