GlpBio

Protein Arginine Deiminase

Protein Arginine Deiminase(精氨酸脱氨酶)

Protein arginine deiminases (PADs) is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. In humans, the PAD family is composed of five, calcium dependent isozymes (PADs 1-4 and 6), which share roughly 50% sequence similarity. PADs are found in a myriad of cell and tissue types, including the epidermis and uterus (PAD1), skeletal muscle, brain, inflammatory cells, several cancer cell lines, and secretory glands (PAD2), hair follicles and keratinocytes (PAD3), granulocytes and several types of cancer (PAD4), and oocytes and embryos (PAD6). PAD4, the best characterized isozyme, has also been shown to citrullinate a number of other proteins, including p300, ING4, RPS2, lamin C, and nucleophosmin.

Protein Arginine Deiminase 相关产品(7)

  • GC63780 structure
    GC63780D-Cl-amidine hydrochloride
    CAS: 2985338-61-0
    纯度: >99.00%

    D-Cl-amidine hydrochloride是有效的、高度选择性的 PAD1 抑制剂。D-Cl-amidine 耐受性好、无明显毒性。

  • GC64367 structure
    GC64367PAD2-IN-1
    CAS: 2095109-82-1

    PAD2-IN-1，一种基于苯并咪唑的衍生物，是一种有效的选择性蛋白精氨酸脱亚氨酶 2 (PAD2) 抑制剂。PAD2-IN-1 对 PAD2 的选择性优于 PAD4 (95 倍) 和 PAD3 (79 倍)。

  • GC66335 structure
    GC66335PAD2-IN-1 hydrochloride
    纯度: >99.00%

    PAD2-IN-1 hydrochloride，一种基于苯并咪唑的衍生物，是一种有效的选择性蛋白精氨酸脱亚氨酶 2 (PAD2) 抑制剂。PAD2-IN-1 hydrochloride 对 PAD2 的选择性优于 PAD4 (95 倍) 和 PAD3 (79 倍)。

  • GC66379 structure
    GC66379AFM-30a hydrochloride
    纯度: >99.00%

    AFM-30a hydrochloride 是一种有效的蛋白质精氨酸脱亚胺酶 2 (PAD2) 抑制剂，具有出色的 PAD2 选择性。AFM-30a hydrochloride 与 PAD2 结合的 EC50 值为 9.5 μM。AFM-30a hydrochloride 还抑制 H3 瓜氨酸化，EC50 值为 0.4 μM。AFM-30a hydrochloride 可用于某些癌症和多种自身免疫性疾病如类风湿性关节炎 (RA)、多发性硬化症、狼疮和溃疡性结肠炎的研究。

  • GC67873 structure
    GC67873PAD-IN-2
    CAS: 2304852-21-7

    PAD-IN-2 是一种有效的 pad4 抑制剂 (IC50: <1 μM)。PAD-IN-2 可用于自身免疫性疾病和癌症的研究，如类风湿性关节炎、血管炎、系统性红斑狼疮、皮肤红斑狼疮、溃疡性结肠炎、囊性纤维化、哮喘、多发性硬化和牛皮癣。

  • GC73447 structure
    GC73447JBI-589
    CAS: 2308504-22-3
    纯度: >98.00%

    JBI-589是一种具有口服生物利用度的非共价PAD4异构体选择性抑制剂。

  • GC73542 structure
    GC73542PAD4-IN-2 TFA
    纯度: >95.00%

    PAD4-IN-2 TFA是一种PAD4抑制剂（IC50=1.94μM）。