GlpBio

HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

HDAC 相关产品(200)

  • GC10322 structure
    GC10322Tubastatin A HCl
    CAS: 1310693-92-5
    纯度: >98.00%

    A potent HDAC6 inhibitor

  • GC11574 structure
    GC11574HPOB
    CAS: 1429651-50-2

    A potent and selective inhibitor of HDAC6

  • GC11625 structure
    GC11625Entinostat (MS-275,SNDX-275)
    CAS: 209783-80-2
    纯度: >99.00% / >98.00%

    Entinostat (MS-275,SNDX-275)是一种强效的、可口服的组蛋白去乙酰化酶（HDACs）抑制剂，对HDAC1和HDAC3的IC₅₀分别为0.368μM和0.501μM，但对HDAC8的抑制作用相对较弱。

  • GC12257 structure
    GC12257Panobinostat (LBH589)
    CAS: 404950-80-7
    纯度: >99.00%

    Panobinostat (LBH589)是一种强效，且具有口服活性和抗肿瘤活性的广谱组蛋白去乙酰化酶（HDAC）抑制剂，IC 50 值为5nM。

  • GC12961 structure
    GC12961Apicidin
    CAS: 183506-66-3
    纯度: >98.00% / >90.00%

    A cell-permeable HDAC inhibitor

  • GC13055 structure
    GC13055Mocetinostat (MGCD0103, MG0103)
    CAS: 726169-73-9
    纯度: >99.00%

    An orally available HDAC inhibitor

  • GC14682 structure
    GC14682PCI-24781 (CRA-024781)
    CAS: 783355-60-2
    纯度: >98.50%

    An HDAC inhibitor

  • GC15114 structure
    GC15114LAQ824 (NVP-LAQ824,Dacinostat)
    CAS: 404951-53-7
    纯度: >98.00%

    LAQ824 (NVP-LAQ824,Dacinostat)是一种新型、高效的组蛋白去乙酰化酶（HDAC）抑制剂，IC 50 为32nM。

  • GC15476 structure
    GC15476JNJ-26481585
    CAS: 875320-29-9
    纯度: >98.00%

    A pan-HDAC inhibitor

  • GC15526 structure
    GC15526Trichostatin A (TSA)
    CAS: 58880-19-6
    纯度: >99.50% / >95.00% / >98.00%

    Trichostatin A (TSA) 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂和抗真菌抗生素，对 HDAC 的 IC50 值为 1.8 nM，具有抑制细胞生长和诱导细胞分化。

  • GC15794 structure
    GC15794Valproic acid sodium salt (Sodium valproate)
    CAS: 1069-66-5
    纯度: >98.00%

    Valproic acid sodium salt (Sodium valproate)（VPA）是一种具有口服活性的组蛋白脱乙酰酶 （HDAC）抑制剂，IC 50 值为1.5mM，抑制HDAC1的IC 50 值为400μM，同时可诱导HDAC2的降解。

  • GC15879 structure
    GC15879Resminostat (RAS2410)
    CAS: 864814-88-0

    Resminostat (RAS2410) (RAS2410; 4SC-201) 是一种有效的 HDAC1、HDAC3 和 HDAC6 抑制剂，平均 IC50 值分别为 42.5、50.1、71.8 nM，对 HDAC8 的活性较低，IC50 为 877 nM .

  • GC15962 structure
    GC15962Belinostat (PXD101)
    CAS: 414864-00-9

    Belinostat (PXD101) 是 HeLa 细胞提取物中组蛋白脱乙酰酶 (HDAC) 活性的新型异羟肟酸型抑制剂，IC50 为 27 nM 。

  • GC16143 structure
    GC16143Varenicline Hydrochloride
    CAS: 230615-23-3
    纯度: >98.50%

    Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。

  • GC16386 structure
    GC16386Tubacin
    CAS: 537049-40-4
    纯度: >95.00%

    Tubacin (tubulin acetylation inducer)是一种选择性抑制组蛋白去乙酰化酶6 (HDAC6)，诱导α-微管蛋白乙酰化的小分子，IC50为0.004µM。

  • GC16456 structure
    GC16456M344
    CAS: 251456-60-7
    纯度: >98.00%

    M344是一种组蛋白去乙酰化酶（HDAC）抑制剂，其IC 50 值为100nM。

  • GC16734 structure
    GC16734Pracinostat (SB939)
    CAS: 929016-96-6
    纯度: >99.50%

    A pan-HDAC inhibitor

  • GC17390 structure
    GC17390Vorinostat (SAHA, MK0683)
    CAS: 149647-78-9
    纯度: >98.00% / >99.00%

    An HDAC inhibitor

  • GA20481 structure
    GA20481Ac-Arg-Gly-Lys(Ac)-AMC
    CAS: 660846-97-9
    纯度: >98.00%

    Ac-Arg-Gly-Lys(Ac)-AMC 是 HDAC 的底物。

  • GA20605 structure
    GA20605Ac-Lys-AMC
    CAS: 156661-42-6
    纯度: >98.00%

    Ac-Lys-AMC（己酰胺），也称为 MAL，是组蛋白去乙酰化酶 HDAC 的荧光底物。

  • GC10417 structure
    GC10417ACY-241
    CAS: 1316215-12-9
    纯度: >98.50%

    An HDAC6 inhibitor

  • GC10423 structure
    GC10423RG2833
    CAS: 1215493-56-3
    纯度: >98.00%

    An HDAC inhibitor

  • GC10839 structure
    GC10839Tubastatin A
    CAS: 1252003-15-8
    纯度: >98.00%

    Tubastatin A 是一种有效的选择性 HDAC6 抑制剂，IC 50 值为 15 nM。并且Tubastatin A也是一种新型GPX4抑制剂，Tubastatin A 直接与 GPX4 结合，诱导乳腺癌细胞铁死亡。

  • GC11249 structure
    GC112492-hexyl-4-Pentynoic Acid
    CAS: 96017-59-3

    An HDAC inhibitor