HDAC
HDAC(组蛋白去乙酰化酶)
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
HDAC 相关产品(200)
- GC74062LSD1/HDAC6-IN-2CAS: 2982787-50-6纯度: >99.00%
LSD1/HDAC6-IN-2（JBI-802）是一种口服活性LSD1/HDAC6/MOA-A抑制剂，IC50值分别为5 nM、11 nM和5 nM。
- GN10357ParthenolideCAS: 20554-84-1纯度: >99.50% / >97.00%
Parthenolide是一种NF-κB抑制剂，对Eca109、KYSE-510、SiHa和MCF-7细胞48h的IC 50 值分别约为10.3、13.3、8.42和9.54µM。
- GC11334Romidepsin (FK228, depsipeptide)CAS: 128517-07-7纯度: >99.50%
Romidepsin (FK228, depsipeptide)是一种有效且选择性的组蛋白去乙酰化酶（HDAC）抑制剂，抑制HDAC1，HDAC2，HDAC4和HDAC6的IC 50 值分别为36nM，47nM，510nM和1.4μM。
- GC14340TasquinimodCAS: 254964-60-8纯度: >98.00%
Tasquinimod是一种具有口服活性的组蛋白去乙酰化酶4（HDAC4）和S100 钙结合蛋白A9（S100A9）抑制剂。
- GC17836ITF2357 (Givinostat)CAS: 732302-99-7纯度: >98.00%
HDAC inhibitor with anti-inflammatory and antineoplastic activities
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC73828 | F-SAHA | 149648-08-8 | >99.00% | |
F-SAHA是HDAC抑制剂（HDACi），其18F标记的衍生物可用于肿瘤成像研究。 | ||||
| GC73848 | Martinostat hydrochloride | - | >99.00% | |
Martinostat hydrochloride是HDAC的抑制剂，可以用放射性核素标记用于诊断应用。 | ||||
| GC73925 | YSR734 | 3032969-58-4 | >98.00% | |
YSR734（化合物21）是一种共价HDAC抑制剂，对HDAC1、HDAC2和HDAC3的IC50值分别为110 nM、154 nM和143 nM。 | ||||
| GC73933 | CM-1758 | 2256079-39-5 | >98.00% | |
CM-1758是一种组蛋白去乙酰化酶（HDAC）抑制剂。 | ||||
| GC73944 | SE-7552 | 2243575-79-1 | >98.00% | |
SE-7552是一种2-（二氟金属）-1,3,4-恶二唑（DFMO）衍生物，是一种具有口服活性、高选择性、非氨基甲酸酯类HDAC6抑制剂，IC50为33 nM。 | ||||
| GC74007 | SelSA | 1225038-92-5 | >99.00% | |
SelSA是一种选择性的口服活性组蛋白去乙酰化酶6 （HDAC6）抑制剂，IC50为56.9 nM。 | ||||
| GC74062 | LSD1/HDAC6-IN-2 | 2982787-50-6 | >99.00% | |
LSD1/HDAC6-IN-2（JBI-802）是一种口服活性LSD1/HDAC6/MOA-A抑制剂，IC50值分别为5 nM、11 nM和5 nM。 | ||||
| GC91389 | J27644 | - | >95.00% | |
J27644是一种组蛋白去乙酰化酶6（HDAC6）的抑制剂（IC50 = 10 nM）。它选择性地作用于HDAC6，而不影响HDAC1-5（IC50s = 211-516 nM）和HDAC7、8、9和11（IC50s = 137-812 nM）。 | ||||
| GN10357 | Parthenolide | 20554-84-1 | >99.50% / >97.00% | |
Parthenolide是一种NF-κB抑制剂，对Eca109、KYSE-510、SiHa和MCF-7细胞48h的IC 50 值分别约为10.3、13.3、8.42和9.54µM。 | ||||
| GC11334 | Romidepsin (FK228, depsipeptide) | 128517-07-7 | >99.50% | |
Romidepsin (FK228, depsipeptide)是一种有效且选择性的组蛋白去乙酰化酶（HDAC）抑制剂，抑制HDAC1，HDAC2，HDAC4和HDAC6的IC 50 值分别为36nM，47nM，510nM和1.4μM。 | ||||
| GC11975 | CHAPS | 75621-03-3 | >99.00% | |
CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。 | ||||
| GC13408 | CI994 (Tacedinaline) | 112522-64-2 | >98.00% | |
An inhibitor of HDAC1, -2, and -3 | ||||
| GC14243 | Resminostat hydrochloride | 1187075-34-8 | >99.00% | |
An orally bioavailable HDAC inhibitor | ||||
| GC14340 | Tasquinimod | 254964-60-8 | >98.00% | |
Tasquinimod是一种具有口服活性的组蛋白去乙酰化酶4（HDAC4）和S100 钙结合蛋白A9（S100A9）抑制剂。 | ||||
| GC15830 | Daminozide | 1596-84-5 | >98.00% | |
Selective inhibitor of KDM2/7 histone demethylases | ||||
| GC12019 | TCS HDAC6 20b | 956154-63-5 | - | |
An HDAC6 inhibitor | ||||
| GC13237 | LMK 235 | 1418033-25-6 | >99.50% | |
A selective inhibitor of HDAC4 and HDAC5 | ||||
| GC18008 | PCI-34051 | 950762-95-5 | >99.00% | |
PCI-34051是一种高效且选择性的HDAC8抑制剂，其IC 50 为10nM。 | ||||
| GC16008 | CUDC-101 | 1012054-59-9 | >99.00% | |
A multi-target inhibitor of HDACs, EGFR, and HER2 | ||||
| GC17836 | ITF2357 (Givinostat) | 732302-99-7 | >98.00% | |
HDAC inhibitor with anti-inflammatory and antineoplastic activities | ||||
| GC15002 | Sodium Phenylbutyrate | 1716-12-7 | >99.50% | |
Sodium Phenylbutyrate是一种组蛋白去乙酰化酶（HDAC）抑制剂。 | ||||
| GC15315 | Scriptaid | 287383-59-9 | >98.50% | |
HDAC inhibitor | ||||
| GC15965 | MC1568 | 852475-26-4 | - | |
A selective class IIa HDAC inhibitor | ||||
| GC14590 | AR-42 (OSU-HDAC42) | 935881-37-1 | - | |
HDAC inhibitor,novel and potent | ||||