GlpBio

DNA Methyltransferase

DNA Methyltransferase(DNA甲基转移酶)

DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.

DNA Methyltransferase 相关产品(35)

  • GC10946 structure
    GC109465-Azacytidine
    CAS: 320-67-2
    纯度: >98.00%

    5-氮胞苷（也称为 5-AzaC）是一类胞嘧啶类似物的化合物，是一种 DNA 甲基转移酶 (DNMT) 抑制剂，对多发性骨髓瘤 (MM) 细胞（包括 MM.1S）具有强效细胞毒性, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40和Patient-derived MM,半数抑制浓度IC50值分别为1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L , 分别为 3.2 μmol/L 和 1.5 μmol/L . 5-氮胞苷掺入细胞 DNA 和/或 RNA，随后螯合 DNMT 并在 5-氮胞苷的 C6 和半胱氨酸之间形成共价键DNMT 的硫醇盐导致细胞中 DNMT 活性的耗竭和细胞 DNA 的去甲基化 。

  • GC11778 structure
    GC11778Lomeguatrib
    CAS: 192441-08-0
    纯度: >99.50%

    Inactivator of O 6 -methylguanine-DNA methyltransferase

  • GC12153 structure
    GC12153Zebularine
    CAS: 3690-10-6
    纯度: >99.50%

    Zebularine是一种缺失4-氨基基团的胞苷类似物，作为DNA甲基转移酶抑制剂可抑制DNA甲基化。

  • GC13398 structure
    GC13398RG 108
    CAS: 48208-26-0
    纯度: >99.50%

    RG 108是一种强效的DNA甲基转移酶抑制剂，IC 50 值为115nM。

  • GC14366 structure
    GC14366Thioguanine
    CAS: 154-42-7
    纯度: >99.00% / >98.00%

    Thioguanine是一种抗白血病和免疫抑制剂，对重组USP2和冠状病毒PLpro的IC 50 值分别为40μM和25μM。

  • GC14562 structure
    GC14562Nanaomycin A
    CAS: 52934-83-5
    纯度: >98.00%

    A bacterial metabolite

  • GC15255 structure
    GC15255Decitabine(NSC127716, 5AZA-CdR)
    CAS: 2353-33-5
    纯度: >99.50% / >99.00%

    地西他滨(Decitabine, DAC)是一种具有口服生物活性的脱氧胞苷类似物抗代谢物,具有DNA甲基转移酶抑制剂的功能。

  • GC10243 structure
    GC10243Nanaomycin C
    CAS: 58286-55-8

    Amide of nanaomycin A

  • GC11302 structure
    GC11302Hinokitiol
    CAS: 499-44-5
    纯度: >99.50% / >98.00%

    Hinokitiol是一种在 Formosan cypress 中天然存在的tropolone类化合物，具有抗菌和抗癌特性。

  • GC12367 structure
    GC12367CM-272
    CAS: 1846570-31-7
    纯度: >98.00%

    An inhibitor of G9a, GLP, and DNA methyltransferases

  • GC12775 structure
    GC127752',3',5'-triacetyl-5-Azacytidine
    CAS: 10302-78-0

    A prodrug form of 5-azacytidine

  • GC14364 structure
    GC14364SGI-1027
    CAS: 1020149-73-8
    纯度: >99.00%

    A DNA methyltransferase inhibitor

  • GC17428 structure
    GC17428SGI-110
    CAS: 929901-49-5

    SGI-110 (SGI-110) 是第二代 DNA 甲基转移酶 (DNMT) 抑制剂，用于研究急性髓性白血病 (AML) 和骨髓增生异常综合征 (MDS)。

  • GC31365 structure
    GC31365γ-Oryzanol
    CAS: 11042-64-1

    Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).

  • GC32872 structure
    GC32872DC_517
    CAS: 500017-70-9
    纯度: >99.00%

    DC_517是一种DNMT1抑制剂，IC50和Kd值分别为1.7μM和0.91μM。

  • GC33148 structure
    GC33148DC-05
    CAS: 890643-16-0
    纯度: >99.00%

    A non-nucleoside DNMT1 inhibitor

  • GC33320 structure
    GC33320CM-579
    CAS: 1846570-40-8

    CM-579是一线的、可逆的，G9a和DNA甲基转移酶(DNMT)的双抑制剂，其IC50值分别为16nM和32nM。在多种癌细胞中发挥有效活性作用。

  • GC34498 structure
    GC34498Bobcat339 hydrochloride
    CAS: 2436747-44-1
    纯度: >98.00%

    A cytosine derivative

  • GC35180 structure
    GC351806-Methyl-5-azacytidine
    CAS: 105330-94-7

    6-Methyl-5-azacytidine 是一种有效的甲基转移酶抑制剂。

  • GC35714 structure
    GC35714CM-579 trihydrochloride
    纯度: >98.00%

    CM-579 trihydrochloride 是一线的、可逆的，G9a 和DNA 甲基转移酶 (DNMT) 的双抑制剂，其IC50 值分别为 16 nM 和32 nM。在多种癌细胞中发挥有效活性作用。

  • GC36153 structure
    GC36153Glucose-conjugated MGMT inhibitor
    CAS: 382607-78-5

    Glucose-conjugated MGMT inhibitor 是一种有效的 O6-甲基鸟嘌呤-DNA甲基转移酶 (MGMT) 抑制剂，体外（细胞提取物）的 IC50 为 32 nM，在 HeLa S3 细胞中的 IC50 为 10 nM。

  • GC36196 structure
    GC36196Guadecitabine sodium
    CAS: 929904-85-8

    Guadecitabine 是地西他滨和脱氧鸟苷的新型低甲基化二核苷酸，可抵抗胞苷脱氨酶的降解。

  • GC42562 structure
    GC425625-Methyl-2'-deoxycytidine
    CAS: 838-07-3
    纯度: >98.00%

    A pyrimidine nucleoside

  • GC60310 structure
    GC60310Psammaplin A
    CAS: 110659-91-1
    纯度: >96.00%

    PsammaplinA是一种海洋代谢产物，是HDAC和DNA甲基转移酶(DNAmethyltransferases)的有效抑制剂。PsammaplinA是一种高效的选择性HDAC1抑制剂，IC50为0.9nM，对HDAC1的选择性是DAC6的360倍，对HDAC7和HDAC8的效力低1000倍以上。PsammaplinA对革兰氏阳性细菌(Gram-positivebacteria)具有抗菌作用，并抑制DNA合成和DNA促旋酶(DNAgyrase)活性。抗肿瘤活性。