GlpBio

JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

JAK 相关产品(162)

  • GC71575 structure
    GC71575Deuruxolitinib
    CAS: 1513883-39-0
    纯度: >99.00%

    Deuruxolitinib氘代Ruxolitinib调节JAK1/JAK2的活性。

  • GC72769 structure
    GC72769(1R)-AZD-1480
    CAS: 935666-99-2
    纯度: >97.00%

    (1R)-AZD-1480是AZD-1480的1R手性异构体，AZD-1480是一种ATP竞争性JAK1和JAK2抑制剂。

  • GC72815 structure
    GC72815Itacnosertib (hydrocholide)
    CAS: 2409543-84-4
    纯度: >99.00%

    Itacnosertib (hydrocholide)是JAK2、ACVR1、ALK2和ALK5的抑制剂。

  • GC73139 structure
    GC73139SJ1008030 formic
    纯度: >97.00%

    SJ1008030 formic是一种选择性降解JAK2的JAK2 PROTAC。

  • GC73148 structure
    GC73148JAK-IN-21
    CAS: 2445499-20-5
    纯度: >99.00%

    JAK-IN-21（例4）是一种选择性和有效的JAK抑制剂，对JAK1、JAK2、J2V617F和TYK2的ic50分别为1.73、2.04、109和62.9 nM。

  • GC73369 structure
    GC73369SJ988497
    CAS: 2595365-41-4
    纯度: >98.00%

    SJ988497是PROTAC JAK2降解剂。

  • GC73456 structure
    GC73456JAK1-IN-11
    CAS: 2427608-43-1
    纯度: >98.00%

    JAK1-IN-11（化合物11）是一种有效的JAK抑制剂，ic50分别为0.02 nM （JAK1）和0.44 nM （JAK2）。

  • GC73475 structure
    GC73475JAK-IN-26
    CAS: 2417134-93-9
    纯度: >98.00%

    JAK-IN-26（化合物2）是一种口服活性JAK抑制剂，具有良好的药代动力学特性。

  • GC73600 structure
    GC73600JAK3-IN-14
    CAS: 454234-24-3
    纯度: >99.00%

    JAK3-IN-14（化合物1）是一种强效的JAK3抑制剂，JAK3和JAK2的IC50值分别为38和600 nM。

  • GC73627 structure
    GC73627HDAC/JAK/BRD4-IN-1
    CAS: 2755325-84-7
    纯度: >95.00%

    HDAC/JAK/BRD4-IN-1（化合物25ap）是一种强效的HDAC/JAK/BRD4三重抑制剂。

  • GC91059 structure
    GC91059LCC-12 (formate)
    纯度: >98.00%

    一种铜（II）螯合剂和二甲双胍衍生物。

  • GC91148 structure
    GC91148JAK Inhibitor 31
    CAS: 2891469-99-9
    纯度: >98.00%

    一种JAK2抑制剂

  • GC91506 structure
    GC91506Bayer 18
    CAS: 1251752-12-1
    纯度: >98.00%

    Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM).

  • GC91689 structure
    GC91689TG46
    CAS: 936091-15-5
    纯度: >98.00%

    TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM).

  • GN10442 structure
    GN10442Curculigoside
    CAS: 85643-19-2
    纯度: >99.50%

    仙茅苷是 C. 中的主要皂苷。

  • GN10584 structure
    GN10584Ginsenoside Rk1
    CAS: 494753-69-4
    纯度: >98.00%

    人参皂甙 Rk1 是通过在高温下加工人参植物（主要是 Sung Ginseng，SG）而产生的独特成分 。

  • GN10627 structure
    GN10627Atractylenolide I
    CAS: 73069-13-3
    纯度: >98.00%

    A sesquiterpene with diverse biological activities

  • GC14324 structure
    GC14324TG101348 (SAR302503)
    CAS: 936091-26-8
    纯度: >99.50%

    TG101348 (SAR302503)是一种选择性小分子JAK2抑制剂，IC 50 值为3nM。

  • GC13826 structure
    GC13826JAK2 Inhibitor V, Z3
    CAS: 195371-52-9

    A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK

  • GC13830 structure
    GC13830Baricitinib phosphate
    CAS: 1187595-84-1
    纯度: >99.50%

    A JAK1 and JAK2 inhibitor

  • GC15980 structure
    GC15980WP1066
    CAS: 857064-38-1
    纯度: >99.50%

    WP1066是一种STAT3（信号转导和转录激活因子3）可逆的竞争性抑制剂，针对STAT3 Tyr705位点磷酸化的抑制IC 50 约为2.5μM，通常用于恶性肿瘤及炎症相关疾病的研究。

  • GC14844 structure
    GC14844Baricitinib (LY3009104, INCB028050)
    CAS: 1187594-09-7
    纯度: >99.50%

    Baricitinib (LY3009104, INCB028050)是一种高效口服JAK1/JAK2抑制剂，对JAK1和JAK2的IC 50 值分别为5.9nM和5.7nM。

  • GC17050 structure
    GC17050CYT387
    CAS: 1056634-68-4
    纯度: >98.50%

    A potent inhibitor of JAK1 and JAK2

  • GC13433 structure
    GC13433AZ 960
    CAS: 905586-69-8
    纯度: >98.00%

    A JAK2 inhibitor