GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC17050 structure
    GC17050CYT387
    CAS: 1056634-68-4
    纯度: >98.50%

    A potent inhibitor of JAK1 and JAK2

  • GC13433 structure
    GC13433AZ 960
    CAS: 905586-69-8
    纯度: >98.00%

    A JAK2 inhibitor

  • GC13558 structure
    GC13558PIM-1 Inhibitor 2
    CAS: 477845-12-8

    A potent PIM-1 kinase inhibitor

  • GC14936 structure
    GC14936Chaetocin
    CAS: 28097-03-2
    纯度: >98.00%

    据报道毛壳素是组蛋白甲基转移酶 (HMT)（例如 SUV39H1）的非特异性抑制剂，从而影响基因表达。

  • GC17836 structure
    GC17836ITF2357 (Givinostat)
    CAS: 732302-99-7
    纯度: >98.00%

    HDAC inhibitor with anti-inflammatory and antineoplastic activities

  • GC10035 structure
    GC10035TG101209
    CAS: 936091-14-4
    纯度: >99.50%

    An inhibitor of JAK2, FLT3, RET, and JAK3

  • GC11572 structure
    GC11572Bardoxolone methyl
    CAS: 218600-53-4
    纯度: >98.50%

    Bardoxolone methyl是核因子红细胞2相关因子2（Nrf2）介导的抗氧化和抗炎反应的有效激活剂，也是NF-κB通路的抑制剂。

  • GC11576 structure
    GC11576Tranylcypromine (2-PCPA) HCl
    CAS: 4548-34-9

    (1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride 是一种有效的抗抑郁剂。

  • GC12548 structure
    GC12548UNC 0631
    CAS: 1320288-19-4
    纯度: >99.00%

    An inhibitor of G9a/GLP methyltransferases

  • GC13103 structure
    GC13103AZ505 ditrifluoroacetate
    CAS: 1035227-44-1
    纯度: >99.50%

    An inhibitor of SMYD2

  • GC13488 structure
    GC13488R8-T198wt
    CAS: 2305815-72-7

    R8-T198wt 是一种细胞可渗透的羧基末端 p27Kip1 肽，通过抑制 Pim-1 激酶表现出抗肿瘤活性。

  • GC13744 structure
    GC13744AZ505
    CAS: 1035227-43-0
    纯度: >99.50%

    An inhibitor of SMYD2

  • GC14490 structure
    GC14490Donepezil HCl
    CAS: 120011-70-3
    纯度: >99.50%

    An AChE inhibitor

  • GC15002 structure
    GC15002Sodium Phenylbutyrate
    CAS: 1716-12-7
    纯度: >99.50%

    Sodium Phenylbutyrate是一种组蛋白去乙酰化酶（HDAC）抑制剂。

  • GC15315 structure
    GC15315Scriptaid
    CAS: 287383-59-9
    纯度: >98.50%

    HDAC inhibitor

  • GC16290 structure
    GC16290Nafamostat hydrochloride
    CAS: 80251-32-7

    Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂，是一种抗凝剂。

  • GC16518 structure
    GC16518UNC 0646
    CAS: 1320288-17-2
    纯度: >99.50%

    An inhibitor of G9a/GLP methyltransferases

  • GC17162 structure
    GC17162MK-5108 (VX-689)
    CAS: 1010085-13-8
    纯度: >98.00%

    MK-5108 (VX-689)是一种有效的ATP竞争性Aurora A激酶抑制剂，IC 50 值为0.064nM。

  • GC17314 structure
    GC17314OG-L002
    CAS: 1357302-64-7
    纯度: >99.50%

    An LSD1 inhibitor

  • GC17783 structure
    GC17783Veliparib dihydrochloride
    CAS: 912445-05-7
    纯度: >99.50%

    An orally bioavailable inhibitor of PARP1 and PARP2

  • GC11491 structure
    GC11491SGC 0946
    CAS: 1561178-17-3
    纯度: >99.50%

    A potent inhibitor of DOT1L

  • GC12083 structure
    GC12083CEP-33779
    CAS: 1257704-57-6
    纯度: >99.00%

    A potent, orally available inhibitor of JAK2

  • GC13383 structure
    GC13383EPZ004777
    CAS: 1338466-77-5
    纯度: >98.00%

    EPZ004777 作为一种有效的表观遗传调节剂，可以逆转 TGF-β1 诱导的 T 调节细胞，可用于治疗多种免疫疾病。

  • GC14151 structure
    GC14151CBB1007
    CAS: 1379573-92-8

    CBB1007 是一种细胞可渗透的脒基胍化合物，可作为一种有效的、可逆的和底物竞争性 LSD1 选择性抑制剂（hLSD1 的 IC50 = 5.27 μM）。