GlpBio

HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

HDAC 相关产品(200)

  • GC15536 structure
    GC15536NCH 51
    CAS: 848354-66-5
    纯度: >99.50%

    An HDAC inhibitor

  • GC15040 structure
    GC15040NSC 3852
    CAS: 3565-26-2

    A tumor cell differentiating agent

  • GC11095 structure
    GC11095Pyroxamide
    CAS: 382180-17-8
    纯度: >99.50%

    A HDAC inhibitor

  • GC13591 structure
    GC13591TC-H 106
    CAS: 937039-45-7
    纯度: >98.00%

    A tight-binding inhibitor of class I HDACs

  • GC11424 structure
    GC11424Valproic acid
    CAS: 99-66-1
    纯度: >98.00%

    A class I HDAC inhibitor

  • GC12667 structure
    GC126674SC-202
    CAS: 1186222-89-8
    纯度: >99.50%

    An HDAC1-3 and KDM1A inhibitor

  • GC13764 structure
    GC13764Nexturastat A
    CAS: 1403783-31-2
    纯度: >98.00%

    A potent, cell-permeable HDAC6 inhibitor

  • GC13926 structure
    GC13926BMS-345541(free base)
    CAS: 445430-58-0
    纯度: >99.50%

    BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。