GlpBio

JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

JAK 相关产品(162)

  • GC10035 structure
    GC10035TG101209
    CAS: 936091-14-4
    纯度: >99.50%

    An inhibitor of JAK2, FLT3, RET, and JAK3

  • GC11572 structure
    GC11572Bardoxolone methyl
    CAS: 218600-53-4
    纯度: >98.50%

    Bardoxolone methyl是核因子红细胞2相关因子2（Nrf2）介导的抗氧化和抗炎反应的有效激活剂，也是NF-κB通路的抑制剂。

  • GC12083 structure
    GC12083CEP-33779
    CAS: 1257704-57-6
    纯度: >99.00%

    A potent, orally available inhibitor of JAK2

  • GC16468 structure
    GC16468CYT387 sulfate salt
    CAS: 1056636-06-6
    纯度: >98.00%

    A potent inhibitor of JAK1 and JAK2

  • GC15956 structure
    GC15956WHI-P97
    CAS: 211555-05-4
    纯度: >99.00%

    WHI-P97 是一种有效的选择性 JAK-3 抑制剂。

  • GC11525 structure
    GC11525Pyridone 6
    CAS: 457081-03-7
    纯度: >98.50%

    吡啶酮 6 抑制 Jak3，K(I)=5 nM； Pyridone 6 还抑制 Jak 家族成员 Tyk2 和 Jak2，IC(50)=1 nM 和 Jak1，IC(50)=15 nM。

  • GC13229 structure
    GC13229NVP-BSK805
    CAS: 1092499-93-8

    A potent, selective JAK2 inhibitor

  • GC16124 structure
    GC16124Ruxolitinib phosphate
    CAS: 1092939-17-7
    纯度: >99.50%

    A potent and selective JAK1/JAK2 inhibitor

  • GC16828 structure
    GC16828Tofacitinib (CP-690550,Tasocitinib)
    CAS: 477600-75-2
    纯度: >98.00%

    Tofacitinib (CP-690550,Tasocitinib)是一种Janus激酶（JAK）抑制剂，用于治疗类风湿关节炎、银屑病关节炎、强直性脊柱炎、多关节病程青少年特发性关节炎和溃疡性结肠炎。

  • GC17020 structure
    GC17020S-Ruxolitinib (INCB018424)
    CAS: 941685-37-6
    纯度: >99.50%

    鲁索替尼 S 对映体是鲁索替尼的 S 对映体。鲁索替尼 S 对映异构体是一种 JAK 抑制剂

  • GC14327 structure
    GC14327XL019
    CAS: 945755-56-6
    纯度: >98.00%

    A potent, bioavailable JAK2 inhibitor

  • GC12064 structure
    GC12064SB1317
    CAS: 937270-47-8
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC17055 structure
    GC170551,2,3,4,5,6-Hexabromocyclohexane
    CAS: 1837-91-8

    1,2,3,4,5,6-六溴环己烷（1,2,3,4,5,6-Hexabromocyclohexane）直接抑制JAK2激酶结构域内的口袋，抑制自身磷酸化。

  • GC15391 structure
    GC15391Cercosporamide
    CAS: 131436-22-1

    A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms

  • GC13347 structure
    GC13347Cucurbitacin I
    CAS: 2222-07-3
    纯度: >98.00%

    Cucurbitacin I是一种选择性的Janus激酶（JAK）/STAT3信号通路抑制剂，在A549细胞中的IC 50 值为500nM。

  • GC14671 structure
    GC14671JANEX-1
    CAS: 202475-60-3
    纯度: >98.00%

    A selective JAK3 inhibitor

  • GC12118 structure
    GC12118SD 1008
    CAS: 960201-81-4

    SD 1008 是一种有效的 JAK 抑制剂。 SD 1008 抑制 STAT3、JAK2 和 Src 的酪氨酰磷酸化。 SD 1008 还降低 STAT3 依赖性荧光素酶活性。 SD 1008 通过直接阻断 JAK-STAT3 信号通路增强紫杉醇诱导的卵巢癌细胞凋亡。

  • GC16584 structure
    GC16584TCS 21311
    CAS: 1260181-14-3
    纯度: >95.00%

    A JAK3 inhibitor