GlpBio

JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

JAK 相关产品(162)

  • GC12454 structure
    GC12454BMS-911543
    CAS: 1271022-90-2

    A potent, selective JAK2 inhibitor

  • GC12504 structure
    GC12504AZD1480
    CAS: 935666-88-9
    纯度: >98.50% / >98.00%

    AZD1480是一种JAK抑制剂（JAK1：IC 50 = 1.3nM；JAK2：IC 50 = 0.4nM） 。

  • GC12579 structure
    GC12579GLPG0634
    CAS: 1206161-97-8
    纯度: >99.50%

    A JAK1 inhibitor

  • GC14191 structure
    GC14191Ruxolitinib (INCB18424)
    CAS: 941678-49-5
    纯度: >98.00%

    Ruxolitinib (INCB18424)作为一种抑制剂，能够抑制Janus相关激酶(JAKs)JAK1和JAK2, IC50 分别为 3.3 nM 和 2.8 nM，Ruxolitinib介导对造血和免疫功能重要的若干细胞因子和生长因子信号。

  • GC14245 structure
    GC14245ZM 39923 HCl
    CAS: 1021868-92-7
    纯度: >99.50%

    A potent inhibitor of JAK3

  • GC15125 structure
    GC15125ZM 449829
    CAS: 4452-06-6

    An inhibitor of JAK3

  • GC15589 structure
    GC15589WHI-P154
    CAS: 211555-04-3
    纯度: >99.00%

    A JAK3 inhibitor

  • GC17033 structure
    GC17033Lestaurtinib
    CAS: 111358-88-4
    纯度: >98.00%

    A potent JAK2 and PRK1 kinase inhibitor

  • GC17586 structure
    GC17586Tofacitinib (CP-690550) Citrate
    CAS: 540737-29-9
    纯度: >99.50%

    A pan-JAK inhibitor

  • GC10341 structure
    GC10341Peficitinb (ASP015K, JNJ-54781532)
    CAS: 944118-01-8
    纯度: >98.00%

    A JAK inhibitor

  • GC10638 structure
    GC10638AT9283
    CAS: 896466-04-9
    纯度: >99.50%

    A broad spectrum kinase inhibitor

  • GC10770 structure
    GC10770Decernotinib(VX-509)
    CAS: 944842-54-0

    A selective JAK3 inhibitor

  • GC11209 structure
    GC11209Cerdulatinib (PRT062070)
    CAS: 1198300-79-6
    纯度: >99.50%

    A dual inhibitor of Syk and JAKs

  • GC11652 structure
    GC11652CHZ868
    CAS: 1895895-38-1
    纯度: >99.00%

    CHZ868 是一种 II 型 JAK2 抑制剂，在 EPOR JAK2 WT Ba/F3 细胞中的 IC50 为 0.17 μM。

  • GC13848 structure
    GC13848LY2784544
    CAS: 1229236-86-5
    纯度: >99.50%

    Potent inhibitor of JAK2

  • GC14676 structure
    GC14676Pacritinib (SB1518)
    CAS: 937272-79-2

    An equipotent inhibitor of FLT3 and JAK2

  • GC14857 structure
    GC14857LFM-A13
    CAS: 244240-24-2
    纯度: >99.50%

    A BTK inhibitor

  • GC14938 structure
    GC14938PF-03394197(Oclacitinib)
    CAS: 1208319-26-9

    A JAK family kinase inhibitor

  • GC16875 structure
    GC16875FLLL32
    CAS: 1226895-15-3
    纯度: >99.50%

    An inhibitor of JAK2/STAT3 signaling

  • GC17222 structure
    GC17222GLPG0634 analogue
    CAS: 1206101-20-3
    纯度: >98.50%

    GLPG0634 类似物 (Compoun 176) 是一种广谱 JAK 抑制剂，对 JAK1、JAK2 和 JAK3 的 IC50 值 <100 nM。

  • GC17762 structure
    GC17762NSC 33994
    CAS: 82058-16-0

    NSC 33994 (G6) 是一种选择性 JAK2 抑制剂，IC50 为 60 nM。

  • GC19204 structure
    GC19204Itacitinib
    CAS: 1334298-90-6
    纯度: >99.50%

    Itacitinib是一种JAK1抑制剂（IC 50 =2nM），Itacitinib可通过选择性抑制JAK1酪氨酸激酶以调节JAK-STAT信号通路，同时通过减少促炎细胞因子的产生以调控免疫反应。

  • GC19288 structure
    GC19288PF-06651600
    CAS: 1792180-81-4
    纯度: >99.50%

    PF-06651600 (PF-06651600) 是一种具有口服活性的选择性 JAK3 抑制剂，IC50 为 33.1 nM。

  • GC19320 structure
    GC19320SAR-20347
    CAS: 1450881-55-6
    纯度: >98.00%

    A JAK family kinase inhibitor