HDAC
HDAC(组蛋白去乙酰化酶)
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
HDAC 相关产品(200)
- GC35551BRD 4354 ditrifluoroacetate
BRD 4354 (ditrifluoroacetate) 是 HDAC5 和 HDAC9 抑制剂，其 IC50 值分别为 0.85，1.88 μM。
- GC35893DomatinostatCAS: 910462-43-0纯度: >98.00%
Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
- GC36690Nampt-IN-3CAS: 2121591-52-2纯度: >99.00%
Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC，IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，最终导致细胞死亡。
- GC36691NanatinostatCAS: 1256448-47-1纯度: >98.00%
Nanatinostat (CHR-3996) 是一种有效的，有口服活性、I 类选择性的组蛋白去乙酰化酶 (HDAC) 抑制剂，IC50 值为 8 nM。
- GC36905PI3K/HDAC-IN-1CAS: 2361418-52-0
PI3K/HDAC-IN-1 是一种有效的 (PI3K/HDAC) 双重抑制剂，高效抑制 PI3Kδ 和 HDAC1 的 IC50 值分别为 8.1 nM 和 1.4 nM。
- GC37753TefinostatCAS: 914382-60-8纯度: >98.00%
Tefinostat (CHR-2845) 是一种单核细胞/巨噬细胞靶向的 HDAC 广谱抑制剂，通过细胞内酯酶人羧酸酯酶-1 (hCE-1) 切割成活性酸 CHR-2847。具有抗抗单核细胞系白血病活性。
- GC37845TucidinostatCAS: 1616493-44-7纯度: >98.00%
Tucidinostat，也称为Chidamide或CS055/HBI-8000，是HDAC1、HDAC2、HDAC3和HDAC10的抑制剂，IC 50 值分别为95 nM、160 nM、67 nM和78 nM。
- GC392141-Naphthohydroxamic acidCAS: 6953-61-3纯度: >98.00%
1-Naphthohydroxamic acid是强效、细胞渗透性和选择性组蛋白脱乙酰酶抑制剂 (HDAC8) 抑制剂（IC?50?= 14 μM）。在体外有抗癌活性。
- GC40094all-trans Retinoic Acid-d5纯度: >99.00%
An internal standard for the quantification of all-trans retinoic acid
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC34629 | J22352 | 2252395-44-9 | >99.50% | |
J22352是一种具有类似靶向嵌合体蛋白水解(PROTAC)特性、高度选择性HDAC6抑制剂，其IC50值为4.7nM，J22352通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进HDAC6降解和诱导抗癌效果，并通过降低PD-L1的免疫抑制活性，使宿主抗肿瘤活性恢复。 | ||||
| GC35551 | BRD 4354 ditrifluoroacetate | - | - | |
BRD 4354 (ditrifluoroacetate) 是 HDAC5 和 HDAC9 抑制剂，其 IC50 值分别为 0.85，1.88 μM。 | ||||
| GC35668 | CG-200745 | 936221-33-9 | - | |
CG-200745 (CG-200745) 是一种具有口服活性的强效 pan-HDAC 抑制剂，其异羟肟酸部分可与催化袋底部的锌结合。 CG-200745 抑制组蛋白 H3 和微管蛋白的去乙酰化。 CG-200745 诱导 p53 的积累，促进 p53 依赖性反式激活，并增强 MDM2 和 p21 (Waf1/Cip1) 蛋白的表达。 CG-200745 增强了吉西他滨耐药细胞对吉西他滨和 5-氟尿嘧啶 (5-FU;) 的敏感性。 CG-200745 诱导细胞凋亡并具有抗肿瘤作用。 | ||||
| GC35893 | Domatinostat | 910462-43-0 | >98.00% | |
Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1. | ||||
| GC36690 | Nampt-IN-3 | 2121591-52-2 | >99.00% | |
Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC，IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，最终导致细胞死亡。 | ||||
| GC36691 | Nanatinostat | 1256448-47-1 | >98.00% | |
Nanatinostat (CHR-3996) 是一种有效的，有口服活性、I 类选择性的组蛋白去乙酰化酶 (HDAC) 抑制剂，IC50 值为 8 nM。 | ||||
| GC36905 | PI3K/HDAC-IN-1 | 2361418-52-0 | - | |
PI3K/HDAC-IN-1 是一种有效的 (PI3K/HDAC) 双重抑制剂，高效抑制 PI3Kδ 和 HDAC1 的 IC50 值分别为 8.1 nM 和 1.4 nM。 | ||||
| GC37643 | SIS17 | 2374313-54-7 | >98.50% | |
SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. | ||||
| GC37753 | Tefinostat | 914382-60-8 | >98.00% | |
Tefinostat (CHR-2845) 是一种单核细胞/巨噬细胞靶向的 HDAC 广谱抑制剂，通过细胞内酯酶人羧酸酯酶-1 (hCE-1) 切割成活性酸 CHR-2847。具有抗抗单核细胞系白血病活性。 | ||||
| GC37845 | Tucidinostat | 1616493-44-7 | >98.00% | |
Tucidinostat，也称为Chidamide或CS055/HBI-8000，是HDAC1、HDAC2、HDAC3和HDAC10的抑制剂，IC 50 值分别为95 nM、160 nM、67 nM和78 nM。 | ||||
| GC38412 | Crotonoside | 1818-71-9 | >98.00% | |
Crotonoside是一种FLT3和HDAC3/6抑制剂，可用于研究急性髓系白血病(AML)。 | ||||
| GC38742 | BRD-6929 | 849234-64-6 | >98.00% | |
An HDAC1 and HDAC2 inhibitor | ||||
| GC39214 | 1-Naphthohydroxamic acid | 6953-61-3 | >98.00% | |
1-Naphthohydroxamic acid是强效、细胞渗透性和选择性组蛋白脱乙酰酶抑制剂 (HDAC8) 抑制剂（IC?50?= 14 μM）。在体外有抗癌活性。 | ||||
| GC39551 | BRD3308 | 1550053-02-5 | >98.00% | |
An HDAC3 inhibitor | ||||
| GC39679 | CG347B | 1598426-03-9 | >98.50% | |
CG347B 是一种选择性的 HDAC6 抑制剂。 | ||||
| GC40094 | all-trans Retinoic Acid-d5 | - | >99.00% | |
An internal standard for the quantification of all-trans retinoic acid | ||||
| GC40674 | APHA Compound 8 | 676599-90-9 | >98.00% | |
A class I and II HDAC inhibitor | ||||
| GC40923 | BRD4884 | 1404559-91-6 | >98.00% | |
A kinetically selective HDAC2 inhibitor | ||||
| GC41085 | HDAC6 Inhibitor | 1259296-46-2 | >99.00% | |
An inhibitor of HDAC6 | ||||
| GC41495 | HDAC3 Inhibitor | 2044701-99-5 | >98.00% | |
An allosteric HDAC3 inhibitor | ||||
| GC43147 | CAY10398 | 193551-00-7 | >98.00% | |
A potent, cost-effective histone deacetylase inhibitor | ||||
| GC43200 | CAY10721 | 848688-62-0 | >98.00% | |
An inhibitor of SIRT3 | ||||
| GC43201 | CAY10722 | 388086-13-3 | >98.00% | |
A SIRT3 inhibitor | ||||
| GC43318 | coumarin-SAHA | 1260635-77-5 | >98.00% | |
A fluorescent probe for HDAC | ||||